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Phytochemical-Based Nanomaterials against Antibiotic-Resistant Bacteria: An Updated Review

Antibiotic-resistant bacteria (ARB) is a growing global health threat, leading to the search for alternative strategies to combat bacterial infections. Phytochemicals, which are naturally occurring compounds found in plants, have shown potential as antimicrobial agents; however, therapy with these a...

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Autores principales: Díaz-Puertas, Rocío, Álvarez-Martínez, Francisco Javier, Falco, Alberto, Barrajón-Catalán, Enrique, Mallavia, Ricardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058650/
https://www.ncbi.nlm.nih.gov/pubmed/36987172
http://dx.doi.org/10.3390/polym15061392
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author Díaz-Puertas, Rocío
Álvarez-Martínez, Francisco Javier
Falco, Alberto
Barrajón-Catalán, Enrique
Mallavia, Ricardo
author_facet Díaz-Puertas, Rocío
Álvarez-Martínez, Francisco Javier
Falco, Alberto
Barrajón-Catalán, Enrique
Mallavia, Ricardo
author_sort Díaz-Puertas, Rocío
collection PubMed
description Antibiotic-resistant bacteria (ARB) is a growing global health threat, leading to the search for alternative strategies to combat bacterial infections. Phytochemicals, which are naturally occurring compounds found in plants, have shown potential as antimicrobial agents; however, therapy with these agents has certain limitations. The use of nanotechnology combined with antibacterial phytochemicals could help achieve greater antibacterial capacity against ARB by providing improved mechanical, physicochemical, biopharmaceutical, bioavailability, morphological or release properties. This review aims to provide an updated overview of the current state of research on the use of phytochemical-based nanomaterials for the treatment against ARB, with a special focus on polymeric nanofibers and nanoparticles. The review discusses the various types of phytochemicals that have been incorporated into different nanomaterials, the methods used to synthesize these materials, and the results of studies evaluating their antimicrobial activity. The challenges and limitations of using phytochemical-based nanomaterials, as well as future directions for research in this field, are also considered here. Overall, this review highlights the potential of phytochemical-based nanomaterials as a promising strategy for the treatment against ARB, but also stresses the need for further studies to fully understand their mechanisms of action and optimize their use in clinical settings.
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spelling pubmed-100586502023-03-30 Phytochemical-Based Nanomaterials against Antibiotic-Resistant Bacteria: An Updated Review Díaz-Puertas, Rocío Álvarez-Martínez, Francisco Javier Falco, Alberto Barrajón-Catalán, Enrique Mallavia, Ricardo Polymers (Basel) Review Antibiotic-resistant bacteria (ARB) is a growing global health threat, leading to the search for alternative strategies to combat bacterial infections. Phytochemicals, which are naturally occurring compounds found in plants, have shown potential as antimicrobial agents; however, therapy with these agents has certain limitations. The use of nanotechnology combined with antibacterial phytochemicals could help achieve greater antibacterial capacity against ARB by providing improved mechanical, physicochemical, biopharmaceutical, bioavailability, morphological or release properties. This review aims to provide an updated overview of the current state of research on the use of phytochemical-based nanomaterials for the treatment against ARB, with a special focus on polymeric nanofibers and nanoparticles. The review discusses the various types of phytochemicals that have been incorporated into different nanomaterials, the methods used to synthesize these materials, and the results of studies evaluating their antimicrobial activity. The challenges and limitations of using phytochemical-based nanomaterials, as well as future directions for research in this field, are also considered here. Overall, this review highlights the potential of phytochemical-based nanomaterials as a promising strategy for the treatment against ARB, but also stresses the need for further studies to fully understand their mechanisms of action and optimize their use in clinical settings. MDPI 2023-03-10 /pmc/articles/PMC10058650/ /pubmed/36987172 http://dx.doi.org/10.3390/polym15061392 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Díaz-Puertas, Rocío
Álvarez-Martínez, Francisco Javier
Falco, Alberto
Barrajón-Catalán, Enrique
Mallavia, Ricardo
Phytochemical-Based Nanomaterials against Antibiotic-Resistant Bacteria: An Updated Review
title Phytochemical-Based Nanomaterials against Antibiotic-Resistant Bacteria: An Updated Review
title_full Phytochemical-Based Nanomaterials against Antibiotic-Resistant Bacteria: An Updated Review
title_fullStr Phytochemical-Based Nanomaterials against Antibiotic-Resistant Bacteria: An Updated Review
title_full_unstemmed Phytochemical-Based Nanomaterials against Antibiotic-Resistant Bacteria: An Updated Review
title_short Phytochemical-Based Nanomaterials against Antibiotic-Resistant Bacteria: An Updated Review
title_sort phytochemical-based nanomaterials against antibiotic-resistant bacteria: an updated review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058650/
https://www.ncbi.nlm.nih.gov/pubmed/36987172
http://dx.doi.org/10.3390/polym15061392
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AT barrajoncatalanenrique phytochemicalbasednanomaterialsagainstantibioticresistantbacteriaanupdatedreview
AT mallaviaricardo phytochemicalbasednanomaterialsagainstantibioticresistantbacteriaanupdatedreview