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Multimorbidity of Allergic Conditions in Urban Citizens of Southern China: A Real-World Cross-Sectional Study

Background: Extensive knowledge of allergic multimorbidities is required to improve the management of allergic diseases with the industrialization of China. However, the demography and allergen distribution patterns of allergic multimorbidities in China remain unclear, despite the increasing prevale...

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Autores principales: Li, Ya-Ting, Hou, Ming-Hui, Lu, Ya-Xin, Chen, Pei-Ran, Dai, Zhen-Yuan, Yang, Li-Fen, Zhang, Ping-Ping, Xiong, Guo-Wei, Liu, Zi-Feng, Zhou, Qi-Lin, Su, Jing, Cheng, Yun, Zhou, Yu-Qi, Tao, Jin, Huang, Xue-Kun, Dai, Min, Zhang, Kun, Zhou, Min, Yang, Qin-Tai, Feng, Pei-Ying, Chen, Zhuang-Gui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10059830/
https://www.ncbi.nlm.nih.gov/pubmed/36983228
http://dx.doi.org/10.3390/jcm12062226
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author Li, Ya-Ting
Hou, Ming-Hui
Lu, Ya-Xin
Chen, Pei-Ran
Dai, Zhen-Yuan
Yang, Li-Fen
Zhang, Ping-Ping
Xiong, Guo-Wei
Liu, Zi-Feng
Zhou, Qi-Lin
Su, Jing
Cheng, Yun
Zhou, Yu-Qi
Tao, Jin
Huang, Xue-Kun
Dai, Min
Zhang, Kun
Zhou, Min
Yang, Qin-Tai
Feng, Pei-Ying
Chen, Zhuang-Gui
author_facet Li, Ya-Ting
Hou, Ming-Hui
Lu, Ya-Xin
Chen, Pei-Ran
Dai, Zhen-Yuan
Yang, Li-Fen
Zhang, Ping-Ping
Xiong, Guo-Wei
Liu, Zi-Feng
Zhou, Qi-Lin
Su, Jing
Cheng, Yun
Zhou, Yu-Qi
Tao, Jin
Huang, Xue-Kun
Dai, Min
Zhang, Kun
Zhou, Min
Yang, Qin-Tai
Feng, Pei-Ying
Chen, Zhuang-Gui
author_sort Li, Ya-Ting
collection PubMed
description Background: Extensive knowledge of allergic multimorbidities is required to improve the management of allergic diseases with the industrialization of China. However, the demography and allergen distribution patterns of allergic multimorbidities in China remain unclear, despite the increasing prevalence of allergies. Methods: This was a real-world, cross-sectional study of 1273 outpatients diagnosed with one or more allergic diseases in Guangzhou, the most populated city of southern China, with leading industrial and commercial centers, between April 2021 and March 2022. Seven allergic diseases (allergic rhinitis (AR), asthma (AS)/cough variant asthma (CVA), atopic dermatitis (AD)/eczema, food allergy (FA), allergic conjunctivitis (AC), drug allergy (DA), and anaphylaxis) were assessed. Positive rates of sensitization to different allergens were measured using an allergen detection system of the UniCAP (Pharmacia Diagnostics, Sweden) instrument platform to compare the groups of allergic multimorbidities against a single entity. Results: There were 659 (51.8%) males and 614 (48.2%) females aged from 4 months to 74 years included in the analysis. The study participants who were diagnosed with allergic diseases had an average of 1.6 diagnoses. Overall, 46.5% (592 of 1273) of the patients had more than one allergic condition, and allergic rhinitis was the most common type of multimorbidity. Women were more likely to suffer from an allergic disease alone, whereas allergic multimorbidities were more likely to be diagnosed in men (p = 0.005). In addition, allergic multimorbidities were common in all age groups, with an incidence ranging from 37.1% to 57.4%, in which children and adolescents were more frequently diagnosed with allergic multimorbidities than adults (18–60 years old) (all p < 0.05). Allergic multimorbidity was observed throughout the year. A difference in the positive rate of allergens sensitization and total immunoglobulin E (tIgE) levels between different allergic multimorbidities was observed. Conclusions: Allergic multimorbidities were very commonly found in nearly half of all patients with allergies. The proportion of allergic multimorbidities varied with the type of disease, sex, age, and allergen distribution pattern. These findings may help clinicians to develop “One health” strategies for the clinical management of allergic diseases.
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spelling pubmed-100598302023-03-30 Multimorbidity of Allergic Conditions in Urban Citizens of Southern China: A Real-World Cross-Sectional Study Li, Ya-Ting Hou, Ming-Hui Lu, Ya-Xin Chen, Pei-Ran Dai, Zhen-Yuan Yang, Li-Fen Zhang, Ping-Ping Xiong, Guo-Wei Liu, Zi-Feng Zhou, Qi-Lin Su, Jing Cheng, Yun Zhou, Yu-Qi Tao, Jin Huang, Xue-Kun Dai, Min Zhang, Kun Zhou, Min Yang, Qin-Tai Feng, Pei-Ying Chen, Zhuang-Gui J Clin Med Article Background: Extensive knowledge of allergic multimorbidities is required to improve the management of allergic diseases with the industrialization of China. However, the demography and allergen distribution patterns of allergic multimorbidities in China remain unclear, despite the increasing prevalence of allergies. Methods: This was a real-world, cross-sectional study of 1273 outpatients diagnosed with one or more allergic diseases in Guangzhou, the most populated city of southern China, with leading industrial and commercial centers, between April 2021 and March 2022. Seven allergic diseases (allergic rhinitis (AR), asthma (AS)/cough variant asthma (CVA), atopic dermatitis (AD)/eczema, food allergy (FA), allergic conjunctivitis (AC), drug allergy (DA), and anaphylaxis) were assessed. Positive rates of sensitization to different allergens were measured using an allergen detection system of the UniCAP (Pharmacia Diagnostics, Sweden) instrument platform to compare the groups of allergic multimorbidities against a single entity. Results: There were 659 (51.8%) males and 614 (48.2%) females aged from 4 months to 74 years included in the analysis. The study participants who were diagnosed with allergic diseases had an average of 1.6 diagnoses. Overall, 46.5% (592 of 1273) of the patients had more than one allergic condition, and allergic rhinitis was the most common type of multimorbidity. Women were more likely to suffer from an allergic disease alone, whereas allergic multimorbidities were more likely to be diagnosed in men (p = 0.005). In addition, allergic multimorbidities were common in all age groups, with an incidence ranging from 37.1% to 57.4%, in which children and adolescents were more frequently diagnosed with allergic multimorbidities than adults (18–60 years old) (all p < 0.05). Allergic multimorbidity was observed throughout the year. A difference in the positive rate of allergens sensitization and total immunoglobulin E (tIgE) levels between different allergic multimorbidities was observed. Conclusions: Allergic multimorbidities were very commonly found in nearly half of all patients with allergies. The proportion of allergic multimorbidities varied with the type of disease, sex, age, and allergen distribution pattern. These findings may help clinicians to develop “One health” strategies for the clinical management of allergic diseases. MDPI 2023-03-13 /pmc/articles/PMC10059830/ /pubmed/36983228 http://dx.doi.org/10.3390/jcm12062226 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Ya-Ting
Hou, Ming-Hui
Lu, Ya-Xin
Chen, Pei-Ran
Dai, Zhen-Yuan
Yang, Li-Fen
Zhang, Ping-Ping
Xiong, Guo-Wei
Liu, Zi-Feng
Zhou, Qi-Lin
Su, Jing
Cheng, Yun
Zhou, Yu-Qi
Tao, Jin
Huang, Xue-Kun
Dai, Min
Zhang, Kun
Zhou, Min
Yang, Qin-Tai
Feng, Pei-Ying
Chen, Zhuang-Gui
Multimorbidity of Allergic Conditions in Urban Citizens of Southern China: A Real-World Cross-Sectional Study
title Multimorbidity of Allergic Conditions in Urban Citizens of Southern China: A Real-World Cross-Sectional Study
title_full Multimorbidity of Allergic Conditions in Urban Citizens of Southern China: A Real-World Cross-Sectional Study
title_fullStr Multimorbidity of Allergic Conditions in Urban Citizens of Southern China: A Real-World Cross-Sectional Study
title_full_unstemmed Multimorbidity of Allergic Conditions in Urban Citizens of Southern China: A Real-World Cross-Sectional Study
title_short Multimorbidity of Allergic Conditions in Urban Citizens of Southern China: A Real-World Cross-Sectional Study
title_sort multimorbidity of allergic conditions in urban citizens of southern china: a real-world cross-sectional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10059830/
https://www.ncbi.nlm.nih.gov/pubmed/36983228
http://dx.doi.org/10.3390/jcm12062226
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