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Chronic Nonbacterial Osteomyelitis of the Jaw in a 3-Year-Old Girl
Differential diagnosis of bacterial osteomyelitis (BOM) and chronic nonbacterial osteomyelitis (CNO) is challenging. Pediatric CNO can be diagnosed at around 10 years of age and when CNO cases involve only the jaw, it is difficult to make a diagnosis in a young child. A 3-year-old female developed C...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057864/ https://www.ncbi.nlm.nih.gov/pubmed/36976723 http://dx.doi.org/10.3390/pediatric15010016 |
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author | Makino, Shigeru Oshige, Hideo Shinozuka, Jun Imashuku, Shinsaku |
author_facet | Makino, Shigeru Oshige, Hideo Shinozuka, Jun Imashuku, Shinsaku |
author_sort | Makino, Shigeru |
collection | PubMed |
description | Differential diagnosis of bacterial osteomyelitis (BOM) and chronic nonbacterial osteomyelitis (CNO) is challenging. Pediatric CNO can be diagnosed at around 10 years of age and when CNO cases involve only the jaw, it is difficult to make a diagnosis in a young child. A 3-year-old female developed CNO at the jaw alone. She presented with no fever, right jaw pain, mild trismus, and a preauricular facial swelling around the right mandible. Computed tomography (CT) revealed a hyperostotic right mandible, with osteolytic and sclerotic changes associated with periosteal reaction. At first, we suspected BOM and antibiotics were administered. Subsequently, CNO was diagnosed, and the patient received flurbiprofen (a nonsteroidal anti-inflammatory drug (NSAIDs)). Lack of a sufficient response led to successful treatment with a combination of oral alendronate and flurbiprofen. Physicians should be aware of CNO, a rare autoinflammatory noninfectious bone disease of unknown etiology, even in young children, although the disease mostly affects older children and adolescents. |
format | Online Article Text |
id | pubmed-10057864 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100578642023-03-30 Chronic Nonbacterial Osteomyelitis of the Jaw in a 3-Year-Old Girl Makino, Shigeru Oshige, Hideo Shinozuka, Jun Imashuku, Shinsaku Pediatr Rep Case Report Differential diagnosis of bacterial osteomyelitis (BOM) and chronic nonbacterial osteomyelitis (CNO) is challenging. Pediatric CNO can be diagnosed at around 10 years of age and when CNO cases involve only the jaw, it is difficult to make a diagnosis in a young child. A 3-year-old female developed CNO at the jaw alone. She presented with no fever, right jaw pain, mild trismus, and a preauricular facial swelling around the right mandible. Computed tomography (CT) revealed a hyperostotic right mandible, with osteolytic and sclerotic changes associated with periosteal reaction. At first, we suspected BOM and antibiotics were administered. Subsequently, CNO was diagnosed, and the patient received flurbiprofen (a nonsteroidal anti-inflammatory drug (NSAIDs)). Lack of a sufficient response led to successful treatment with a combination of oral alendronate and flurbiprofen. Physicians should be aware of CNO, a rare autoinflammatory noninfectious bone disease of unknown etiology, even in young children, although the disease mostly affects older children and adolescents. MDPI 2023-03-02 /pmc/articles/PMC10057864/ /pubmed/36976723 http://dx.doi.org/10.3390/pediatric15010016 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Makino, Shigeru Oshige, Hideo Shinozuka, Jun Imashuku, Shinsaku Chronic Nonbacterial Osteomyelitis of the Jaw in a 3-Year-Old Girl |
title | Chronic Nonbacterial Osteomyelitis of the Jaw in a 3-Year-Old Girl |
title_full | Chronic Nonbacterial Osteomyelitis of the Jaw in a 3-Year-Old Girl |
title_fullStr | Chronic Nonbacterial Osteomyelitis of the Jaw in a 3-Year-Old Girl |
title_full_unstemmed | Chronic Nonbacterial Osteomyelitis of the Jaw in a 3-Year-Old Girl |
title_short | Chronic Nonbacterial Osteomyelitis of the Jaw in a 3-Year-Old Girl |
title_sort | chronic nonbacterial osteomyelitis of the jaw in a 3-year-old girl |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057864/ https://www.ncbi.nlm.nih.gov/pubmed/36976723 http://dx.doi.org/10.3390/pediatric15010016 |
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