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Vascular Progenitor Cells: From Cancer to Tissue Repair

Vascular progenitor cells are activated to repair and form a neointima following vascular damage such as hypertension, atherosclerosis, diabetes, trauma, hypoxia, primary cancerous lesions and metastases as well as catheter interventions. They play a key role not only in the resolution of the vascul...

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Detalles Bibliográficos
Autores principales: Barachini, Serena, Ghelardoni, Sandra, Madonna, Rosalinda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10059009/
https://www.ncbi.nlm.nih.gov/pubmed/36983398
http://dx.doi.org/10.3390/jcm12062399
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author Barachini, Serena
Ghelardoni, Sandra
Madonna, Rosalinda
author_facet Barachini, Serena
Ghelardoni, Sandra
Madonna, Rosalinda
author_sort Barachini, Serena
collection PubMed
description Vascular progenitor cells are activated to repair and form a neointima following vascular damage such as hypertension, atherosclerosis, diabetes, trauma, hypoxia, primary cancerous lesions and metastases as well as catheter interventions. They play a key role not only in the resolution of the vascular lesion but also in the adult neovascularization and angiogenesis sprouting (i.e., the growth of new capillaries from pre-existing ones), often associated with carcinogenesis, favoring the formation of metastases, survival and progression of tumors. In this review, we discuss the biology, cellular plasticity and pathophysiology of different vascular progenitor cells, including their origins (sources), stimuli and activated pathways that induce differentiation, isolation and characterization. We focus on their role in tumor-induced vascular injury and discuss their implications in promoting tumor angiogenesis during cancer proliferation and migration.
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spelling pubmed-100590092023-03-30 Vascular Progenitor Cells: From Cancer to Tissue Repair Barachini, Serena Ghelardoni, Sandra Madonna, Rosalinda J Clin Med Review Vascular progenitor cells are activated to repair and form a neointima following vascular damage such as hypertension, atherosclerosis, diabetes, trauma, hypoxia, primary cancerous lesions and metastases as well as catheter interventions. They play a key role not only in the resolution of the vascular lesion but also in the adult neovascularization and angiogenesis sprouting (i.e., the growth of new capillaries from pre-existing ones), often associated with carcinogenesis, favoring the formation of metastases, survival and progression of tumors. In this review, we discuss the biology, cellular plasticity and pathophysiology of different vascular progenitor cells, including their origins (sources), stimuli and activated pathways that induce differentiation, isolation and characterization. We focus on their role in tumor-induced vascular injury and discuss their implications in promoting tumor angiogenesis during cancer proliferation and migration. MDPI 2023-03-20 /pmc/articles/PMC10059009/ /pubmed/36983398 http://dx.doi.org/10.3390/jcm12062399 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Barachini, Serena
Ghelardoni, Sandra
Madonna, Rosalinda
Vascular Progenitor Cells: From Cancer to Tissue Repair
title Vascular Progenitor Cells: From Cancer to Tissue Repair
title_full Vascular Progenitor Cells: From Cancer to Tissue Repair
title_fullStr Vascular Progenitor Cells: From Cancer to Tissue Repair
title_full_unstemmed Vascular Progenitor Cells: From Cancer to Tissue Repair
title_short Vascular Progenitor Cells: From Cancer to Tissue Repair
title_sort vascular progenitor cells: from cancer to tissue repair
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10059009/
https://www.ncbi.nlm.nih.gov/pubmed/36983398
http://dx.doi.org/10.3390/jcm12062399
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