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The Potential of ICP-MS as a Complementary Tool in Nanoparticle–Protein Corona Analysis

The prolific applicability of nanomaterials has made them a common citizen in biological systems, where they interact with proteins forming a biological corona complex. These complexes drive the interaction of nanomaterials with and within the cells, bringing forward numerous potential applications...

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Autores principales: Fuentes-Cervantes, Ana, Ruiz Allica, Julia, Calderón Celis, Francisco, Costa-Fernández, José M., Ruiz Encinar, Jorge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058595/
https://www.ncbi.nlm.nih.gov/pubmed/36986026
http://dx.doi.org/10.3390/nano13061132
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author Fuentes-Cervantes, Ana
Ruiz Allica, Julia
Calderón Celis, Francisco
Costa-Fernández, José M.
Ruiz Encinar, Jorge
author_facet Fuentes-Cervantes, Ana
Ruiz Allica, Julia
Calderón Celis, Francisco
Costa-Fernández, José M.
Ruiz Encinar, Jorge
author_sort Fuentes-Cervantes, Ana
collection PubMed
description The prolific applicability of nanomaterials has made them a common citizen in biological systems, where they interact with proteins forming a biological corona complex. These complexes drive the interaction of nanomaterials with and within the cells, bringing forward numerous potential applications in nanobiomedicine, but also arising toxicological issues and concerns. Proper characterization of the protein corona complex is a great challenge typically handled with the combination of several techniques. Surprisingly, despite inductively coupled plasma mass spectrometry (ICP-MS) being a powerful quantitative technique whose application in nanomaterials characterization and quantification has been consolidated in the last decade, its application to nanoparticle–protein corona studies is scarce. Furthermore, in the last decades, ICP-MS has experienced a turning point in its capabilities for protein quantification through sulfur detection, hence becoming a generic quantitative detector. In this regard, we would like to introduce the potential of ICP-MS in the nanoparticle protein corona complex characterization and quantification complementary to current methods and protocols.
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spelling pubmed-100585952023-03-30 The Potential of ICP-MS as a Complementary Tool in Nanoparticle–Protein Corona Analysis Fuentes-Cervantes, Ana Ruiz Allica, Julia Calderón Celis, Francisco Costa-Fernández, José M. Ruiz Encinar, Jorge Nanomaterials (Basel) Review The prolific applicability of nanomaterials has made them a common citizen in biological systems, where they interact with proteins forming a biological corona complex. These complexes drive the interaction of nanomaterials with and within the cells, bringing forward numerous potential applications in nanobiomedicine, but also arising toxicological issues and concerns. Proper characterization of the protein corona complex is a great challenge typically handled with the combination of several techniques. Surprisingly, despite inductively coupled plasma mass spectrometry (ICP-MS) being a powerful quantitative technique whose application in nanomaterials characterization and quantification has been consolidated in the last decade, its application to nanoparticle–protein corona studies is scarce. Furthermore, in the last decades, ICP-MS has experienced a turning point in its capabilities for protein quantification through sulfur detection, hence becoming a generic quantitative detector. In this regard, we would like to introduce the potential of ICP-MS in the nanoparticle protein corona complex characterization and quantification complementary to current methods and protocols. MDPI 2023-03-22 /pmc/articles/PMC10058595/ /pubmed/36986026 http://dx.doi.org/10.3390/nano13061132 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fuentes-Cervantes, Ana
Ruiz Allica, Julia
Calderón Celis, Francisco
Costa-Fernández, José M.
Ruiz Encinar, Jorge
The Potential of ICP-MS as a Complementary Tool in Nanoparticle–Protein Corona Analysis
title The Potential of ICP-MS as a Complementary Tool in Nanoparticle–Protein Corona Analysis
title_full The Potential of ICP-MS as a Complementary Tool in Nanoparticle–Protein Corona Analysis
title_fullStr The Potential of ICP-MS as a Complementary Tool in Nanoparticle–Protein Corona Analysis
title_full_unstemmed The Potential of ICP-MS as a Complementary Tool in Nanoparticle–Protein Corona Analysis
title_short The Potential of ICP-MS as a Complementary Tool in Nanoparticle–Protein Corona Analysis
title_sort potential of icp-ms as a complementary tool in nanoparticle–protein corona analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058595/
https://www.ncbi.nlm.nih.gov/pubmed/36986026
http://dx.doi.org/10.3390/nano13061132
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