Cargando…

Template Entrance Channel as Possible Allosteric Inhibition and Resistance Site for Quinolines Tricyclic Derivatives in RNA Dependent RNA Polymerase of Bovine Viral Diarrhea Virus

The development of potent non-nucleoside inhibitors (NNIs) could be an alternate strategy to combating infectious bovine viral diarrhea virus (BVDV), other than the traditional vaccination. RNA-dependent RNA polymerase (RdRp) is an essential enzyme for viral replication; therefore, it is one of the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Srivastava, Mitul, Mittal, Lovika, Sarmadhikari, Debapriyo, Singh, Vijay Kumar, Fais, Antonella, Kumar, Amit, Asthana, Shailendra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058290/ https://www.ncbi.nlm.nih.gov/pubmed/36986476 http://dx.doi.org/10.3390/ph16030376

Ejemplares similares

Molecular Dynamics Simulations Reveal the Interaction Fingerprint of Remdesivir Triphosphate Pivotal in Allosteric Regulation of SARS-CoV-2 RdRp
por: Srivastava, Mitul, et al.
Publicado: (2021)

Conformational Characterization of the Co-Activator Binding Site Revealed the Mechanism to Achieve the Bioactive State of FXR
por: Kumari, Anita, et al.
Publicado: (2021)

Novel tricyclic pyrrolo-quinolines as pharmacological correctors of the mutant CFTR chloride channel
por: Renda, Mario, et al.
Publicado: (2023)

Structure and RNA template requirements of Arabidopsis RNA-DEPENDENT RNA POLYMERASE 2
por: Fukudome, Akihito, et al.
Publicado: (2021)

Allosteric control of the RNA polymerase by the elongation factor RfaH
por: Svetlov, Vladimir, et al.
Publicado: (2007)

Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity
por: Di Pietro, Ornella, et al.
Publicado: (2015)

Impact of template backbone heterogeneity on RNA polymerase II transcription
por: Xu, Liang, et al.
Publicado: (2015)

A remodeled RNA polymerase II complex catalyzing viroid RNA-templated transcription
por: Dissanayaka Mudiyanselage, Shachinthaka D., et al.
Publicado: (2022)

Initiation of RNA Synthesis by the Hepatitis C Virus RNA-Dependent RNA Polymerase Is Affected by the Structure of the RNA Template
por: Reich, Stefan, et al.
Publicado: (2014)

Allosteric mechanism of transcription inhibition by NusG-dependent pausing of RNA polymerase
por: Vishwakarma, Rishi K., et al.
Publicado: (2023)

Structure based virtual screening of inhibitors for binding at the allosteric site of HCV RNA dependent RNA polymerase
por: Revikumar, Amjesh, et al.
Publicado: (2012)

Computational Study of SARS-CoV-2 RNA Dependent RNA Polymerase Allosteric Site Inhibition
por: Faisal, Shah, et al.
Publicado: (2021)

Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases
por: Kleiner, Victoria A., et al.
Publicado: (2023)

Ribonucleotides embedded in template DNA impair mitochondrial RNA polymerase progression
por: Singh, Meenakshi, et al.
Publicado: (2022)

Analysis of Template Variations on RNA Synthesis by Respiratory Syncytial Virus Polymerase
por: Cao, Dongdong, et al.
Publicado: (2022)

Allosteric pathway selection in templated assembly
por: van Galen, Martijn, et al.
Publicado: (2019)

Multi-Substituted Quinolines as HIV-1 Integrase Allosteric Inhibitors
por: Dinh, Long Phi, et al.
Publicado: (2022)

RNAs nonspecifically inhibit RNA polymerase II by preventing binding to the DNA template
por: Pai, Dave A., et al.
Publicado: (2014)

New insights into the promoterless transcription of DNA coligo templates by RNA polymerase III
por: Lama, Lodoe, et al.
Publicado: (2014)

DNA template sequence control of bacterial RNA polymerase escape from the promoter
por: Heyduk, Ewa, et al.
Publicado: (2018)

3′ end additions by T7 RNA polymerase are RNA self-templated, distributive and diverse in character—RNA-Seq analyses
por: Gholamalipour, Yasaman, et al.
Publicado: (2018)

Pharmacophore-Model-Based Drug Repurposing for the Identification of the Potential Inhibitors Targeting the Allosteric Site in Dengue Virus NS5 RNA-Dependent RNA Polymerase
por: Kumar, Sanjay, et al.
Publicado: (2022)

Allosteric Activation of SARS-CoV-2 RNA-Dependent RNA Polymerase by Remdesivir Triphosphate and Other Phosphorylated Nucleotides
por: Wang, Bing, et al.
Publicado: (2021)

Non-oncology drug (meticrane) shows anti-cancer ability in synergy with epigenetic inhibitors and appears to be involved passively in targeting cancer cells
por: Wang, Yulu, et al.
Publicado: (2023)

E. coli TraR allosterically regulates transcription initiation by altering RNA polymerase conformation
por: Chen, James, et al.
Publicado: (2019)

Entrance Qualifications
Publicado: (1899)

Circularized synthetic oligodeoxynucleotides serve as promoterless RNA polymerase III templates for small RNA generation in human cells
por: Seidl, Christine I., et al.
Publicado: (2013)

Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action
por: Tchesnokov, Egor P., et al.
Publicado: (2020)

Method for Rapid Analysis of Mutant RNA Polymerase Activity on Templates Containing Unnatural Nucleotides
por: Egorova, Tatiana, et al.
Publicado: (2021)

Structural basis of template strand deoxyuridine promoter recognition by a viral RNA polymerase
por: Fraser, Alec, et al.
Publicado: (2022)

DSIF modulates RNA polymerase II occupancy according to template G + C content
por: Deng, Ning, et al.
Publicado: (2022)

The Bicycle and Tricycle for Physicians
Publicado: (1883)

Biochemical characterization of a recombinant SARS coronavirus nsp12 RNA-dependent RNA polymerase capable of copying viral RNA templates
por: Ahn, Dae-Gyun, et al.
Publicado: (2012)

Polymerase with a protein template
por: LeBrasseur, Nicole
Publicado: (2005)

Correction: Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action
por: Tchesnokov, Egor P., et al.
Publicado: (2021)

Mini review on tricyclic compounds as an inhibitor of trypanothione reductase
por: Kumar, Suresh, et al.
Publicado: (2014)

The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family
por: van der Linden, Lonneke, et al.
Publicado: (2015)

Molecular dynamics simulation reveals the possible druggable hot-spots of USP7
por: Srivastava, Mitul, et al.
Publicado: (2018)

Entrance A 2015
por: Nunes, Rui
Publicado: (2015)

One entrance into life.
por: Morrison, J. E.
Publicado: (1975)

Cannot write session to /tmp/vufind_sessions/sess_jikud0u7huv2nhn356ubdqtnlt