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Predictors of Mortality in Early Neonatal Sepsis: A Single-Center Experience

Background and Objectives: Early neonatal sepsis is associated with a significant mortality rate despite modern treatment strategies. Our aim was to identify risk factors contributing to the occurrence of death in newborns with early neonatal sepsis. Materials and Methods: We conducted a retrospecti...

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Autores principales: Jovičić, Marija, Milosavljević, Miloš N., Folić, Marko, Pavlović, Radiša, Janković, Slobodan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057658/
https://www.ncbi.nlm.nih.gov/pubmed/36984605
http://dx.doi.org/10.3390/medicina59030604
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author Jovičić, Marija
Milosavljević, Miloš N.
Folić, Marko
Pavlović, Radiša
Janković, Slobodan M.
author_facet Jovičić, Marija
Milosavljević, Miloš N.
Folić, Marko
Pavlović, Radiša
Janković, Slobodan M.
author_sort Jovičić, Marija
collection PubMed
description Background and Objectives: Early neonatal sepsis is associated with a significant mortality rate despite modern treatment strategies. Our aim was to identify risk factors contributing to the occurrence of death in newborns with early neonatal sepsis. Materials and Methods: We conducted a retrospective cross-sectional study that included newborns with early sepsis who received care in the intensive and semi-intensive care units at the Institute of Neonatology, Belgrade, Serbia. Newborns with early neonatal sepsis who died comprised the case group, whereas those who survived made up the control group. The diagnostic and therapeutic approach to the septic condition was carried out independently of this study, according to valid hospital protocols and current good practice guidelines. The influence of a large number of variables on the examined dichotomous outcome, as well as the mutual interaction of potential predictor variables, was examined by binary logistic regression. Results: The study included 133 pregnant women and 136 newborns with early neonatal sepsis, of which 51 (37.5%) died, while the remaining 85 newborns (62.5%) survived. Newborns who died had a statistically significantly lower birth weight compared to those who survived (882.8 ± 372.2 g vs. 1660.9 ± 721.1 g, p = 0.000). Additionally, compared to newborns who survived, among the deceased neonates there was a significantly higher proportion of extremely preterm newborns (74.5% vs. 22.4%, p = 0.000). The following risk factors for the occurrence of death in early neonatal sepsis were identified: low birth weight, sepsis caused by gram-negative bacteria, and the use of double-inotropic therapy and erythrocyte transfusion during the first week. Conclusions: Pediatricians should pay special attention to infants with early neonatal sepsis in whom any of the identified risk factors are present in order to prevent a fatal outcome.
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spelling pubmed-100576582023-03-30 Predictors of Mortality in Early Neonatal Sepsis: A Single-Center Experience Jovičić, Marija Milosavljević, Miloš N. Folić, Marko Pavlović, Radiša Janković, Slobodan M. Medicina (Kaunas) Article Background and Objectives: Early neonatal sepsis is associated with a significant mortality rate despite modern treatment strategies. Our aim was to identify risk factors contributing to the occurrence of death in newborns with early neonatal sepsis. Materials and Methods: We conducted a retrospective cross-sectional study that included newborns with early sepsis who received care in the intensive and semi-intensive care units at the Institute of Neonatology, Belgrade, Serbia. Newborns with early neonatal sepsis who died comprised the case group, whereas those who survived made up the control group. The diagnostic and therapeutic approach to the septic condition was carried out independently of this study, according to valid hospital protocols and current good practice guidelines. The influence of a large number of variables on the examined dichotomous outcome, as well as the mutual interaction of potential predictor variables, was examined by binary logistic regression. Results: The study included 133 pregnant women and 136 newborns with early neonatal sepsis, of which 51 (37.5%) died, while the remaining 85 newborns (62.5%) survived. Newborns who died had a statistically significantly lower birth weight compared to those who survived (882.8 ± 372.2 g vs. 1660.9 ± 721.1 g, p = 0.000). Additionally, compared to newborns who survived, among the deceased neonates there was a significantly higher proportion of extremely preterm newborns (74.5% vs. 22.4%, p = 0.000). The following risk factors for the occurrence of death in early neonatal sepsis were identified: low birth weight, sepsis caused by gram-negative bacteria, and the use of double-inotropic therapy and erythrocyte transfusion during the first week. Conclusions: Pediatricians should pay special attention to infants with early neonatal sepsis in whom any of the identified risk factors are present in order to prevent a fatal outcome. MDPI 2023-03-18 /pmc/articles/PMC10057658/ /pubmed/36984605 http://dx.doi.org/10.3390/medicina59030604 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jovičić, Marija
Milosavljević, Miloš N.
Folić, Marko
Pavlović, Radiša
Janković, Slobodan M.
Predictors of Mortality in Early Neonatal Sepsis: A Single-Center Experience
title Predictors of Mortality in Early Neonatal Sepsis: A Single-Center Experience
title_full Predictors of Mortality in Early Neonatal Sepsis: A Single-Center Experience
title_fullStr Predictors of Mortality in Early Neonatal Sepsis: A Single-Center Experience
title_full_unstemmed Predictors of Mortality in Early Neonatal Sepsis: A Single-Center Experience
title_short Predictors of Mortality in Early Neonatal Sepsis: A Single-Center Experience
title_sort predictors of mortality in early neonatal sepsis: a single-center experience
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057658/
https://www.ncbi.nlm.nih.gov/pubmed/36984605
http://dx.doi.org/10.3390/medicina59030604
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