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Mechanism of sphingolipid homeostasis revealed by structural analysis of Arabidopsis SPT-ORM1 complex

The serine palmitoyltransferase (SPT) complex catalyzes the first and rate-limiting step in sphingolipid biosynthesis in all eukaryotes. ORM/ORMDL proteins are negative regulators of SPT that respond to cellular sphingolipid levels. However, the molecular basis underlying ORM/ORMDL-dependent homeost...

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Detalles Bibliográficos
Autores principales:	Liu, Peng, Xie, Tian, Wu, Xinyue, Han, Gongshe, Gupta, Sita D., Zhang, Zike, Yue, Jian, Dong, Feitong, Gable, Kenneth, Niranjanakumari, Somashekarappa, Li, Wanyuan, Wang, Lin, Liu, Wenchen, Yao, Ruifeng, Cahoon, Edgar B., Dunn, Teresa M., Gong, Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058238/ https://www.ncbi.nlm.nih.gov/pubmed/36989369 http://dx.doi.org/10.1126/sciadv.adg0728

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