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Back to the basics: Clinical assessment yields robust mortality prediction and increased feasibility in low resource settings

INTRODUCTION: Mortality prediction aids clinical decision-making and is necessary for trauma quality improvement initiatives. Conventional injury severity scores are often not feasible in low-resource settings. We hypothesize that clinician assessment will be more feasible and have comparable discri...

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Autores principales: Yost, Mark T., Carvalho, Melissa M., Mbuh, Lidwine, Dissak-Delon, Fanny N., Oke, Rasheedat, Guidam, Debora, Nlong, Rene M., Zikirou, Mbengawoh M., Mekolo, David, Banaken, Louis H., Juillard, Catherine, Chichom-Mefire, Alain, Christie, S. Ariane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057736/
https://www.ncbi.nlm.nih.gov/pubmed/36989211
http://dx.doi.org/10.1371/journal.pgph.0001761
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author Yost, Mark T.
Carvalho, Melissa M.
Mbuh, Lidwine
Dissak-Delon, Fanny N.
Oke, Rasheedat
Guidam, Debora
Nlong, Rene M.
Zikirou, Mbengawoh M.
Mekolo, David
Banaken, Louis H.
Juillard, Catherine
Chichom-Mefire, Alain
Christie, S. Ariane
author_facet Yost, Mark T.
Carvalho, Melissa M.
Mbuh, Lidwine
Dissak-Delon, Fanny N.
Oke, Rasheedat
Guidam, Debora
Nlong, Rene M.
Zikirou, Mbengawoh M.
Mekolo, David
Banaken, Louis H.
Juillard, Catherine
Chichom-Mefire, Alain
Christie, S. Ariane
author_sort Yost, Mark T.
collection PubMed
description INTRODUCTION: Mortality prediction aids clinical decision-making and is necessary for trauma quality improvement initiatives. Conventional injury severity scores are often not feasible in low-resource settings. We hypothesize that clinician assessment will be more feasible and have comparable discrimination of mortality compared to conventional scores in low and middle-income countries (LMICs). METHODS: Between 2017 and 2019, injury data were collected from all injured patients as part of a prospective, four-hospital trauma registry in Cameroon. Clinicians used physical exam at presentation to assign a highest estimated abbreviated injury scale (HEAIS) for each patient. Discrimination of hospital mortality was evaluated using receiver operating characteristic curves. Discrimination of HEAIS was compared with conventional scores. Data missingness for each score was reported. RESULTS: Of 9,635 presenting with injuries, there were 206 in-hospital deaths (2.2%). Compared to 97.5% of patients with HEAIS scores, only 33.2% had sufficient data to calculate a Revised Trauma Score (RTS) and 24.8% had data to calculate a Kampala Trauma Score (KTS). Data from 2,328 patients with all scores was used to compare models. Although statistically inferior to the prediction generated by RTS (AUC 0.92–0.98) and KTS (AUC 0.93–0.99), HEAIS provided excellent overall discrimination of mortality (AUC 0.84–0.92). Among 9,269 patients with HEAIS scores was strongly predictive of mortality (AUC 0.93–0.96). CONCLUSION: Clinical assessment of injury severity using HEAIS strongly predicts hospital mortality and far exceeds conventional scores in feasibility. In contexts where traditional scoring systems are not feasible, utilization of HEAIS could facilitate improved data quality and expand access to quality improvement programming.
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spelling pubmed-100577362023-03-30 Back to the basics: Clinical assessment yields robust mortality prediction and increased feasibility in low resource settings Yost, Mark T. Carvalho, Melissa M. Mbuh, Lidwine Dissak-Delon, Fanny N. Oke, Rasheedat Guidam, Debora Nlong, Rene M. Zikirou, Mbengawoh M. Mekolo, David Banaken, Louis H. Juillard, Catherine Chichom-Mefire, Alain Christie, S. Ariane PLOS Glob Public Health Research Article INTRODUCTION: Mortality prediction aids clinical decision-making and is necessary for trauma quality improvement initiatives. Conventional injury severity scores are often not feasible in low-resource settings. We hypothesize that clinician assessment will be more feasible and have comparable discrimination of mortality compared to conventional scores in low and middle-income countries (LMICs). METHODS: Between 2017 and 2019, injury data were collected from all injured patients as part of a prospective, four-hospital trauma registry in Cameroon. Clinicians used physical exam at presentation to assign a highest estimated abbreviated injury scale (HEAIS) for each patient. Discrimination of hospital mortality was evaluated using receiver operating characteristic curves. Discrimination of HEAIS was compared with conventional scores. Data missingness for each score was reported. RESULTS: Of 9,635 presenting with injuries, there were 206 in-hospital deaths (2.2%). Compared to 97.5% of patients with HEAIS scores, only 33.2% had sufficient data to calculate a Revised Trauma Score (RTS) and 24.8% had data to calculate a Kampala Trauma Score (KTS). Data from 2,328 patients with all scores was used to compare models. Although statistically inferior to the prediction generated by RTS (AUC 0.92–0.98) and KTS (AUC 0.93–0.99), HEAIS provided excellent overall discrimination of mortality (AUC 0.84–0.92). Among 9,269 patients with HEAIS scores was strongly predictive of mortality (AUC 0.93–0.96). CONCLUSION: Clinical assessment of injury severity using HEAIS strongly predicts hospital mortality and far exceeds conventional scores in feasibility. In contexts where traditional scoring systems are not feasible, utilization of HEAIS could facilitate improved data quality and expand access to quality improvement programming. Public Library of Science 2023-03-29 /pmc/articles/PMC10057736/ /pubmed/36989211 http://dx.doi.org/10.1371/journal.pgph.0001761 Text en © 2023 Yost et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Yost, Mark T.
Carvalho, Melissa M.
Mbuh, Lidwine
Dissak-Delon, Fanny N.
Oke, Rasheedat
Guidam, Debora
Nlong, Rene M.
Zikirou, Mbengawoh M.
Mekolo, David
Banaken, Louis H.
Juillard, Catherine
Chichom-Mefire, Alain
Christie, S. Ariane
Back to the basics: Clinical assessment yields robust mortality prediction and increased feasibility in low resource settings
title Back to the basics: Clinical assessment yields robust mortality prediction and increased feasibility in low resource settings
title_full Back to the basics: Clinical assessment yields robust mortality prediction and increased feasibility in low resource settings
title_fullStr Back to the basics: Clinical assessment yields robust mortality prediction and increased feasibility in low resource settings
title_full_unstemmed Back to the basics: Clinical assessment yields robust mortality prediction and increased feasibility in low resource settings
title_short Back to the basics: Clinical assessment yields robust mortality prediction and increased feasibility in low resource settings
title_sort back to the basics: clinical assessment yields robust mortality prediction and increased feasibility in low resource settings
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057736/
https://www.ncbi.nlm.nih.gov/pubmed/36989211
http://dx.doi.org/10.1371/journal.pgph.0001761
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