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Global and Partial Effect Assessment in Metabolic Syndrome Explored by Metabolomics
In nutrition and health research, untargeted metabolomics is actually analyzed simultaneously with clinical data to improve prediction and better understand pathological status. This can be modeled using a multiblock supervised model with several input data blocks (metabolomics, clinical data) being...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058487/ https://www.ncbi.nlm.nih.gov/pubmed/36984813 http://dx.doi.org/10.3390/metabo13030373 |
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author | Brandolini-Bunlon, Marion Jaillais, Benoit Cariou, Véronique Comte, Blandine Pujos-Guillot, Estelle Vigneau, Evelyne |
author_facet | Brandolini-Bunlon, Marion Jaillais, Benoit Cariou, Véronique Comte, Blandine Pujos-Guillot, Estelle Vigneau, Evelyne |
author_sort | Brandolini-Bunlon, Marion |
collection | PubMed |
description | In nutrition and health research, untargeted metabolomics is actually analyzed simultaneously with clinical data to improve prediction and better understand pathological status. This can be modeled using a multiblock supervised model with several input data blocks (metabolomics, clinical data) being potential predictors of the outcome to be explained. Alternatively, this configuration can be represented with a path diagram where the input blocks are each connected by links directed to the outcome—as in multiblock supervised modeling—and are also related to each other, thus allowing one to account for block effects. On the basis of a path model, we show herein how to estimate the effect of an input block, either on its own or conditionally to other(s), on the output response, respectively called “global” and “partial” effects, by percentages of explained variance in dedicated PLS regression models. These effects have been computed in two different path diagrams in a case study relative to metabolic syndrome, involving metabolomics and clinical data from an older men′s cohort (NuAge). From the two effects associated with each path, the results highlighted the complementary information provided by metabolomics to clinical data and, reciprocally, in the metabolic syndrome exploration. |
format | Online Article Text |
id | pubmed-10058487 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100584872023-03-30 Global and Partial Effect Assessment in Metabolic Syndrome Explored by Metabolomics Brandolini-Bunlon, Marion Jaillais, Benoit Cariou, Véronique Comte, Blandine Pujos-Guillot, Estelle Vigneau, Evelyne Metabolites Article In nutrition and health research, untargeted metabolomics is actually analyzed simultaneously with clinical data to improve prediction and better understand pathological status. This can be modeled using a multiblock supervised model with several input data blocks (metabolomics, clinical data) being potential predictors of the outcome to be explained. Alternatively, this configuration can be represented with a path diagram where the input blocks are each connected by links directed to the outcome—as in multiblock supervised modeling—and are also related to each other, thus allowing one to account for block effects. On the basis of a path model, we show herein how to estimate the effect of an input block, either on its own or conditionally to other(s), on the output response, respectively called “global” and “partial” effects, by percentages of explained variance in dedicated PLS regression models. These effects have been computed in two different path diagrams in a case study relative to metabolic syndrome, involving metabolomics and clinical data from an older men′s cohort (NuAge). From the two effects associated with each path, the results highlighted the complementary information provided by metabolomics to clinical data and, reciprocally, in the metabolic syndrome exploration. MDPI 2023-03-02 /pmc/articles/PMC10058487/ /pubmed/36984813 http://dx.doi.org/10.3390/metabo13030373 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Brandolini-Bunlon, Marion Jaillais, Benoit Cariou, Véronique Comte, Blandine Pujos-Guillot, Estelle Vigneau, Evelyne Global and Partial Effect Assessment in Metabolic Syndrome Explored by Metabolomics |
title | Global and Partial Effect Assessment in Metabolic Syndrome Explored by Metabolomics |
title_full | Global and Partial Effect Assessment in Metabolic Syndrome Explored by Metabolomics |
title_fullStr | Global and Partial Effect Assessment in Metabolic Syndrome Explored by Metabolomics |
title_full_unstemmed | Global and Partial Effect Assessment in Metabolic Syndrome Explored by Metabolomics |
title_short | Global and Partial Effect Assessment in Metabolic Syndrome Explored by Metabolomics |
title_sort | global and partial effect assessment in metabolic syndrome explored by metabolomics |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058487/ https://www.ncbi.nlm.nih.gov/pubmed/36984813 http://dx.doi.org/10.3390/metabo13030373 |
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