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Clinical Features and Outcomes of Japanese Patients with Giant Cell Arteritis: A Comparison with Takayasu Arteritis

Background: Giant cell arteritis (GCA) and Takayasu arteritis (TA) are distinct types of large-vessel vasculitis; however, the clinical features of the diseases have some similarities. Limited data are available regarding Japanese patients with GCA and TA. The present study aimed to compare the clin...

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Autores principales: Yoshida, Shuhei, Suzuki, Eiji, Sumichika, Yuya, Saito, Kenji, Matsumoto, Haruki, Temmoku, Jumpei, Fujita, Yuya, Matsuoka, Naoki, Asano, Tomoyuki, Sato, Shuzo, Watanabe, Hiroshi, Migita, Kiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058730/
https://www.ncbi.nlm.nih.gov/pubmed/36983569
http://dx.doi.org/10.3390/jpm13030387
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author Yoshida, Shuhei
Suzuki, Eiji
Sumichika, Yuya
Saito, Kenji
Matsumoto, Haruki
Temmoku, Jumpei
Fujita, Yuya
Matsuoka, Naoki
Asano, Tomoyuki
Sato, Shuzo
Watanabe, Hiroshi
Migita, Kiyoshi
author_facet Yoshida, Shuhei
Suzuki, Eiji
Sumichika, Yuya
Saito, Kenji
Matsumoto, Haruki
Temmoku, Jumpei
Fujita, Yuya
Matsuoka, Naoki
Asano, Tomoyuki
Sato, Shuzo
Watanabe, Hiroshi
Migita, Kiyoshi
author_sort Yoshida, Shuhei
collection PubMed
description Background: Giant cell arteritis (GCA) and Takayasu arteritis (TA) are distinct types of large-vessel vasculitis; however, the clinical features of the diseases have some similarities. Limited data are available regarding Japanese patients with GCA and TA. The present study aimed to compare the clinical features and outcomes of Japanese patients with GCA and TA and the effects of large vessel involvement (LVI). Methods: We performed a retrospective cohort study of the patients with GCA (n = 15) and TA (n = 30) who visited our department from April 2012 to June 2022. Signs and symptoms attributed to the disease, treatment, clinical outcomes, and mortality were recorded using a standardized database. Results: The median age of onset was significantly higher in the GCA group at 24 years (range, 16–72 years) in the TA group and 77 years (range, 57–89 years) in the GCA group (p < 0.001). There were no significant differences in survival rates or the cumulative rates of cardiovascular events between the GCA and TA groups. However, relapse-free survival rates were significantly higher in patients with GCA than in patients with TA. Seven of the 15 patients with GCA had large vessel involvement, which did not affect the survival rates. Prednisolone (PSL) doses were significantly decreased after induction therapy in both groups, and the rates of achieving steroid tapering (PSL < 5.0 mg/day) were significantly higher in patients with GCA compared with those in patients with TA. Conclusions: Our study demonstrated no significant difference in the survival rates of Japanese patients with GCA and TA. The relapse-free survival rates were significantly higher in the GCA group than in the TA group. LVI may not be associated with disease relapse or survival rate in Japanese patients with GCA.
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spelling pubmed-100587302023-03-30 Clinical Features and Outcomes of Japanese Patients with Giant Cell Arteritis: A Comparison with Takayasu Arteritis Yoshida, Shuhei Suzuki, Eiji Sumichika, Yuya Saito, Kenji Matsumoto, Haruki Temmoku, Jumpei Fujita, Yuya Matsuoka, Naoki Asano, Tomoyuki Sato, Shuzo Watanabe, Hiroshi Migita, Kiyoshi J Pers Med Article Background: Giant cell arteritis (GCA) and Takayasu arteritis (TA) are distinct types of large-vessel vasculitis; however, the clinical features of the diseases have some similarities. Limited data are available regarding Japanese patients with GCA and TA. The present study aimed to compare the clinical features and outcomes of Japanese patients with GCA and TA and the effects of large vessel involvement (LVI). Methods: We performed a retrospective cohort study of the patients with GCA (n = 15) and TA (n = 30) who visited our department from April 2012 to June 2022. Signs and symptoms attributed to the disease, treatment, clinical outcomes, and mortality were recorded using a standardized database. Results: The median age of onset was significantly higher in the GCA group at 24 years (range, 16–72 years) in the TA group and 77 years (range, 57–89 years) in the GCA group (p < 0.001). There were no significant differences in survival rates or the cumulative rates of cardiovascular events between the GCA and TA groups. However, relapse-free survival rates were significantly higher in patients with GCA than in patients with TA. Seven of the 15 patients with GCA had large vessel involvement, which did not affect the survival rates. Prednisolone (PSL) doses were significantly decreased after induction therapy in both groups, and the rates of achieving steroid tapering (PSL < 5.0 mg/day) were significantly higher in patients with GCA compared with those in patients with TA. Conclusions: Our study demonstrated no significant difference in the survival rates of Japanese patients with GCA and TA. The relapse-free survival rates were significantly higher in the GCA group than in the TA group. LVI may not be associated with disease relapse or survival rate in Japanese patients with GCA. MDPI 2023-02-22 /pmc/articles/PMC10058730/ /pubmed/36983569 http://dx.doi.org/10.3390/jpm13030387 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yoshida, Shuhei
Suzuki, Eiji
Sumichika, Yuya
Saito, Kenji
Matsumoto, Haruki
Temmoku, Jumpei
Fujita, Yuya
Matsuoka, Naoki
Asano, Tomoyuki
Sato, Shuzo
Watanabe, Hiroshi
Migita, Kiyoshi
Clinical Features and Outcomes of Japanese Patients with Giant Cell Arteritis: A Comparison with Takayasu Arteritis
title Clinical Features and Outcomes of Japanese Patients with Giant Cell Arteritis: A Comparison with Takayasu Arteritis
title_full Clinical Features and Outcomes of Japanese Patients with Giant Cell Arteritis: A Comparison with Takayasu Arteritis
title_fullStr Clinical Features and Outcomes of Japanese Patients with Giant Cell Arteritis: A Comparison with Takayasu Arteritis
title_full_unstemmed Clinical Features and Outcomes of Japanese Patients with Giant Cell Arteritis: A Comparison with Takayasu Arteritis
title_short Clinical Features and Outcomes of Japanese Patients with Giant Cell Arteritis: A Comparison with Takayasu Arteritis
title_sort clinical features and outcomes of japanese patients with giant cell arteritis: a comparison with takayasu arteritis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058730/
https://www.ncbi.nlm.nih.gov/pubmed/36983569
http://dx.doi.org/10.3390/jpm13030387
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