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Biodegradable Block Poly(ester amine)s with Pendant Hydroxyl Groups for Biomedical Applications
The article presents the results of the synthesis and characteristics of the amphiphilic block terpolymers, built of a hydrophilic polyesteramine block, and hydrophobic blocks made of lactidyl and glycolidyl units. These terpolymers were obtained during the copolymerization of L-lactide with glycoli...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058592/ https://www.ncbi.nlm.nih.gov/pubmed/36987253 http://dx.doi.org/10.3390/polym15061473 |
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author | Śmigiel-Gac, Natalia Smola-Dmochowska, Anna Janeczek, Henryk Dobrzyński, Piotr |
author_facet | Śmigiel-Gac, Natalia Smola-Dmochowska, Anna Janeczek, Henryk Dobrzyński, Piotr |
author_sort | Śmigiel-Gac, Natalia |
collection | PubMed |
description | The article presents the results of the synthesis and characteristics of the amphiphilic block terpolymers, built of a hydrophilic polyesteramine block, and hydrophobic blocks made of lactidyl and glycolidyl units. These terpolymers were obtained during the copolymerization of L-lactide with glycolide carried out in the presence of previously produced macroinitiators with protected amine and hydroxyl groups. The terpolymers were prepared to produce a biodegradable and biocompatible material containing active hydroxyl and/or amino groups, with strong antibacterial properties and high surface wettability by water. The control of the reaction course, the process of deprotection of functional groups, and the properties of the obtained terpolymers were made based on (1)H NMR, FTIR, GPC, and DSC tests. Terpolymers differed in the content of amino and hydroxyl groups. The values of average molecular mass oscillated from about 5000 g/mol to less than 15,000 g/mol. Depending on the length of the hydrophilic block and its composition, the value of the contact angle ranged from 50° to 20°. The terpolymers containing amino groups, capable of forming strong intra- and intermolecular bonds, show a high degree of crystallinity. The endotherm responsible for the melting of L-lactidyl semicrystalline regions appeared in the range from about 90 °C to close to 170 °C, with a heat of fusion from about 15 J/mol to over 60 J/mol. |
format | Online Article Text |
id | pubmed-10058592 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100585922023-03-30 Biodegradable Block Poly(ester amine)s with Pendant Hydroxyl Groups for Biomedical Applications Śmigiel-Gac, Natalia Smola-Dmochowska, Anna Janeczek, Henryk Dobrzyński, Piotr Polymers (Basel) Article The article presents the results of the synthesis and characteristics of the amphiphilic block terpolymers, built of a hydrophilic polyesteramine block, and hydrophobic blocks made of lactidyl and glycolidyl units. These terpolymers were obtained during the copolymerization of L-lactide with glycolide carried out in the presence of previously produced macroinitiators with protected amine and hydroxyl groups. The terpolymers were prepared to produce a biodegradable and biocompatible material containing active hydroxyl and/or amino groups, with strong antibacterial properties and high surface wettability by water. The control of the reaction course, the process of deprotection of functional groups, and the properties of the obtained terpolymers were made based on (1)H NMR, FTIR, GPC, and DSC tests. Terpolymers differed in the content of amino and hydroxyl groups. The values of average molecular mass oscillated from about 5000 g/mol to less than 15,000 g/mol. Depending on the length of the hydrophilic block and its composition, the value of the contact angle ranged from 50° to 20°. The terpolymers containing amino groups, capable of forming strong intra- and intermolecular bonds, show a high degree of crystallinity. The endotherm responsible for the melting of L-lactidyl semicrystalline regions appeared in the range from about 90 °C to close to 170 °C, with a heat of fusion from about 15 J/mol to over 60 J/mol. MDPI 2023-03-16 /pmc/articles/PMC10058592/ /pubmed/36987253 http://dx.doi.org/10.3390/polym15061473 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Śmigiel-Gac, Natalia Smola-Dmochowska, Anna Janeczek, Henryk Dobrzyński, Piotr Biodegradable Block Poly(ester amine)s with Pendant Hydroxyl Groups for Biomedical Applications |
title | Biodegradable Block Poly(ester amine)s with Pendant Hydroxyl Groups for Biomedical Applications |
title_full | Biodegradable Block Poly(ester amine)s with Pendant Hydroxyl Groups for Biomedical Applications |
title_fullStr | Biodegradable Block Poly(ester amine)s with Pendant Hydroxyl Groups for Biomedical Applications |
title_full_unstemmed | Biodegradable Block Poly(ester amine)s with Pendant Hydroxyl Groups for Biomedical Applications |
title_short | Biodegradable Block Poly(ester amine)s with Pendant Hydroxyl Groups for Biomedical Applications |
title_sort | biodegradable block poly(ester amine)s with pendant hydroxyl groups for biomedical applications |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058592/ https://www.ncbi.nlm.nih.gov/pubmed/36987253 http://dx.doi.org/10.3390/polym15061473 |
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