Cargando…
The Potential of ICP-MS as a Complementary Tool in Nanoparticle–Protein Corona Analysis
The prolific applicability of nanomaterials has made them a common citizen in biological systems, where they interact with proteins forming a biological corona complex. These complexes drive the interaction of nanomaterials with and within the cells, bringing forward numerous potential applications...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058595/ https://www.ncbi.nlm.nih.gov/pubmed/36986026 http://dx.doi.org/10.3390/nano13061132 |
_version_ | 1785016669544906752 |
---|---|
author | Fuentes-Cervantes, Ana Ruiz Allica, Julia Calderón Celis, Francisco Costa-Fernández, José M. Ruiz Encinar, Jorge |
author_facet | Fuentes-Cervantes, Ana Ruiz Allica, Julia Calderón Celis, Francisco Costa-Fernández, José M. Ruiz Encinar, Jorge |
author_sort | Fuentes-Cervantes, Ana |
collection | PubMed |
description | The prolific applicability of nanomaterials has made them a common citizen in biological systems, where they interact with proteins forming a biological corona complex. These complexes drive the interaction of nanomaterials with and within the cells, bringing forward numerous potential applications in nanobiomedicine, but also arising toxicological issues and concerns. Proper characterization of the protein corona complex is a great challenge typically handled with the combination of several techniques. Surprisingly, despite inductively coupled plasma mass spectrometry (ICP-MS) being a powerful quantitative technique whose application in nanomaterials characterization and quantification has been consolidated in the last decade, its application to nanoparticle–protein corona studies is scarce. Furthermore, in the last decades, ICP-MS has experienced a turning point in its capabilities for protein quantification through sulfur detection, hence becoming a generic quantitative detector. In this regard, we would like to introduce the potential of ICP-MS in the nanoparticle protein corona complex characterization and quantification complementary to current methods and protocols. |
format | Online Article Text |
id | pubmed-10058595 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100585952023-03-30 The Potential of ICP-MS as a Complementary Tool in Nanoparticle–Protein Corona Analysis Fuentes-Cervantes, Ana Ruiz Allica, Julia Calderón Celis, Francisco Costa-Fernández, José M. Ruiz Encinar, Jorge Nanomaterials (Basel) Review The prolific applicability of nanomaterials has made them a common citizen in biological systems, where they interact with proteins forming a biological corona complex. These complexes drive the interaction of nanomaterials with and within the cells, bringing forward numerous potential applications in nanobiomedicine, but also arising toxicological issues and concerns. Proper characterization of the protein corona complex is a great challenge typically handled with the combination of several techniques. Surprisingly, despite inductively coupled plasma mass spectrometry (ICP-MS) being a powerful quantitative technique whose application in nanomaterials characterization and quantification has been consolidated in the last decade, its application to nanoparticle–protein corona studies is scarce. Furthermore, in the last decades, ICP-MS has experienced a turning point in its capabilities for protein quantification through sulfur detection, hence becoming a generic quantitative detector. In this regard, we would like to introduce the potential of ICP-MS in the nanoparticle protein corona complex characterization and quantification complementary to current methods and protocols. MDPI 2023-03-22 /pmc/articles/PMC10058595/ /pubmed/36986026 http://dx.doi.org/10.3390/nano13061132 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Fuentes-Cervantes, Ana Ruiz Allica, Julia Calderón Celis, Francisco Costa-Fernández, José M. Ruiz Encinar, Jorge The Potential of ICP-MS as a Complementary Tool in Nanoparticle–Protein Corona Analysis |
title | The Potential of ICP-MS as a Complementary Tool in Nanoparticle–Protein Corona Analysis |
title_full | The Potential of ICP-MS as a Complementary Tool in Nanoparticle–Protein Corona Analysis |
title_fullStr | The Potential of ICP-MS as a Complementary Tool in Nanoparticle–Protein Corona Analysis |
title_full_unstemmed | The Potential of ICP-MS as a Complementary Tool in Nanoparticle–Protein Corona Analysis |
title_short | The Potential of ICP-MS as a Complementary Tool in Nanoparticle–Protein Corona Analysis |
title_sort | potential of icp-ms as a complementary tool in nanoparticle–protein corona analysis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058595/ https://www.ncbi.nlm.nih.gov/pubmed/36986026 http://dx.doi.org/10.3390/nano13061132 |
work_keys_str_mv | AT fuentescervantesana thepotentialoficpmsasacomplementarytoolinnanoparticleproteincoronaanalysis AT ruizallicajulia thepotentialoficpmsasacomplementarytoolinnanoparticleproteincoronaanalysis AT calderoncelisfrancisco thepotentialoficpmsasacomplementarytoolinnanoparticleproteincoronaanalysis AT costafernandezjosem thepotentialoficpmsasacomplementarytoolinnanoparticleproteincoronaanalysis AT ruizencinarjorge thepotentialoficpmsasacomplementarytoolinnanoparticleproteincoronaanalysis AT fuentescervantesana potentialoficpmsasacomplementarytoolinnanoparticleproteincoronaanalysis AT ruizallicajulia potentialoficpmsasacomplementarytoolinnanoparticleproteincoronaanalysis AT calderoncelisfrancisco potentialoficpmsasacomplementarytoolinnanoparticleproteincoronaanalysis AT costafernandezjosem potentialoficpmsasacomplementarytoolinnanoparticleproteincoronaanalysis AT ruizencinarjorge potentialoficpmsasacomplementarytoolinnanoparticleproteincoronaanalysis |