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Comparative Gut Microbiome Differences between High and Low Aortic Arch Calcification Score in Patients with Chronic Diseases

Gut dysbiosis can induce chronic inflammation and contribute to atherosclerosis and vascular calcification. The aortic arch calcification (AoAC) score is a simple, noninvasive, and semiquantitative assessment tool to evaluate vascular calcification on chest radiographs. Few studies have discussed th...

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Autores principales: Liu, Yi-Hsueh, Peng, Po, Hung, Wei-Chun, Wu, Ping-Hsun, Kao, Cheng-Yuan, Wu, Pei-Yu, Huang, Jiun-Chi, Hung, Chih-Hsing, Su, Ho-Ming, Chen, Szu-Chia, Kuo, Chao-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10059004/
https://www.ncbi.nlm.nih.gov/pubmed/36982746
http://dx.doi.org/10.3390/ijms24065673
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author Liu, Yi-Hsueh
Peng, Po
Hung, Wei-Chun
Wu, Ping-Hsun
Kao, Cheng-Yuan
Wu, Pei-Yu
Huang, Jiun-Chi
Hung, Chih-Hsing
Su, Ho-Ming
Chen, Szu-Chia
Kuo, Chao-Hung
author_facet Liu, Yi-Hsueh
Peng, Po
Hung, Wei-Chun
Wu, Ping-Hsun
Kao, Cheng-Yuan
Wu, Pei-Yu
Huang, Jiun-Chi
Hung, Chih-Hsing
Su, Ho-Ming
Chen, Szu-Chia
Kuo, Chao-Hung
author_sort Liu, Yi-Hsueh
collection PubMed
description Gut dysbiosis can induce chronic inflammation and contribute to atherosclerosis and vascular calcification. The aortic arch calcification (AoAC) score is a simple, noninvasive, and semiquantitative assessment tool to evaluate vascular calcification on chest radiographs. Few studies have discussed the relationship between gut microbiota and AoAC. Therefore, this study aimed to compare the microbiota composition between patients with chronic diseases and high or low AoAC scores. A total of 186 patients (118 males and 68 females) with chronic diseases, including diabetes mellitus (80.6%), hypertension (75.3%), and chronic kidney disease (48.9%), were enrolled. Gut microbiota in fecal samples were analyzed by sequencing of the 16S rRNA gene, and differences in microbial function were examined. The patients were divided into three groups according to AoAC score, including 103 patients in the low AoAC group (AoAC ≤ 3), 40 patients in the medium AoAC group (3 < AoAC ≤ 6), and 43 patients in the high AoAC group (AoAC > 6). Compared to the low AoAC group, the high AoAC group had a significantly lower microbial species diversity (Chao1 index and Shannon index) and increased microbial dysbiosis index. Beta diversity showed that the microbial community composition was significantly different among the three groups (p = 0.041, weighted UniFrac PCoA). A distinct microbial community structure was found in the patients with a low AoAC, with an increased abundance at the genus level of Agathobacter, Eubacterium coprostanoligenes group, Ruminococcaceae UCG-002, Barnesiella, Butyricimonas, Oscillibacter, Ruminococcaceae DTU089, and Oxalobacter. In addition, there was an increased relative abundance of class Bacilli in the high AoAC group. Our findings support the association between gut dysbiosis and the severity of AoAC in patients with chronic diseases.
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spelling pubmed-100590042023-03-30 Comparative Gut Microbiome Differences between High and Low Aortic Arch Calcification Score in Patients with Chronic Diseases Liu, Yi-Hsueh Peng, Po Hung, Wei-Chun Wu, Ping-Hsun Kao, Cheng-Yuan Wu, Pei-Yu Huang, Jiun-Chi Hung, Chih-Hsing Su, Ho-Ming Chen, Szu-Chia Kuo, Chao-Hung Int J Mol Sci Article Gut dysbiosis can induce chronic inflammation and contribute to atherosclerosis and vascular calcification. The aortic arch calcification (AoAC) score is a simple, noninvasive, and semiquantitative assessment tool to evaluate vascular calcification on chest radiographs. Few studies have discussed the relationship between gut microbiota and AoAC. Therefore, this study aimed to compare the microbiota composition between patients with chronic diseases and high or low AoAC scores. A total of 186 patients (118 males and 68 females) with chronic diseases, including diabetes mellitus (80.6%), hypertension (75.3%), and chronic kidney disease (48.9%), were enrolled. Gut microbiota in fecal samples were analyzed by sequencing of the 16S rRNA gene, and differences in microbial function were examined. The patients were divided into three groups according to AoAC score, including 103 patients in the low AoAC group (AoAC ≤ 3), 40 patients in the medium AoAC group (3 < AoAC ≤ 6), and 43 patients in the high AoAC group (AoAC > 6). Compared to the low AoAC group, the high AoAC group had a significantly lower microbial species diversity (Chao1 index and Shannon index) and increased microbial dysbiosis index. Beta diversity showed that the microbial community composition was significantly different among the three groups (p = 0.041, weighted UniFrac PCoA). A distinct microbial community structure was found in the patients with a low AoAC, with an increased abundance at the genus level of Agathobacter, Eubacterium coprostanoligenes group, Ruminococcaceae UCG-002, Barnesiella, Butyricimonas, Oscillibacter, Ruminococcaceae DTU089, and Oxalobacter. In addition, there was an increased relative abundance of class Bacilli in the high AoAC group. Our findings support the association between gut dysbiosis and the severity of AoAC in patients with chronic diseases. MDPI 2023-03-16 /pmc/articles/PMC10059004/ /pubmed/36982746 http://dx.doi.org/10.3390/ijms24065673 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Yi-Hsueh
Peng, Po
Hung, Wei-Chun
Wu, Ping-Hsun
Kao, Cheng-Yuan
Wu, Pei-Yu
Huang, Jiun-Chi
Hung, Chih-Hsing
Su, Ho-Ming
Chen, Szu-Chia
Kuo, Chao-Hung
Comparative Gut Microbiome Differences between High and Low Aortic Arch Calcification Score in Patients with Chronic Diseases
title Comparative Gut Microbiome Differences between High and Low Aortic Arch Calcification Score in Patients with Chronic Diseases
title_full Comparative Gut Microbiome Differences between High and Low Aortic Arch Calcification Score in Patients with Chronic Diseases
title_fullStr Comparative Gut Microbiome Differences between High and Low Aortic Arch Calcification Score in Patients with Chronic Diseases
title_full_unstemmed Comparative Gut Microbiome Differences between High and Low Aortic Arch Calcification Score in Patients with Chronic Diseases
title_short Comparative Gut Microbiome Differences between High and Low Aortic Arch Calcification Score in Patients with Chronic Diseases
title_sort comparative gut microbiome differences between high and low aortic arch calcification score in patients with chronic diseases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10059004/
https://www.ncbi.nlm.nih.gov/pubmed/36982746
http://dx.doi.org/10.3390/ijms24065673
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