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Autonomic Nervous System Adaptation and Circadian Rhythm Disturbances of the Cardiovascular System in a Ground-Based Murine Model of Spaceflight

Whether in real or simulated microgravity, Humans or animals, the kinetics of cardiovascular adaptation and its regulation by the autonomic nervous system (ANS) remain controversial. In this study, we used hindlimb unloading (HU) in 10 conscious mice. Blood pressure (BP), heart rate (HR), temperatur...

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Autores principales: Hélissen, Ophélie, Kermorgant, Marc, Déjean, Sébastien, Mercadie, Aurélie, Le Gonidec, Sophie, Zahreddine, Rana, Calise, Denis, Nasr, Nathalie, Galès, Céline, Arvanitis, Dina N., Pavy-Le Traon, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057816/
https://www.ncbi.nlm.nih.gov/pubmed/36983999
http://dx.doi.org/10.3390/life13030844
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author Hélissen, Ophélie
Kermorgant, Marc
Déjean, Sébastien
Mercadie, Aurélie
Le Gonidec, Sophie
Zahreddine, Rana
Calise, Denis
Nasr, Nathalie
Galès, Céline
Arvanitis, Dina N.
Pavy-Le Traon, Anne
author_facet Hélissen, Ophélie
Kermorgant, Marc
Déjean, Sébastien
Mercadie, Aurélie
Le Gonidec, Sophie
Zahreddine, Rana
Calise, Denis
Nasr, Nathalie
Galès, Céline
Arvanitis, Dina N.
Pavy-Le Traon, Anne
author_sort Hélissen, Ophélie
collection PubMed
description Whether in real or simulated microgravity, Humans or animals, the kinetics of cardiovascular adaptation and its regulation by the autonomic nervous system (ANS) remain controversial. In this study, we used hindlimb unloading (HU) in 10 conscious mice. Blood pressure (BP), heart rate (HR), temperature, and locomotor activity were continuously monitored with radio-telemetry, during 3 days of control, 5 days of HU, and 2 days of recovery. Six additional mice were used to assess core temperature. ANS activity was indirectly determined by analyzing both heart rate variability (HRV) and baroreflex sensitivity (BRS). Our study showed that HU induced an initial bradycardia, accompanied by an increase in vagal activity markers of HRV and BRS, together with a decrease in water intake, indicating the early adaptation to fluid redistribution. During HU, BRS was reduced; temperature and BP circadian rhythms were altered, showing a loss in day/night differences, a decrease in cycle amplitude, a drop in core body temperature, and an increase in day BP suggestive of a rise in sympathetic activity. Reloading induced resting tachycardia and a decrease in BP, vagal activity, and BRS. In addition to cardiovascular deconditioning, HU induces disruption in day/night rhythmicity of locomotor activity, temperature, and BP.
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spelling pubmed-100578162023-03-30 Autonomic Nervous System Adaptation and Circadian Rhythm Disturbances of the Cardiovascular System in a Ground-Based Murine Model of Spaceflight Hélissen, Ophélie Kermorgant, Marc Déjean, Sébastien Mercadie, Aurélie Le Gonidec, Sophie Zahreddine, Rana Calise, Denis Nasr, Nathalie Galès, Céline Arvanitis, Dina N. Pavy-Le Traon, Anne Life (Basel) Article Whether in real or simulated microgravity, Humans or animals, the kinetics of cardiovascular adaptation and its regulation by the autonomic nervous system (ANS) remain controversial. In this study, we used hindlimb unloading (HU) in 10 conscious mice. Blood pressure (BP), heart rate (HR), temperature, and locomotor activity were continuously monitored with radio-telemetry, during 3 days of control, 5 days of HU, and 2 days of recovery. Six additional mice were used to assess core temperature. ANS activity was indirectly determined by analyzing both heart rate variability (HRV) and baroreflex sensitivity (BRS). Our study showed that HU induced an initial bradycardia, accompanied by an increase in vagal activity markers of HRV and BRS, together with a decrease in water intake, indicating the early adaptation to fluid redistribution. During HU, BRS was reduced; temperature and BP circadian rhythms were altered, showing a loss in day/night differences, a decrease in cycle amplitude, a drop in core body temperature, and an increase in day BP suggestive of a rise in sympathetic activity. Reloading induced resting tachycardia and a decrease in BP, vagal activity, and BRS. In addition to cardiovascular deconditioning, HU induces disruption in day/night rhythmicity of locomotor activity, temperature, and BP. MDPI 2023-03-21 /pmc/articles/PMC10057816/ /pubmed/36983999 http://dx.doi.org/10.3390/life13030844 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hélissen, Ophélie
Kermorgant, Marc
Déjean, Sébastien
Mercadie, Aurélie
Le Gonidec, Sophie
Zahreddine, Rana
Calise, Denis
Nasr, Nathalie
Galès, Céline
Arvanitis, Dina N.
Pavy-Le Traon, Anne
Autonomic Nervous System Adaptation and Circadian Rhythm Disturbances of the Cardiovascular System in a Ground-Based Murine Model of Spaceflight
title Autonomic Nervous System Adaptation and Circadian Rhythm Disturbances of the Cardiovascular System in a Ground-Based Murine Model of Spaceflight
title_full Autonomic Nervous System Adaptation and Circadian Rhythm Disturbances of the Cardiovascular System in a Ground-Based Murine Model of Spaceflight
title_fullStr Autonomic Nervous System Adaptation and Circadian Rhythm Disturbances of the Cardiovascular System in a Ground-Based Murine Model of Spaceflight
title_full_unstemmed Autonomic Nervous System Adaptation and Circadian Rhythm Disturbances of the Cardiovascular System in a Ground-Based Murine Model of Spaceflight
title_short Autonomic Nervous System Adaptation and Circadian Rhythm Disturbances of the Cardiovascular System in a Ground-Based Murine Model of Spaceflight
title_sort autonomic nervous system adaptation and circadian rhythm disturbances of the cardiovascular system in a ground-based murine model of spaceflight
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057816/
https://www.ncbi.nlm.nih.gov/pubmed/36983999
http://dx.doi.org/10.3390/life13030844
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