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Enhanced Tensile Properties, Biostability, and Biocompatibility of Siloxane–Cross-Linked Polyurethane Containing Ordered Hard Segments for Durable Implant Application

This work developed a series of siloxane-modified polyurethane (PU–Si) containing ordered hard segments by a facile method. The polyaddition between poly(ε-caprolactone) and excess diurethane diisocyanate was carried out to synthesize a polyurethane prepolymer with terminal isocyanate groups, which...

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Autores principales: Wu, Xiaofei, Jia, Hanxiao, Fu, Wenshuo, Li, Meng, Pan, Yitong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058772/
https://www.ncbi.nlm.nih.gov/pubmed/36985436
http://dx.doi.org/10.3390/molecules28062464
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author Wu, Xiaofei
Jia, Hanxiao
Fu, Wenshuo
Li, Meng
Pan, Yitong
author_facet Wu, Xiaofei
Jia, Hanxiao
Fu, Wenshuo
Li, Meng
Pan, Yitong
author_sort Wu, Xiaofei
collection PubMed
description This work developed a series of siloxane-modified polyurethane (PU–Si) containing ordered hard segments by a facile method. The polyaddition between poly(ε-caprolactone) and excess diurethane diisocyanate was carried out to synthesize a polyurethane prepolymer with terminal isocyanate groups, which was then end-capped by 3-aminopropyl triethoxysilane to produce alkoxysilane-terminated polyurethane; the target products of PU–Si were obtained with hydrolysis and the condensation of alkoxysilane groups. The chemical structures were confirmed by FT-IR and XPS, and the effect of the siloxane content or cross-linked degree on the physicochemical properties of the PU–Si films was investigated in detail. The formation of the network structure linked by Si–O–Si bonds and interchain denser hydrogen bonds endowed PU–Si films with fine phase compatibility, low crystallinity, high thermal stability, and excellent tensile properties. Due to the high cross-linked degree and low interfacial energy, the films displayed a high surface water contact angle and low equilibrium water absorption, which resulted in slow hydrolytic degradation rates. Furthermore, the evaluation of protein adsorption and platelet adhesion on the PU–Si film surface presented high resistance to biofouling, indicating superior surface biocompatibility. Consequently, the siloxane–cross-linked polyurethane, which possessed excellent tensile properties, high biostability, and superior biocompatibility, showed great potential to be explored as biomaterials for durable implants.
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spelling pubmed-100587722023-03-30 Enhanced Tensile Properties, Biostability, and Biocompatibility of Siloxane–Cross-Linked Polyurethane Containing Ordered Hard Segments for Durable Implant Application Wu, Xiaofei Jia, Hanxiao Fu, Wenshuo Li, Meng Pan, Yitong Molecules Article This work developed a series of siloxane-modified polyurethane (PU–Si) containing ordered hard segments by a facile method. The polyaddition between poly(ε-caprolactone) and excess diurethane diisocyanate was carried out to synthesize a polyurethane prepolymer with terminal isocyanate groups, which was then end-capped by 3-aminopropyl triethoxysilane to produce alkoxysilane-terminated polyurethane; the target products of PU–Si were obtained with hydrolysis and the condensation of alkoxysilane groups. The chemical structures were confirmed by FT-IR and XPS, and the effect of the siloxane content or cross-linked degree on the physicochemical properties of the PU–Si films was investigated in detail. The formation of the network structure linked by Si–O–Si bonds and interchain denser hydrogen bonds endowed PU–Si films with fine phase compatibility, low crystallinity, high thermal stability, and excellent tensile properties. Due to the high cross-linked degree and low interfacial energy, the films displayed a high surface water contact angle and low equilibrium water absorption, which resulted in slow hydrolytic degradation rates. Furthermore, the evaluation of protein adsorption and platelet adhesion on the PU–Si film surface presented high resistance to biofouling, indicating superior surface biocompatibility. Consequently, the siloxane–cross-linked polyurethane, which possessed excellent tensile properties, high biostability, and superior biocompatibility, showed great potential to be explored as biomaterials for durable implants. MDPI 2023-03-08 /pmc/articles/PMC10058772/ /pubmed/36985436 http://dx.doi.org/10.3390/molecules28062464 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wu, Xiaofei
Jia, Hanxiao
Fu, Wenshuo
Li, Meng
Pan, Yitong
Enhanced Tensile Properties, Biostability, and Biocompatibility of Siloxane–Cross-Linked Polyurethane Containing Ordered Hard Segments for Durable Implant Application
title Enhanced Tensile Properties, Biostability, and Biocompatibility of Siloxane–Cross-Linked Polyurethane Containing Ordered Hard Segments for Durable Implant Application
title_full Enhanced Tensile Properties, Biostability, and Biocompatibility of Siloxane–Cross-Linked Polyurethane Containing Ordered Hard Segments for Durable Implant Application
title_fullStr Enhanced Tensile Properties, Biostability, and Biocompatibility of Siloxane–Cross-Linked Polyurethane Containing Ordered Hard Segments for Durable Implant Application
title_full_unstemmed Enhanced Tensile Properties, Biostability, and Biocompatibility of Siloxane–Cross-Linked Polyurethane Containing Ordered Hard Segments for Durable Implant Application
title_short Enhanced Tensile Properties, Biostability, and Biocompatibility of Siloxane–Cross-Linked Polyurethane Containing Ordered Hard Segments for Durable Implant Application
title_sort enhanced tensile properties, biostability, and biocompatibility of siloxane–cross-linked polyurethane containing ordered hard segments for durable implant application
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058772/
https://www.ncbi.nlm.nih.gov/pubmed/36985436
http://dx.doi.org/10.3390/molecules28062464
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