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Endocrine Disruptor Compounds in Environment: Focus on Women’s Reproductive Health and Endometriosis

Endometriosis is an estrogen-dependent gynecologic illness that has long-term effects on a woman’s fertility, physical health, and overall quality of life. Growing evidence suggests that endocrine-disrupting chemicals (EDCs) may be etiologically involved in the development and severity of the diseas...

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Autores principales: Interdonato, Livia, Siracusa, Rosalba, Fusco, Roberta, Cuzzocrea, Salvatore, Di Paola, Rosanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058284/
https://www.ncbi.nlm.nih.gov/pubmed/36982755
http://dx.doi.org/10.3390/ijms24065682
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author Interdonato, Livia
Siracusa, Rosalba
Fusco, Roberta
Cuzzocrea, Salvatore
Di Paola, Rosanna
author_facet Interdonato, Livia
Siracusa, Rosalba
Fusco, Roberta
Cuzzocrea, Salvatore
Di Paola, Rosanna
author_sort Interdonato, Livia
collection PubMed
description Endometriosis is an estrogen-dependent gynecologic illness that has long-term effects on a woman’s fertility, physical health, and overall quality of life. Growing evidence suggests that endocrine-disrupting chemicals (EDCs) may be etiologically involved in the development and severity of the disease. We consider the available human evidence on EDCs and endometriosis, limiting ourselves to studies that have individually assessed chemical amounts in women. Dioxins, BPA, Phthalates, and other endocrine disruptors, like DDT, are among the evidence indicating an environmental etiology for endometriosis. Collectively, this review describes how environmental toxins are linked to lower fertility in women, as well as a number of reproductive diseases, focusing on the pathology of endometriosis and its treatments. Importantly, this review can be used to investigate techniques for preventing the negative effects of EDC exposure.
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spelling pubmed-100582842023-03-30 Endocrine Disruptor Compounds in Environment: Focus on Women’s Reproductive Health and Endometriosis Interdonato, Livia Siracusa, Rosalba Fusco, Roberta Cuzzocrea, Salvatore Di Paola, Rosanna Int J Mol Sci Review Endometriosis is an estrogen-dependent gynecologic illness that has long-term effects on a woman’s fertility, physical health, and overall quality of life. Growing evidence suggests that endocrine-disrupting chemicals (EDCs) may be etiologically involved in the development and severity of the disease. We consider the available human evidence on EDCs and endometriosis, limiting ourselves to studies that have individually assessed chemical amounts in women. Dioxins, BPA, Phthalates, and other endocrine disruptors, like DDT, are among the evidence indicating an environmental etiology for endometriosis. Collectively, this review describes how environmental toxins are linked to lower fertility in women, as well as a number of reproductive diseases, focusing on the pathology of endometriosis and its treatments. Importantly, this review can be used to investigate techniques for preventing the negative effects of EDC exposure. MDPI 2023-03-16 /pmc/articles/PMC10058284/ /pubmed/36982755 http://dx.doi.org/10.3390/ijms24065682 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Interdonato, Livia
Siracusa, Rosalba
Fusco, Roberta
Cuzzocrea, Salvatore
Di Paola, Rosanna
Endocrine Disruptor Compounds in Environment: Focus on Women’s Reproductive Health and Endometriosis
title Endocrine Disruptor Compounds in Environment: Focus on Women’s Reproductive Health and Endometriosis
title_full Endocrine Disruptor Compounds in Environment: Focus on Women’s Reproductive Health and Endometriosis
title_fullStr Endocrine Disruptor Compounds in Environment: Focus on Women’s Reproductive Health and Endometriosis
title_full_unstemmed Endocrine Disruptor Compounds in Environment: Focus on Women’s Reproductive Health and Endometriosis
title_short Endocrine Disruptor Compounds in Environment: Focus on Women’s Reproductive Health and Endometriosis
title_sort endocrine disruptor compounds in environment: focus on women’s reproductive health and endometriosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058284/
https://www.ncbi.nlm.nih.gov/pubmed/36982755
http://dx.doi.org/10.3390/ijms24065682
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