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Effective Treatments of UTI—Is Intravesical Therapy the Future?

Urinary tract infection (UTI) afflicts millions of patients globally each year. While the majority of UTIs are successfully treated with orally administered antibiotics, the impact of oral antibiotics on the host microbiota is under close research scrutiny and the potential for dysbiosis is a cause...

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Detalles Bibliográficos
Autores principales: Morris, Chris J., Rohn, Jennifer L., Glickman, Scott, Mansfield, Kylie J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058863/
https://www.ncbi.nlm.nih.gov/pubmed/36986339
http://dx.doi.org/10.3390/pathogens12030417
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author Morris, Chris J.
Rohn, Jennifer L.
Glickman, Scott
Mansfield, Kylie J.
author_facet Morris, Chris J.
Rohn, Jennifer L.
Glickman, Scott
Mansfield, Kylie J.
author_sort Morris, Chris J.
collection PubMed
description Urinary tract infection (UTI) afflicts millions of patients globally each year. While the majority of UTIs are successfully treated with orally administered antibiotics, the impact of oral antibiotics on the host microbiota is under close research scrutiny and the potential for dysbiosis is a cause for concern. Optimal treatment of UTI relies upon the selection of an agent which displays appropriate pharmacokinetic-pharmacodynamic (PK-PD) properties that will deliver appropriately high concentrations in the urinary tract after oral administration. Alternatively, high local concentrations of antibiotic at the urothelial surface can be achieved by direct instillation into the urinary tract. For antibiotics with the appropriate physicochemical properties, this can be of critical importance in cases for which an intracellular urothelial bacterial reservoir is suspected. In this review, we summarise the underpinning biopharmaceutical barriers to effective treatment of UTI and provide an overview of the evidence for the deployment of the intravesical administration route for antibiotics.
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spelling pubmed-100588632023-03-30 Effective Treatments of UTI—Is Intravesical Therapy the Future? Morris, Chris J. Rohn, Jennifer L. Glickman, Scott Mansfield, Kylie J. Pathogens Review Urinary tract infection (UTI) afflicts millions of patients globally each year. While the majority of UTIs are successfully treated with orally administered antibiotics, the impact of oral antibiotics on the host microbiota is under close research scrutiny and the potential for dysbiosis is a cause for concern. Optimal treatment of UTI relies upon the selection of an agent which displays appropriate pharmacokinetic-pharmacodynamic (PK-PD) properties that will deliver appropriately high concentrations in the urinary tract after oral administration. Alternatively, high local concentrations of antibiotic at the urothelial surface can be achieved by direct instillation into the urinary tract. For antibiotics with the appropriate physicochemical properties, this can be of critical importance in cases for which an intracellular urothelial bacterial reservoir is suspected. In this review, we summarise the underpinning biopharmaceutical barriers to effective treatment of UTI and provide an overview of the evidence for the deployment of the intravesical administration route for antibiotics. MDPI 2023-03-06 /pmc/articles/PMC10058863/ /pubmed/36986339 http://dx.doi.org/10.3390/pathogens12030417 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Morris, Chris J.
Rohn, Jennifer L.
Glickman, Scott
Mansfield, Kylie J.
Effective Treatments of UTI—Is Intravesical Therapy the Future?
title Effective Treatments of UTI—Is Intravesical Therapy the Future?
title_full Effective Treatments of UTI—Is Intravesical Therapy the Future?
title_fullStr Effective Treatments of UTI—Is Intravesical Therapy the Future?
title_full_unstemmed Effective Treatments of UTI—Is Intravesical Therapy the Future?
title_short Effective Treatments of UTI—Is Intravesical Therapy the Future?
title_sort effective treatments of uti—is intravesical therapy the future?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058863/
https://www.ncbi.nlm.nih.gov/pubmed/36986339
http://dx.doi.org/10.3390/pathogens12030417
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