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Chronic Nonbacterial Osteomyelitis of the Jaw in a 3-Year-Old Girl

Differential diagnosis of bacterial osteomyelitis (BOM) and chronic nonbacterial osteomyelitis (CNO) is challenging. Pediatric CNO can be diagnosed at around 10 years of age and when CNO cases involve only the jaw, it is difficult to make a diagnosis in a young child. A 3-year-old female developed C...

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Autores principales: Makino, Shigeru, Oshige, Hideo, Shinozuka, Jun, Imashuku, Shinsaku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057864/
https://www.ncbi.nlm.nih.gov/pubmed/36976723
http://dx.doi.org/10.3390/pediatric15010016
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author Makino, Shigeru
Oshige, Hideo
Shinozuka, Jun
Imashuku, Shinsaku
author_facet Makino, Shigeru
Oshige, Hideo
Shinozuka, Jun
Imashuku, Shinsaku
author_sort Makino, Shigeru
collection PubMed
description Differential diagnosis of bacterial osteomyelitis (BOM) and chronic nonbacterial osteomyelitis (CNO) is challenging. Pediatric CNO can be diagnosed at around 10 years of age and when CNO cases involve only the jaw, it is difficult to make a diagnosis in a young child. A 3-year-old female developed CNO at the jaw alone. She presented with no fever, right jaw pain, mild trismus, and a preauricular facial swelling around the right mandible. Computed tomography (CT) revealed a hyperostotic right mandible, with osteolytic and sclerotic changes associated with periosteal reaction. At first, we suspected BOM and antibiotics were administered. Subsequently, CNO was diagnosed, and the patient received flurbiprofen (a nonsteroidal anti-inflammatory drug (NSAIDs)). Lack of a sufficient response led to successful treatment with a combination of oral alendronate and flurbiprofen. Physicians should be aware of CNO, a rare autoinflammatory noninfectious bone disease of unknown etiology, even in young children, although the disease mostly affects older children and adolescents.
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spelling pubmed-100578642023-03-30 Chronic Nonbacterial Osteomyelitis of the Jaw in a 3-Year-Old Girl Makino, Shigeru Oshige, Hideo Shinozuka, Jun Imashuku, Shinsaku Pediatr Rep Case Report Differential diagnosis of bacterial osteomyelitis (BOM) and chronic nonbacterial osteomyelitis (CNO) is challenging. Pediatric CNO can be diagnosed at around 10 years of age and when CNO cases involve only the jaw, it is difficult to make a diagnosis in a young child. A 3-year-old female developed CNO at the jaw alone. She presented with no fever, right jaw pain, mild trismus, and a preauricular facial swelling around the right mandible. Computed tomography (CT) revealed a hyperostotic right mandible, with osteolytic and sclerotic changes associated with periosteal reaction. At first, we suspected BOM and antibiotics were administered. Subsequently, CNO was diagnosed, and the patient received flurbiprofen (a nonsteroidal anti-inflammatory drug (NSAIDs)). Lack of a sufficient response led to successful treatment with a combination of oral alendronate and flurbiprofen. Physicians should be aware of CNO, a rare autoinflammatory noninfectious bone disease of unknown etiology, even in young children, although the disease mostly affects older children and adolescents. MDPI 2023-03-02 /pmc/articles/PMC10057864/ /pubmed/36976723 http://dx.doi.org/10.3390/pediatric15010016 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Makino, Shigeru
Oshige, Hideo
Shinozuka, Jun
Imashuku, Shinsaku
Chronic Nonbacterial Osteomyelitis of the Jaw in a 3-Year-Old Girl
title Chronic Nonbacterial Osteomyelitis of the Jaw in a 3-Year-Old Girl
title_full Chronic Nonbacterial Osteomyelitis of the Jaw in a 3-Year-Old Girl
title_fullStr Chronic Nonbacterial Osteomyelitis of the Jaw in a 3-Year-Old Girl
title_full_unstemmed Chronic Nonbacterial Osteomyelitis of the Jaw in a 3-Year-Old Girl
title_short Chronic Nonbacterial Osteomyelitis of the Jaw in a 3-Year-Old Girl
title_sort chronic nonbacterial osteomyelitis of the jaw in a 3-year-old girl
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057864/
https://www.ncbi.nlm.nih.gov/pubmed/36976723
http://dx.doi.org/10.3390/pediatric15010016
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