Cargando…

Myricetin Nanofibers Enhanced Water Solubility and Skin Penetration for Increasing Antioxidant and Photoprotective Activities

Excessive exposure to ultraviolet radiation (UV) can induce oxidative stress through the over-production of reactive oxygen species (ROS) on the skin. Myricetin (MYR), a natural flavonoid compound, significantly inhibited UV-induced keratinocyte damage; however, its bioavailability is limited by its...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Tzu-Ching, Yang, Chun-Yin, Wu, Tzu-Hui, Tseng, Chih-Hua, Yen, Feng-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058934/
https://www.ncbi.nlm.nih.gov/pubmed/36986766
http://dx.doi.org/10.3390/pharmaceutics15030906
_version_ 1785016754272993280
author Lin, Tzu-Ching
Yang, Chun-Yin
Wu, Tzu-Hui
Tseng, Chih-Hua
Yen, Feng-Lin
author_facet Lin, Tzu-Ching
Yang, Chun-Yin
Wu, Tzu-Hui
Tseng, Chih-Hua
Yen, Feng-Lin
author_sort Lin, Tzu-Ching
collection PubMed
description Excessive exposure to ultraviolet radiation (UV) can induce oxidative stress through the over-production of reactive oxygen species (ROS) on the skin. Myricetin (MYR), a natural flavonoid compound, significantly inhibited UV-induced keratinocyte damage; however, its bioavailability is limited by its poor water solubility and inefficient skin penetration ability, which subsequently influences its biological activity. The purpose of the study was to develop a myricetin nanofibers (MyNF) system of hydroxypropyl-β-cyclodextrin (HPBCD)/polyvinylpyrrolidone K120 (PVP)-loaded with MYR that would enhance the water solubility and skin penetration by changing the physicochemical characteristics of MYR, including reducing the particle size, increasing the specific surface area, and amorphous transformation. The results also revealed that the MyNF can reduce cytotoxicity in HaCaT keratinocytes when compared with MYR; additionally, MyNF had better antioxidant and photoprotective activity than raw MYR for the UVB-induced HaCaT keratinocytes damage model due to the MyNF increased water solubility and permeability. In conclusion, our results demonstrate that MyNF is a safe, photostable, and thermostable topical ingredient of antioxidant nanofibers to enhance the skin penetration of MYR and prevent UVB-induced skin damage.
format Online
Article
Text
id pubmed-10058934
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100589342023-03-30 Myricetin Nanofibers Enhanced Water Solubility and Skin Penetration for Increasing Antioxidant and Photoprotective Activities Lin, Tzu-Ching Yang, Chun-Yin Wu, Tzu-Hui Tseng, Chih-Hua Yen, Feng-Lin Pharmaceutics Article Excessive exposure to ultraviolet radiation (UV) can induce oxidative stress through the over-production of reactive oxygen species (ROS) on the skin. Myricetin (MYR), a natural flavonoid compound, significantly inhibited UV-induced keratinocyte damage; however, its bioavailability is limited by its poor water solubility and inefficient skin penetration ability, which subsequently influences its biological activity. The purpose of the study was to develop a myricetin nanofibers (MyNF) system of hydroxypropyl-β-cyclodextrin (HPBCD)/polyvinylpyrrolidone K120 (PVP)-loaded with MYR that would enhance the water solubility and skin penetration by changing the physicochemical characteristics of MYR, including reducing the particle size, increasing the specific surface area, and amorphous transformation. The results also revealed that the MyNF can reduce cytotoxicity in HaCaT keratinocytes when compared with MYR; additionally, MyNF had better antioxidant and photoprotective activity than raw MYR for the UVB-induced HaCaT keratinocytes damage model due to the MyNF increased water solubility and permeability. In conclusion, our results demonstrate that MyNF is a safe, photostable, and thermostable topical ingredient of antioxidant nanofibers to enhance the skin penetration of MYR and prevent UVB-induced skin damage. MDPI 2023-03-10 /pmc/articles/PMC10058934/ /pubmed/36986766 http://dx.doi.org/10.3390/pharmaceutics15030906 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lin, Tzu-Ching
Yang, Chun-Yin
Wu, Tzu-Hui
Tseng, Chih-Hua
Yen, Feng-Lin
Myricetin Nanofibers Enhanced Water Solubility and Skin Penetration for Increasing Antioxidant and Photoprotective Activities
title Myricetin Nanofibers Enhanced Water Solubility and Skin Penetration for Increasing Antioxidant and Photoprotective Activities
title_full Myricetin Nanofibers Enhanced Water Solubility and Skin Penetration for Increasing Antioxidant and Photoprotective Activities
title_fullStr Myricetin Nanofibers Enhanced Water Solubility and Skin Penetration for Increasing Antioxidant and Photoprotective Activities
title_full_unstemmed Myricetin Nanofibers Enhanced Water Solubility and Skin Penetration for Increasing Antioxidant and Photoprotective Activities
title_short Myricetin Nanofibers Enhanced Water Solubility and Skin Penetration for Increasing Antioxidant and Photoprotective Activities
title_sort myricetin nanofibers enhanced water solubility and skin penetration for increasing antioxidant and photoprotective activities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058934/
https://www.ncbi.nlm.nih.gov/pubmed/36986766
http://dx.doi.org/10.3390/pharmaceutics15030906
work_keys_str_mv AT lintzuching myricetinnanofibersenhancedwatersolubilityandskinpenetrationforincreasingantioxidantandphotoprotectiveactivities
AT yangchunyin myricetinnanofibersenhancedwatersolubilityandskinpenetrationforincreasingantioxidantandphotoprotectiveactivities
AT wutzuhui myricetinnanofibersenhancedwatersolubilityandskinpenetrationforincreasingantioxidantandphotoprotectiveactivities
AT tsengchihhua myricetinnanofibersenhancedwatersolubilityandskinpenetrationforincreasingantioxidantandphotoprotectiveactivities
AT yenfenglin myricetinnanofibersenhancedwatersolubilityandskinpenetrationforincreasingantioxidantandphotoprotectiveactivities