On the Need for Human Studies of PM Exposure Activation of the NLRP3 Inflammasome

Particulate matter air pollution is associated with blood inflammatory biomarkers, however, the biological pathways from exposure to periferal inflammation are not well understood. We propose that the NLRP3 inflammasome is likely stimulated by ambient particulate matter, as it is by some other parti...

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Detalles Bibliográficos
Autores principales: Brugge, Doug, Li, Jianghong, Zamore, Wig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10059209/
https://www.ncbi.nlm.nih.gov/pubmed/36976967
http://dx.doi.org/10.3390/toxics11030202
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author Brugge, Doug
Li, Jianghong
Zamore, Wig
author_facet Brugge, Doug
Li, Jianghong
Zamore, Wig
author_sort Brugge, Doug
collection PubMed
description Particulate matter air pollution is associated with blood inflammatory biomarkers, however, the biological pathways from exposure to periferal inflammation are not well understood. We propose that the NLRP3 inflammasome is likely stimulated by ambient particulate matter, as it is by some other particles and call for more research into this pathway.
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spelling pubmed-100592092023-03-30 On the Need for Human Studies of PM Exposure Activation of the NLRP3 Inflammasome Brugge, Doug Li, Jianghong Zamore, Wig Toxics Commentary Particulate matter air pollution is associated with blood inflammatory biomarkers, however, the biological pathways from exposure to periferal inflammation are not well understood. We propose that the NLRP3 inflammasome is likely stimulated by ambient particulate matter, as it is by some other particles and call for more research into this pathway. MDPI 2023-02-21 /pmc/articles/PMC10059209/ /pubmed/36976967 http://dx.doi.org/10.3390/toxics11030202 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Commentary
Brugge, Doug
Li, Jianghong
Zamore, Wig
On the Need for Human Studies of PM Exposure Activation of the NLRP3 Inflammasome
title On the Need for Human Studies of PM Exposure Activation of the NLRP3 Inflammasome
title_full On the Need for Human Studies of PM Exposure Activation of the NLRP3 Inflammasome
title_fullStr On the Need for Human Studies of PM Exposure Activation of the NLRP3 Inflammasome
title_full_unstemmed On the Need for Human Studies of PM Exposure Activation of the NLRP3 Inflammasome
title_short On the Need for Human Studies of PM Exposure Activation of the NLRP3 Inflammasome
title_sort on the need for human studies of pm exposure activation of the nlrp3 inflammasome
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10059209/
https://www.ncbi.nlm.nih.gov/pubmed/36976967
http://dx.doi.org/10.3390/toxics11030202
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