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Intracellular Membrane Transport in Vascular Endothelial Cells

The main component of blood and lymphatic vessels is the endothelium covering their luminal surface. It plays a significant role in many cardiovascular diseases. Tremendous progress has been made in deciphering of molecular mechanisms involved into intracellular transport. However, molecular machine...

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Autores principales: Mironov, Alexander A., Mironov, Anna, Sanavio, Barbara, Krol, Silke, Beznoussenko, Galina V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10059831/
https://www.ncbi.nlm.nih.gov/pubmed/36982865
http://dx.doi.org/10.3390/ijms24065791
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author Mironov, Alexander A.
Mironov, Anna
Sanavio, Barbara
Krol, Silke
Beznoussenko, Galina V.
author_facet Mironov, Alexander A.
Mironov, Anna
Sanavio, Barbara
Krol, Silke
Beznoussenko, Galina V.
author_sort Mironov, Alexander A.
collection PubMed
description The main component of blood and lymphatic vessels is the endothelium covering their luminal surface. It plays a significant role in many cardiovascular diseases. Tremendous progress has been made in deciphering of molecular mechanisms involved into intracellular transport. However, molecular machines are mostly characterized in vitro. It is important to adapt this knowledge to the situation existing in tissues and organs. Moreover, contradictions have accumulated within the field related to the function of endothelial cells (ECs) and their trans-endothelial pathways. This has induced necessity for the re-evaluation of several mechanisms related to the function of vascular ECs and intracellular transport and transcytosis there. Here, we analyze available data related to intracellular transport within ECs and re-examine several hypotheses about the role of different mechanisms in transcytosis across ECs. We propose a new classification of vascular endothelium and hypotheses related to the functional role of caveolae and mechanisms of lipid transport through ECs.
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spelling pubmed-100598312023-03-30 Intracellular Membrane Transport in Vascular Endothelial Cells Mironov, Alexander A. Mironov, Anna Sanavio, Barbara Krol, Silke Beznoussenko, Galina V. Int J Mol Sci Review The main component of blood and lymphatic vessels is the endothelium covering their luminal surface. It plays a significant role in many cardiovascular diseases. Tremendous progress has been made in deciphering of molecular mechanisms involved into intracellular transport. However, molecular machines are mostly characterized in vitro. It is important to adapt this knowledge to the situation existing in tissues and organs. Moreover, contradictions have accumulated within the field related to the function of endothelial cells (ECs) and their trans-endothelial pathways. This has induced necessity for the re-evaluation of several mechanisms related to the function of vascular ECs and intracellular transport and transcytosis there. Here, we analyze available data related to intracellular transport within ECs and re-examine several hypotheses about the role of different mechanisms in transcytosis across ECs. We propose a new classification of vascular endothelium and hypotheses related to the functional role of caveolae and mechanisms of lipid transport through ECs. MDPI 2023-03-17 /pmc/articles/PMC10059831/ /pubmed/36982865 http://dx.doi.org/10.3390/ijms24065791 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mironov, Alexander A.
Mironov, Anna
Sanavio, Barbara
Krol, Silke
Beznoussenko, Galina V.
Intracellular Membrane Transport in Vascular Endothelial Cells
title Intracellular Membrane Transport in Vascular Endothelial Cells
title_full Intracellular Membrane Transport in Vascular Endothelial Cells
title_fullStr Intracellular Membrane Transport in Vascular Endothelial Cells
title_full_unstemmed Intracellular Membrane Transport in Vascular Endothelial Cells
title_short Intracellular Membrane Transport in Vascular Endothelial Cells
title_sort intracellular membrane transport in vascular endothelial cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10059831/
https://www.ncbi.nlm.nih.gov/pubmed/36982865
http://dx.doi.org/10.3390/ijms24065791
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