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Determinants of Equity in Coverage of Measles-Containing Vaccines in Wales, UK, during the Elimination Era

In the context of the WHO’s measles and rubella elimination targets and European Immunization Agenda 2030, this large cross-sectional study aimed to identify inequalities in measles vaccination coverage in Wales, UK. The vaccination status of individuals aged 2 to 25 years of age, alive and resident...

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Autores principales: Perry, Malorie, Cottrell, Simon, Gravenor, Michael B., Griffiths, Lucy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057771/
https://www.ncbi.nlm.nih.gov/pubmed/36992264
http://dx.doi.org/10.3390/vaccines11030680
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author Perry, Malorie
Cottrell, Simon
Gravenor, Michael B.
Griffiths, Lucy
author_facet Perry, Malorie
Cottrell, Simon
Gravenor, Michael B.
Griffiths, Lucy
author_sort Perry, Malorie
collection PubMed
description In the context of the WHO’s measles and rubella elimination targets and European Immunization Agenda 2030, this large cross-sectional study aimed to identify inequalities in measles vaccination coverage in Wales, UK. The vaccination status of individuals aged 2 to 25 years of age, alive and resident in Wales as of 31 August 2021, was ascertained through linkage of the National Community Child Health Database and primary care data. A series of predictor variables were derived from five national datasets and all analysis was carried out in the Secure Anonymised Information Linkage Databank at Swansea University. In these 648,895 individuals, coverage of the first dose of measles-containing vaccine (due at 12–13 months of age) was 97.1%, and coverage of the second dose (due at 3 years and 4 months) in 4 to 25-year-olds was 93.8%. In multivariable analysis, excluding 0.7% with known refusal, the strongest association with being unvaccinated was birth order (families with six or more children) and being born outside of the UK. Living in a deprived area, being eligible for free school meals, a lower level of maternal education, and having a recorded language other than English or Welsh were also associated with lower coverage. Some of these factors may also be associated with refusal. This knowledge can be used to target future interventions and prioritise areas for catch up in a time of limited resource.
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spelling pubmed-100577712023-03-30 Determinants of Equity in Coverage of Measles-Containing Vaccines in Wales, UK, during the Elimination Era Perry, Malorie Cottrell, Simon Gravenor, Michael B. Griffiths, Lucy Vaccines (Basel) Article In the context of the WHO’s measles and rubella elimination targets and European Immunization Agenda 2030, this large cross-sectional study aimed to identify inequalities in measles vaccination coverage in Wales, UK. The vaccination status of individuals aged 2 to 25 years of age, alive and resident in Wales as of 31 August 2021, was ascertained through linkage of the National Community Child Health Database and primary care data. A series of predictor variables were derived from five national datasets and all analysis was carried out in the Secure Anonymised Information Linkage Databank at Swansea University. In these 648,895 individuals, coverage of the first dose of measles-containing vaccine (due at 12–13 months of age) was 97.1%, and coverage of the second dose (due at 3 years and 4 months) in 4 to 25-year-olds was 93.8%. In multivariable analysis, excluding 0.7% with known refusal, the strongest association with being unvaccinated was birth order (families with six or more children) and being born outside of the UK. Living in a deprived area, being eligible for free school meals, a lower level of maternal education, and having a recorded language other than English or Welsh were also associated with lower coverage. Some of these factors may also be associated with refusal. This knowledge can be used to target future interventions and prioritise areas for catch up in a time of limited resource. MDPI 2023-03-17 /pmc/articles/PMC10057771/ /pubmed/36992264 http://dx.doi.org/10.3390/vaccines11030680 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Perry, Malorie
Cottrell, Simon
Gravenor, Michael B.
Griffiths, Lucy
Determinants of Equity in Coverage of Measles-Containing Vaccines in Wales, UK, during the Elimination Era
title Determinants of Equity in Coverage of Measles-Containing Vaccines in Wales, UK, during the Elimination Era
title_full Determinants of Equity in Coverage of Measles-Containing Vaccines in Wales, UK, during the Elimination Era
title_fullStr Determinants of Equity in Coverage of Measles-Containing Vaccines in Wales, UK, during the Elimination Era
title_full_unstemmed Determinants of Equity in Coverage of Measles-Containing Vaccines in Wales, UK, during the Elimination Era
title_short Determinants of Equity in Coverage of Measles-Containing Vaccines in Wales, UK, during the Elimination Era
title_sort determinants of equity in coverage of measles-containing vaccines in wales, uk, during the elimination era
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057771/
https://www.ncbi.nlm.nih.gov/pubmed/36992264
http://dx.doi.org/10.3390/vaccines11030680
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