Cargando…

Vesicoureteral Reflux and Innate Immune System: Physiology, Physiopathology, and Clinical Aspects

Vesicoureteral reflux represents one of the most concerning topics in pediatric nephrology due to its frequency, clinical expression with the potential to evolve into chronic kidney disease, and last but not least, its socio-economic implications. The presence of vesicoureteral reflux, the occurrenc...

Descripción completa

Detalles Bibliográficos
Autores principales: Colceriu, Marius-Cosmin, Aldea, Paul Luchian, Răchișan, Andreea-Liana, Clichici, Simona, Sevastre-Berghian, Alexandra, Mocan, Teodora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058356/
https://www.ncbi.nlm.nih.gov/pubmed/36983379
http://dx.doi.org/10.3390/jcm12062380
_version_ 1785016611358375936
author Colceriu, Marius-Cosmin
Aldea, Paul Luchian
Răchișan, Andreea-Liana
Clichici, Simona
Sevastre-Berghian, Alexandra
Mocan, Teodora
author_facet Colceriu, Marius-Cosmin
Aldea, Paul Luchian
Răchișan, Andreea-Liana
Clichici, Simona
Sevastre-Berghian, Alexandra
Mocan, Teodora
author_sort Colceriu, Marius-Cosmin
collection PubMed
description Vesicoureteral reflux represents one of the most concerning topics in pediatric nephrology due to its frequency, clinical expression with the potential to evolve into chronic kidney disease, and last but not least, its socio-economic implications. The presence of vesicoureteral reflux, the occurrence of urinary tract infections, and the development of reflux nephropathy, hypertension, chronic kidney disease, and finally, end-stage renal disease represent a progressive spectrum of a single physiopathological condition. For the proper management of these patients with the best clinical outcomes, and in an attempt to prevent the spread of uropathogens’ resistance to antibacterial therapy, we must better understand the physiopathology of urinary tract infections in patients with vesicoureteral reflux, and at the same time, we should acknowledge the implication and response of the innate immune system in this progressive pathological condition. The present paper focuses on theoretical aspects regarding the physiopathology of vesicoureteral reflux and the interconditionality between urinary tract infections and the innate immune system. In addition, we detailed aspects regarding cytokines, interleukins, antimicrobial peptides, and proteins involved in the innate immune response as well as their implications in the physiopathology of reflux nephropathy. New directions of study should focus on using these innate immune system effectors as diagnostic and therapeutic tools in renal pathology.
format Online
Article
Text
id pubmed-10058356
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100583562023-03-30 Vesicoureteral Reflux and Innate Immune System: Physiology, Physiopathology, and Clinical Aspects Colceriu, Marius-Cosmin Aldea, Paul Luchian Răchișan, Andreea-Liana Clichici, Simona Sevastre-Berghian, Alexandra Mocan, Teodora J Clin Med Review Vesicoureteral reflux represents one of the most concerning topics in pediatric nephrology due to its frequency, clinical expression with the potential to evolve into chronic kidney disease, and last but not least, its socio-economic implications. The presence of vesicoureteral reflux, the occurrence of urinary tract infections, and the development of reflux nephropathy, hypertension, chronic kidney disease, and finally, end-stage renal disease represent a progressive spectrum of a single physiopathological condition. For the proper management of these patients with the best clinical outcomes, and in an attempt to prevent the spread of uropathogens’ resistance to antibacterial therapy, we must better understand the physiopathology of urinary tract infections in patients with vesicoureteral reflux, and at the same time, we should acknowledge the implication and response of the innate immune system in this progressive pathological condition. The present paper focuses on theoretical aspects regarding the physiopathology of vesicoureteral reflux and the interconditionality between urinary tract infections and the innate immune system. In addition, we detailed aspects regarding cytokines, interleukins, antimicrobial peptides, and proteins involved in the innate immune response as well as their implications in the physiopathology of reflux nephropathy. New directions of study should focus on using these innate immune system effectors as diagnostic and therapeutic tools in renal pathology. MDPI 2023-03-19 /pmc/articles/PMC10058356/ /pubmed/36983379 http://dx.doi.org/10.3390/jcm12062380 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Colceriu, Marius-Cosmin
Aldea, Paul Luchian
Răchișan, Andreea-Liana
Clichici, Simona
Sevastre-Berghian, Alexandra
Mocan, Teodora
Vesicoureteral Reflux and Innate Immune System: Physiology, Physiopathology, and Clinical Aspects
title Vesicoureteral Reflux and Innate Immune System: Physiology, Physiopathology, and Clinical Aspects
title_full Vesicoureteral Reflux and Innate Immune System: Physiology, Physiopathology, and Clinical Aspects
title_fullStr Vesicoureteral Reflux and Innate Immune System: Physiology, Physiopathology, and Clinical Aspects
title_full_unstemmed Vesicoureteral Reflux and Innate Immune System: Physiology, Physiopathology, and Clinical Aspects
title_short Vesicoureteral Reflux and Innate Immune System: Physiology, Physiopathology, and Clinical Aspects
title_sort vesicoureteral reflux and innate immune system: physiology, physiopathology, and clinical aspects
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058356/
https://www.ncbi.nlm.nih.gov/pubmed/36983379
http://dx.doi.org/10.3390/jcm12062380
work_keys_str_mv AT colceriumariuscosmin vesicoureteralrefluxandinnateimmunesystemphysiologyphysiopathologyandclinicalaspects
AT aldeapaulluchian vesicoureteralrefluxandinnateimmunesystemphysiologyphysiopathologyandclinicalaspects
AT rachisanandreealiana vesicoureteralrefluxandinnateimmunesystemphysiologyphysiopathologyandclinicalaspects
AT clichicisimona vesicoureteralrefluxandinnateimmunesystemphysiologyphysiopathologyandclinicalaspects
AT sevastreberghianalexandra vesicoureteralrefluxandinnateimmunesystemphysiologyphysiopathologyandclinicalaspects
AT mocanteodora vesicoureteralrefluxandinnateimmunesystemphysiologyphysiopathologyandclinicalaspects