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Duodenal Gangliocytic Paragangliomas—Case Series and Literature Review
Duodenal gangliocytic paragangliomas are rare neuroendocrine tumors primarily localized in the periampullary area. Though mostly asymptomatic, they can present with various symptoms, most often jaundice, anemia and abdominal pain. The present paper is a case series report, describing our personal ex...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058500/ https://www.ncbi.nlm.nih.gov/pubmed/36983753 http://dx.doi.org/10.3390/life13030597 |
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author | Stan-Ilie, Madalina Şandru, Vasile Plotogea, Oana-Mihaela Rînja, Ecaterina Pavel, Christopher Constantinescu, Gabriel Negreanu, Lucian Paduraru, Dan Nicolae Bolocan, Alexandra Andronic, Octavian Davitoiu, Dragos Bălan, Gheorghe G. Constantinescu, Alexandru |
author_facet | Stan-Ilie, Madalina Şandru, Vasile Plotogea, Oana-Mihaela Rînja, Ecaterina Pavel, Christopher Constantinescu, Gabriel Negreanu, Lucian Paduraru, Dan Nicolae Bolocan, Alexandra Andronic, Octavian Davitoiu, Dragos Bălan, Gheorghe G. Constantinescu, Alexandru |
author_sort | Stan-Ilie, Madalina |
collection | PubMed |
description | Duodenal gangliocytic paragangliomas are rare neuroendocrine tumors primarily localized in the periampullary area. Though mostly asymptomatic, they can present with various symptoms, most often jaundice, anemia and abdominal pain. The present paper is a case series report, describing our personal experience with patients presenting to the Emergency Unit with different symptoms due to duodenal gangliocytic paraganglioma. Endoscopic resection is safe and indicated in most of the cases, being also associated with lower medical costs. EUS plays a central role in the pre-resection management and in surveillance, and immunostaining is decisive to ascertain the tumor histologic origin. In addition to reporting our experience, we researched the literature regarding these rare tumors and performed a comprehensive review. |
format | Online Article Text |
id | pubmed-10058500 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100585002023-03-30 Duodenal Gangliocytic Paragangliomas—Case Series and Literature Review Stan-Ilie, Madalina Şandru, Vasile Plotogea, Oana-Mihaela Rînja, Ecaterina Pavel, Christopher Constantinescu, Gabriel Negreanu, Lucian Paduraru, Dan Nicolae Bolocan, Alexandra Andronic, Octavian Davitoiu, Dragos Bălan, Gheorghe G. Constantinescu, Alexandru Life (Basel) Case Report Duodenal gangliocytic paragangliomas are rare neuroendocrine tumors primarily localized in the periampullary area. Though mostly asymptomatic, they can present with various symptoms, most often jaundice, anemia and abdominal pain. The present paper is a case series report, describing our personal experience with patients presenting to the Emergency Unit with different symptoms due to duodenal gangliocytic paraganglioma. Endoscopic resection is safe and indicated in most of the cases, being also associated with lower medical costs. EUS plays a central role in the pre-resection management and in surveillance, and immunostaining is decisive to ascertain the tumor histologic origin. In addition to reporting our experience, we researched the literature regarding these rare tumors and performed a comprehensive review. MDPI 2023-02-21 /pmc/articles/PMC10058500/ /pubmed/36983753 http://dx.doi.org/10.3390/life13030597 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Stan-Ilie, Madalina Şandru, Vasile Plotogea, Oana-Mihaela Rînja, Ecaterina Pavel, Christopher Constantinescu, Gabriel Negreanu, Lucian Paduraru, Dan Nicolae Bolocan, Alexandra Andronic, Octavian Davitoiu, Dragos Bălan, Gheorghe G. Constantinescu, Alexandru Duodenal Gangliocytic Paragangliomas—Case Series and Literature Review |
title | Duodenal Gangliocytic Paragangliomas—Case Series and Literature Review |
title_full | Duodenal Gangliocytic Paragangliomas—Case Series and Literature Review |
title_fullStr | Duodenal Gangliocytic Paragangliomas—Case Series and Literature Review |
title_full_unstemmed | Duodenal Gangliocytic Paragangliomas—Case Series and Literature Review |
title_short | Duodenal Gangliocytic Paragangliomas—Case Series and Literature Review |
title_sort | duodenal gangliocytic paragangliomas—case series and literature review |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058500/ https://www.ncbi.nlm.nih.gov/pubmed/36983753 http://dx.doi.org/10.3390/life13030597 |
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