Cargando…

Mucormycosis in a Patient with Severe COVID-19 Disease—The First Case Report in Romania and a Literature Review

Introduction: COVID-19 infection is often associated with a vast spectrum of opportunistic bacterial and fungal infections. Herein, we share a summary of the first case of COVID-19-associated mucormycosis (CAM) in a patient from Romania. Case presentation: A 51-year-old male non-smoker, with no know...

Descripción completa

Detalles Bibliográficos
Autores principales: Mahler, Beatrice, Parliteanu, Oana Andreea, Alexe, Octavian, Rîșcă Popazu, Corina, Ene, Catalina Elena, Timar, Bogdan, Constantinescu, Tudor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058997/
https://www.ncbi.nlm.nih.gov/pubmed/36984555
http://dx.doi.org/10.3390/medicina59030555
_version_ 1785016769482588160
author Mahler, Beatrice
Parliteanu, Oana Andreea
Alexe, Octavian
Rîșcă Popazu, Corina
Ene, Catalina Elena
Timar, Bogdan
Constantinescu, Tudor
author_facet Mahler, Beatrice
Parliteanu, Oana Andreea
Alexe, Octavian
Rîșcă Popazu, Corina
Ene, Catalina Elena
Timar, Bogdan
Constantinescu, Tudor
author_sort Mahler, Beatrice
collection PubMed
description Introduction: COVID-19 infection is often associated with a vast spectrum of opportunistic bacterial and fungal infections. Herein, we share a summary of the first case of COVID-19-associated mucormycosis (CAM) in a patient from Romania. Case presentation: A 51-year-old male non-smoker, with no known relevant medical history, who denied any previous alcohol use and was vaccinated against COVID-19 (complete scheme with Vaxzevria), was admitted to the hospital for severe COVID-19 infection. The first mucormycosis-related symptoms were reported on the eighth day of admission and were followed by the rapid deterioration of the patient’s condition and, consequently, death. The main aggravating factors, which were identified to be associated with the development of mucormycosis and with the poor outcome, were the association of severe COVID-19, new-onset COVID-19-triggered type 2 diabetes, and corticoid treatment for severe COVID-19. Conclusion: The association between severe COVID-19 and newly diagnosed type 2 diabetes, triggered by COVID-19 infection, increases the risk of severe opportunistic fungal infections and the associated mortality rates.
format Online
Article
Text
id pubmed-10058997
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100589972023-03-30 Mucormycosis in a Patient with Severe COVID-19 Disease—The First Case Report in Romania and a Literature Review Mahler, Beatrice Parliteanu, Oana Andreea Alexe, Octavian Rîșcă Popazu, Corina Ene, Catalina Elena Timar, Bogdan Constantinescu, Tudor Medicina (Kaunas) Case Report Introduction: COVID-19 infection is often associated with a vast spectrum of opportunistic bacterial and fungal infections. Herein, we share a summary of the first case of COVID-19-associated mucormycosis (CAM) in a patient from Romania. Case presentation: A 51-year-old male non-smoker, with no known relevant medical history, who denied any previous alcohol use and was vaccinated against COVID-19 (complete scheme with Vaxzevria), was admitted to the hospital for severe COVID-19 infection. The first mucormycosis-related symptoms were reported on the eighth day of admission and were followed by the rapid deterioration of the patient’s condition and, consequently, death. The main aggravating factors, which were identified to be associated with the development of mucormycosis and with the poor outcome, were the association of severe COVID-19, new-onset COVID-19-triggered type 2 diabetes, and corticoid treatment for severe COVID-19. Conclusion: The association between severe COVID-19 and newly diagnosed type 2 diabetes, triggered by COVID-19 infection, increases the risk of severe opportunistic fungal infections and the associated mortality rates. MDPI 2023-03-11 /pmc/articles/PMC10058997/ /pubmed/36984555 http://dx.doi.org/10.3390/medicina59030555 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Mahler, Beatrice
Parliteanu, Oana Andreea
Alexe, Octavian
Rîșcă Popazu, Corina
Ene, Catalina Elena
Timar, Bogdan
Constantinescu, Tudor
Mucormycosis in a Patient with Severe COVID-19 Disease—The First Case Report in Romania and a Literature Review
title Mucormycosis in a Patient with Severe COVID-19 Disease—The First Case Report in Romania and a Literature Review
title_full Mucormycosis in a Patient with Severe COVID-19 Disease—The First Case Report in Romania and a Literature Review
title_fullStr Mucormycosis in a Patient with Severe COVID-19 Disease—The First Case Report in Romania and a Literature Review
title_full_unstemmed Mucormycosis in a Patient with Severe COVID-19 Disease—The First Case Report in Romania and a Literature Review
title_short Mucormycosis in a Patient with Severe COVID-19 Disease—The First Case Report in Romania and a Literature Review
title_sort mucormycosis in a patient with severe covid-19 disease—the first case report in romania and a literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058997/
https://www.ncbi.nlm.nih.gov/pubmed/36984555
http://dx.doi.org/10.3390/medicina59030555
work_keys_str_mv AT mahlerbeatrice mucormycosisinapatientwithseverecovid19diseasethefirstcasereportinromaniaandaliteraturereview
AT parliteanuoanaandreea mucormycosisinapatientwithseverecovid19diseasethefirstcasereportinromaniaandaliteraturereview
AT alexeoctavian mucormycosisinapatientwithseverecovid19diseasethefirstcasereportinromaniaandaliteraturereview
AT riscapopazucorina mucormycosisinapatientwithseverecovid19diseasethefirstcasereportinromaniaandaliteraturereview
AT enecatalinaelena mucormycosisinapatientwithseverecovid19diseasethefirstcasereportinromaniaandaliteraturereview
AT timarbogdan mucormycosisinapatientwithseverecovid19diseasethefirstcasereportinromaniaandaliteraturereview
AT constantinescutudor mucormycosisinapatientwithseverecovid19diseasethefirstcasereportinromaniaandaliteraturereview