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Antileishmanial and Antiplasmodial Activities of Secondary Metabolites from the Root of Antrocaryon klaineanum Pierre (Anacardiaceae)
Antrocaryon klaineanum is traditionally used for the treatment of back pain, malaria, female sterility, chlamydiae infections, liver diseases, wounds, and hemorrhoid. This work aimed at investigating the bioactive compounds with antileishmanial and antiplasmodial activities from A. klaineanum. An un...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10059057/ https://www.ncbi.nlm.nih.gov/pubmed/36985700 http://dx.doi.org/10.3390/molecules28062730 |
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author | Amang à Ngnoung, Gabrielle Ange Sidjui, Lazare S. Leutcha, Peron B. Nganso Ditchou, Yves O. Tchokouaha, Lauve R. Y. Herbette, Gaëtan Baghdikian, Beatrice Kowa, Theodora K. Soh, Desire Kemzeu, Raoul Poka, Madan Demana, Patrick H. Siwe Noundou, Xavier Tchinda, Alembert T. Fekam Boyom, Fabrice Lannang, Alain M. Nyassé, Barthélemy |
author_facet | Amang à Ngnoung, Gabrielle Ange Sidjui, Lazare S. Leutcha, Peron B. Nganso Ditchou, Yves O. Tchokouaha, Lauve R. Y. Herbette, Gaëtan Baghdikian, Beatrice Kowa, Theodora K. Soh, Desire Kemzeu, Raoul Poka, Madan Demana, Patrick H. Siwe Noundou, Xavier Tchinda, Alembert T. Fekam Boyom, Fabrice Lannang, Alain M. Nyassé, Barthélemy |
author_sort | Amang à Ngnoung, Gabrielle Ange |
collection | PubMed |
description | Antrocaryon klaineanum is traditionally used for the treatment of back pain, malaria, female sterility, chlamydiae infections, liver diseases, wounds, and hemorrhoid. This work aimed at investigating the bioactive compounds with antileishmanial and antiplasmodial activities from A. klaineanum. An unreported glucocerebroside antroklaicerebroside (1) together with five known compounds (2–6) were isolated from the root barks of Antrocaryon klaineanum using chromatographic techniques. The NMR, MS, and IR spectroscopic data in association with previous literature were used for the characterization of all the isolated compounds. Compounds 1–4 are reported for the first time from A. klaineanum. The methanol crude extract (AK-MeOH), the n-hexane fraction (AK-Hex), the dichloromethane fraction (AK-DCM), the ethyl acetate fraction (AK-EtOAc), and compounds 1–6 were all evaluated for their antiparasitic effects against Plasmodium falciparum strains susceptible to chloroquine (3D7), resistant to chloroquine (Dd2), and promastigotes of Leishmania donovani (MHOM/SD/62/1S). The AK-Hex, AK-EtOAc, AK-MeOH, and compound 2 were strongly active against Dd2 strain with IC(50) ranging from 2.78 ± 0.06 to 9.30 ± 0.29 µg/mL. Particularly, AK-MeOH was the most active—more than the reference drugs used—with an IC(50) of 2.78 ± 0.06 µg/mL. The AK-EtOAc as well as all the tested compounds showed strong antileishmanial activities with IC(50) ranging from 4.80 ± 0.13 to 9.14 ± 0.96 µg/mL. |
format | Online Article Text |
id | pubmed-10059057 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100590572023-03-30 Antileishmanial and Antiplasmodial Activities of Secondary Metabolites from the Root of Antrocaryon klaineanum Pierre (Anacardiaceae) Amang à Ngnoung, Gabrielle Ange Sidjui, Lazare S. Leutcha, Peron B. Nganso Ditchou, Yves O. Tchokouaha, Lauve R. Y. Herbette, Gaëtan Baghdikian, Beatrice Kowa, Theodora K. Soh, Desire Kemzeu, Raoul Poka, Madan Demana, Patrick H. Siwe Noundou, Xavier Tchinda, Alembert T. Fekam Boyom, Fabrice Lannang, Alain M. Nyassé, Barthélemy Molecules Article Antrocaryon klaineanum is traditionally used for the treatment of back pain, malaria, female sterility, chlamydiae infections, liver diseases, wounds, and hemorrhoid. This work aimed at investigating the bioactive compounds with antileishmanial and antiplasmodial activities from A. klaineanum. An unreported glucocerebroside antroklaicerebroside (1) together with five known compounds (2–6) were isolated from the root barks of Antrocaryon klaineanum using chromatographic techniques. The NMR, MS, and IR spectroscopic data in association with previous literature were used for the characterization of all the isolated compounds. Compounds 1–4 are reported for the first time from A. klaineanum. The methanol crude extract (AK-MeOH), the n-hexane fraction (AK-Hex), the dichloromethane fraction (AK-DCM), the ethyl acetate fraction (AK-EtOAc), and compounds 1–6 were all evaluated for their antiparasitic effects against Plasmodium falciparum strains susceptible to chloroquine (3D7), resistant to chloroquine (Dd2), and promastigotes of Leishmania donovani (MHOM/SD/62/1S). The AK-Hex, AK-EtOAc, AK-MeOH, and compound 2 were strongly active against Dd2 strain with IC(50) ranging from 2.78 ± 0.06 to 9.30 ± 0.29 µg/mL. Particularly, AK-MeOH was the most active—more than the reference drugs used—with an IC(50) of 2.78 ± 0.06 µg/mL. The AK-EtOAc as well as all the tested compounds showed strong antileishmanial activities with IC(50) ranging from 4.80 ± 0.13 to 9.14 ± 0.96 µg/mL. MDPI 2023-03-17 /pmc/articles/PMC10059057/ /pubmed/36985700 http://dx.doi.org/10.3390/molecules28062730 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Amang à Ngnoung, Gabrielle Ange Sidjui, Lazare S. Leutcha, Peron B. Nganso Ditchou, Yves O. Tchokouaha, Lauve R. Y. Herbette, Gaëtan Baghdikian, Beatrice Kowa, Theodora K. Soh, Desire Kemzeu, Raoul Poka, Madan Demana, Patrick H. Siwe Noundou, Xavier Tchinda, Alembert T. Fekam Boyom, Fabrice Lannang, Alain M. Nyassé, Barthélemy Antileishmanial and Antiplasmodial Activities of Secondary Metabolites from the Root of Antrocaryon klaineanum Pierre (Anacardiaceae) |
title | Antileishmanial and Antiplasmodial Activities of Secondary Metabolites from the Root of Antrocaryon klaineanum Pierre (Anacardiaceae) |
title_full | Antileishmanial and Antiplasmodial Activities of Secondary Metabolites from the Root of Antrocaryon klaineanum Pierre (Anacardiaceae) |
title_fullStr | Antileishmanial and Antiplasmodial Activities of Secondary Metabolites from the Root of Antrocaryon klaineanum Pierre (Anacardiaceae) |
title_full_unstemmed | Antileishmanial and Antiplasmodial Activities of Secondary Metabolites from the Root of Antrocaryon klaineanum Pierre (Anacardiaceae) |
title_short | Antileishmanial and Antiplasmodial Activities of Secondary Metabolites from the Root of Antrocaryon klaineanum Pierre (Anacardiaceae) |
title_sort | antileishmanial and antiplasmodial activities of secondary metabolites from the root of antrocaryon klaineanum pierre (anacardiaceae) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10059057/ https://www.ncbi.nlm.nih.gov/pubmed/36985700 http://dx.doi.org/10.3390/molecules28062730 |
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