Characterization of Live-Attenuated Powassan Virus Vaccine Candidates Identifies an Efficacious Prime-Boost Strategy for Mitigating Powassan Virus Disease in a Murine Model

Powassan virus (POWV) is an emerging tick-borne virus and cause of lethal encephalitis in humans. The lack of treatment or prevention strategies for POWV disease underscores the need for an effective POWV vaccine. Here, we took two independent approaches to develop vaccine candidates. First, we reco...

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Detalles Bibliográficos
Autores principales: Cheung, Andrew M., Yip, Elaine Z., Ashbrook, Alison W., Goonawardane, Niluka, Quirk, Corrine, Rice, Charles M., MacDonald, Margaret R., Hoffmann, Hans-Heinrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058527/
https://www.ncbi.nlm.nih.gov/pubmed/36992196
http://dx.doi.org/10.3390/vaccines11030612

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