Cargando…
Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors
Vaccines and drugs have helped reduce disease severity and blunt the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, ongoing virus transmission, continuous evolution, and increasing selective pressures have the potential to yield viral variants capable of resisting t...
Autores principales: | Moghadasi, Seyed Arad, Heilmann, Emmanuel, Khalil, Ahmed Magdy, Nnabuife, Christina, Kearns, Fiona L., Ye, Chengjin, Moraes, Sofia N., Costacurta, Francesco, Esler, Morgan A., Aihara, Hideki, von Laer, Dorothee, Martinez-Sobrido, Luis, Palzkill, Timothy, Amaro, Rommie E., Harris, Reuben S. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058310/ https://www.ncbi.nlm.nih.gov/pubmed/36989354 http://dx.doi.org/10.1126/sciadv.ade8778 |
Ejemplares similares
-
Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors
por: Moghadasi, Seyed Arad, et al.
Publicado: (2022) -
Developing inhibitors of the SARS-CoV-2 main protease
por: Seitz, Christian, et al.
Publicado: (2022) -
A VSV-based assay quantifies coronavirus Mpro/3CLpro/Nsp5 main protease activity and chemical inhibition
por: Heilmann, Emmanuel, et al.
Publicado: (2022) -
Studies on antiviral resistant SARS-CoV-2 Mpro mutants
por: Esler, Morgan A., et al.
Publicado: (2023) -
SARS-CoV-2 3CL(pro) mutations selected in a VSV-based system confer resistance to nirmatrelvir, ensitrelvir, and GC376
por: Heilmann, Emmanuel, et al.
Publicado: (2022)