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Potential Protective Role of Pregnancy and Breastfeeding in Delaying Onset Symptoms Related to Multiple Sclerosis
The impact of pregnancy and breastfeeding on the development and outcomes of Multiple sclerosis (MS) has been debated for decades. Since several factors can influence the evolution of the disease, the protective role of multiparity and breastfeeding remains uncertain, as well the role of hormone rep...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057678/ https://www.ncbi.nlm.nih.gov/pubmed/36984620 http://dx.doi.org/10.3390/medicina59030619 |
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author | Logoteta, Alessandra Piccioni, Maria Grazia Nistri, Riccardo De Giglio, Laura Bruno, Valentina La Torre, Giuseppe Ianni, Stefano Fabrizi, Luana Muzii, Ludovico Pozzilli, Carlo Ruggieri, Serena |
author_facet | Logoteta, Alessandra Piccioni, Maria Grazia Nistri, Riccardo De Giglio, Laura Bruno, Valentina La Torre, Giuseppe Ianni, Stefano Fabrizi, Luana Muzii, Ludovico Pozzilli, Carlo Ruggieri, Serena |
author_sort | Logoteta, Alessandra |
collection | PubMed |
description | The impact of pregnancy and breastfeeding on the development and outcomes of Multiple sclerosis (MS) has been debated for decades. Since several factors can influence the evolution of the disease, the protective role of multiparity and breastfeeding remains uncertain, as well the role of hormone replacement therapy in the perimenopausal period. We report two cases of relatively late-onset MS in two parous women, who developed their first neurological symptoms after six and nine pregnancies, respectively. Both women breastfed each of their children for 3 to 12 months. One of them underwent surgical menopause and received hormone replacement therapy for 7 years before MS onset. We performed a systematic literature review to highlight the characteristics shared by women who develop the disease in similar conditions, after unique hormonal imbalances, and to collect promising evidence on this controversial issue. Several studies suggest that the beneficial effects of pregnancy and breastfeeding on MS onset and disability accumulation may only be realized when several pregnancies occur. However, these data on pregnancy and breastfeeding and their long-term benefits on MS outcomes suffer from the possibility of reverse causality, as women with milder impairment might choose to become pregnant more readily than those with a higher level of disability. Thus, the hypothesis that multiparity might have a protective role on MS outcomes needs to be tested in larger prospective cohort studies of neo-diagnosed women, evaluating both clinical and radiological features at presentation. |
format | Online Article Text |
id | pubmed-10057678 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100576782023-03-30 Potential Protective Role of Pregnancy and Breastfeeding in Delaying Onset Symptoms Related to Multiple Sclerosis Logoteta, Alessandra Piccioni, Maria Grazia Nistri, Riccardo De Giglio, Laura Bruno, Valentina La Torre, Giuseppe Ianni, Stefano Fabrizi, Luana Muzii, Ludovico Pozzilli, Carlo Ruggieri, Serena Medicina (Kaunas) Review The impact of pregnancy and breastfeeding on the development and outcomes of Multiple sclerosis (MS) has been debated for decades. Since several factors can influence the evolution of the disease, the protective role of multiparity and breastfeeding remains uncertain, as well the role of hormone replacement therapy in the perimenopausal period. We report two cases of relatively late-onset MS in two parous women, who developed their first neurological symptoms after six and nine pregnancies, respectively. Both women breastfed each of their children for 3 to 12 months. One of them underwent surgical menopause and received hormone replacement therapy for 7 years before MS onset. We performed a systematic literature review to highlight the characteristics shared by women who develop the disease in similar conditions, after unique hormonal imbalances, and to collect promising evidence on this controversial issue. Several studies suggest that the beneficial effects of pregnancy and breastfeeding on MS onset and disability accumulation may only be realized when several pregnancies occur. However, these data on pregnancy and breastfeeding and their long-term benefits on MS outcomes suffer from the possibility of reverse causality, as women with milder impairment might choose to become pregnant more readily than those with a higher level of disability. Thus, the hypothesis that multiparity might have a protective role on MS outcomes needs to be tested in larger prospective cohort studies of neo-diagnosed women, evaluating both clinical and radiological features at presentation. MDPI 2023-03-20 /pmc/articles/PMC10057678/ /pubmed/36984620 http://dx.doi.org/10.3390/medicina59030619 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Logoteta, Alessandra Piccioni, Maria Grazia Nistri, Riccardo De Giglio, Laura Bruno, Valentina La Torre, Giuseppe Ianni, Stefano Fabrizi, Luana Muzii, Ludovico Pozzilli, Carlo Ruggieri, Serena Potential Protective Role of Pregnancy and Breastfeeding in Delaying Onset Symptoms Related to Multiple Sclerosis |
title | Potential Protective Role of Pregnancy and Breastfeeding in Delaying Onset Symptoms Related to Multiple Sclerosis |
title_full | Potential Protective Role of Pregnancy and Breastfeeding in Delaying Onset Symptoms Related to Multiple Sclerosis |
title_fullStr | Potential Protective Role of Pregnancy and Breastfeeding in Delaying Onset Symptoms Related to Multiple Sclerosis |
title_full_unstemmed | Potential Protective Role of Pregnancy and Breastfeeding in Delaying Onset Symptoms Related to Multiple Sclerosis |
title_short | Potential Protective Role of Pregnancy and Breastfeeding in Delaying Onset Symptoms Related to Multiple Sclerosis |
title_sort | potential protective role of pregnancy and breastfeeding in delaying onset symptoms related to multiple sclerosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057678/ https://www.ncbi.nlm.nih.gov/pubmed/36984620 http://dx.doi.org/10.3390/medicina59030619 |
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