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Motility of Different Gastric Helicobacter spp.
Helicobacter spp., including the well-known human gastric pathogen H. pylori, can cause gastric diseases in humans and other mammals. They are Gram-negative bacteria that colonize the gastric epithelium and use their multiple flagella to move across the protective gastric mucus layer. The flagella o...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058440/ https://www.ncbi.nlm.nih.gov/pubmed/36985208 http://dx.doi.org/10.3390/microorganisms11030634 |
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author | Bansil, Rama Constantino, Maira A. Su-Arcaro, Clover Liao, Wentian Shen, Zeli Fox, James G. |
author_facet | Bansil, Rama Constantino, Maira A. Su-Arcaro, Clover Liao, Wentian Shen, Zeli Fox, James G. |
author_sort | Bansil, Rama |
collection | PubMed |
description | Helicobacter spp., including the well-known human gastric pathogen H. pylori, can cause gastric diseases in humans and other mammals. They are Gram-negative bacteria that colonize the gastric epithelium and use their multiple flagella to move across the protective gastric mucus layer. The flagella of different Helicobacter spp. vary in their location and number. This review focuses on the swimming characteristics of different species with different flagellar architectures and cell shapes. All Helicobacter spp. use a run-reverse-reorient mechanism to swim in aqueous solutions, as well as in gastric mucin. Comparisons of different strains and mutants of H. pylori varying in cell shape and the number of flagella show that their swimming speed increases with an increasing number of flagella and is somewhat enhanced with a helical cell body shape. The swimming mechanism of H. suis, which has bipolar flagella, is more complex than that of unipolar H. pylori. H. suis exhibits multiple modes of flagellar orientation while swimming. The pH-dependent viscosity and gelation of gastric mucin significantly impact the motility of Helicobacter spp. In the absence of urea, these bacteria do not swim in mucin gel at pH < 4, even though their flagellar bundle rotates. |
format | Online Article Text |
id | pubmed-10058440 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100584402023-03-30 Motility of Different Gastric Helicobacter spp. Bansil, Rama Constantino, Maira A. Su-Arcaro, Clover Liao, Wentian Shen, Zeli Fox, James G. Microorganisms Review Helicobacter spp., including the well-known human gastric pathogen H. pylori, can cause gastric diseases in humans and other mammals. They are Gram-negative bacteria that colonize the gastric epithelium and use their multiple flagella to move across the protective gastric mucus layer. The flagella of different Helicobacter spp. vary in their location and number. This review focuses on the swimming characteristics of different species with different flagellar architectures and cell shapes. All Helicobacter spp. use a run-reverse-reorient mechanism to swim in aqueous solutions, as well as in gastric mucin. Comparisons of different strains and mutants of H. pylori varying in cell shape and the number of flagella show that their swimming speed increases with an increasing number of flagella and is somewhat enhanced with a helical cell body shape. The swimming mechanism of H. suis, which has bipolar flagella, is more complex than that of unipolar H. pylori. H. suis exhibits multiple modes of flagellar orientation while swimming. The pH-dependent viscosity and gelation of gastric mucin significantly impact the motility of Helicobacter spp. In the absence of urea, these bacteria do not swim in mucin gel at pH < 4, even though their flagellar bundle rotates. MDPI 2023-03-01 /pmc/articles/PMC10058440/ /pubmed/36985208 http://dx.doi.org/10.3390/microorganisms11030634 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bansil, Rama Constantino, Maira A. Su-Arcaro, Clover Liao, Wentian Shen, Zeli Fox, James G. Motility of Different Gastric Helicobacter spp. |
title | Motility of Different Gastric Helicobacter spp. |
title_full | Motility of Different Gastric Helicobacter spp. |
title_fullStr | Motility of Different Gastric Helicobacter spp. |
title_full_unstemmed | Motility of Different Gastric Helicobacter spp. |
title_short | Motility of Different Gastric Helicobacter spp. |
title_sort | motility of different gastric helicobacter spp. |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058440/ https://www.ncbi.nlm.nih.gov/pubmed/36985208 http://dx.doi.org/10.3390/microorganisms11030634 |
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