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Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry
Background: The constraints in the management of patients with ST-segment elevation myocardial infarction (STEMI) during the COVID-19 pandemic have been suggested to have severely impacted mortality levels. The aim of the current analysis is to evaluate the age-related effects of the COVID-19 pandem...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10059932/ https://www.ncbi.nlm.nih.gov/pubmed/36983119 http://dx.doi.org/10.3390/jcm12062116 |
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author | De Luca, Giuseppe Algowhary, Magdy Uguz, Berat Oliveira, Dinaldo C. Ganyukov, Vladimir Busljetik, Oliver Cercek, Miha Jensen, Lisette Okkels Loh, Poay Huan Calmac, Lucian Ferrer, Gerard Roura i Quadros, Alexandre Milewski, Marek Scotto D’Uccio, Fortunato von Birgelen, Clemens Versaci, Francesco Ten Berg, Jurrien Casella, Gianni Wong Sung Lung, Aaron Kala, Petr Díez Gil, José Luis Carrillo, Xavier Dirksen, Maurits Becerra Munoz, Victor Lee, Michael Kang-yin Juzar, Dafsah Arifa de Moura Joaquim, Rodrigo Paladino, Roberto Milicic, Davor Davlouros, Periklis Bakraceski, Nikola Zilio, Filippo Donazzan, Luca Kraaijeveld, Adriaan Galasso, Gennaro Arpad, Lux Marinucci, Lucia Guiducci, Vincenzo Menichelli, Maurizio Scoccia, Alessandra Yamac, Aylin Hatice Ugur Mert, Kadir Flores Rios, Xacobe Kovarnik, Tomas Kidawa, Michal Moreu, Josè Flavien, Vincent Fabris, Enrico Martínez-Luengas, Iñigo Lozano Boccalatte, Marco Bosa Ojeda, Francisco Arellano-Serrano, Carlos Caiazzo, Gianluca Cirrincione, Giuseppe Kao, Hsien-Li Sanchis Forés, Juan Vignali, Luigi Pereira, Helder Manzo-Silberman, Stephane Ordoñez, Santiago Arat Özkan, Alev Scheller, Bruno Lehitola, Heidi Teles, Rui Mantis, Christos Antti, Ylitalo Brum Silveira, João António Zoni, Cesar Rodrigo Bessonov, Ivan Uccello, Giuseppe Kochiadakis, George Alexopulos, Dimitrios Uribe, Carlos E. Kanakakis, John Faurie, Benjamin Gabrielli, Gabriele Gutierrez Barrios, Alejandro Bachini, Juan Pablo Rocha, Alex Tam, Frankie C. C. Rodriguez, Alfredo Lukito, Antonia Anna Saint-Joy, Veauthyelau Pessah, Gustavo Tuccillo, Andrea Ielasi, Alfonso Cortese, Giuliana Parodi, Guido Burgadha, Mohammed Abed Kedhi, Elvin Lamelas, Pablo Suryapranata, Harry Nardin, Matteo Verdoia, Monica |
author_facet | De Luca, Giuseppe Algowhary, Magdy Uguz, Berat Oliveira, Dinaldo C. Ganyukov, Vladimir Busljetik, Oliver Cercek, Miha Jensen, Lisette Okkels Loh, Poay Huan Calmac, Lucian Ferrer, Gerard Roura i Quadros, Alexandre Milewski, Marek Scotto D’Uccio, Fortunato von Birgelen, Clemens Versaci, Francesco Ten Berg, Jurrien Casella, Gianni Wong Sung Lung, Aaron Kala, Petr Díez Gil, José Luis Carrillo, Xavier Dirksen, Maurits Becerra Munoz, Victor Lee, Michael Kang-yin Juzar, Dafsah Arifa de Moura Joaquim, Rodrigo Paladino, Roberto Milicic, Davor Davlouros, Periklis Bakraceski, Nikola Zilio, Filippo Donazzan, Luca Kraaijeveld, Adriaan Galasso, Gennaro Arpad, Lux Marinucci, Lucia Guiducci, Vincenzo Menichelli, Maurizio Scoccia, Alessandra Yamac, Aylin Hatice Ugur Mert, Kadir Flores Rios, Xacobe Kovarnik, Tomas Kidawa, Michal Moreu, Josè Flavien, Vincent Fabris, Enrico Martínez-Luengas, Iñigo Lozano Boccalatte, Marco Bosa Ojeda, Francisco Arellano-Serrano, Carlos Caiazzo, Gianluca Cirrincione, Giuseppe Kao, Hsien-Li Sanchis Forés, Juan Vignali, Luigi Pereira, Helder Manzo-Silberman, Stephane Ordoñez, Santiago Arat Özkan, Alev Scheller, Bruno Lehitola, Heidi Teles, Rui Mantis, Christos Antti, Ylitalo Brum Silveira, João António Zoni, Cesar Rodrigo Bessonov, Ivan Uccello, Giuseppe Kochiadakis, George Alexopulos, Dimitrios Uribe, Carlos E. Kanakakis, John Faurie, Benjamin Gabrielli, Gabriele Gutierrez Barrios, Alejandro Bachini, Juan Pablo Rocha, Alex Tam, Frankie C. C. Rodriguez, Alfredo Lukito, Antonia Anna Saint-Joy, Veauthyelau Pessah, Gustavo Tuccillo, Andrea Ielasi, Alfonso Cortese, Giuliana Parodi, Guido Burgadha, Mohammed Abed Kedhi, Elvin Lamelas, Pablo Suryapranata, Harry Nardin, Matteo Verdoia, Monica |
author_sort | De Luca, Giuseppe |
collection | PubMed |
description | Background: The constraints in the management of patients with ST-segment elevation myocardial infarction (STEMI) during the COVID-19 pandemic have been suggested to have severely impacted mortality levels. The aim of the current analysis is to evaluate the age-related effects of the COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI within the registry ISACS-STEMI COVID-19. Methods: This retrospective multicenter registry was performed in high-volume PPCI centers on four continents and included STEMI patients undergoing PPCI in March–June 2019 and 2020. Patients were divided according to age (< or ≥75 years). The main outcomes were the incidence and timing of PPCI, (ischemia time longer than 12 h and door-to-balloon longer than 30 min), and in-hospital or 30-day mortality. Results: We included 16,683 patients undergoing PPCI in 109 centers. In 2020, during the pandemic, there was a significant reduction in PPCI as compared to 2019 (IRR 0.843 (95%-CI: 0.825–0.861, p < 0.0001). We found a significant age-related reduction (7%, p = 0.015), with a larger effect on elderly than on younger patients. Furthermore, we observed significantly higher 30-day mortality during the pandemic period, especially among the elderly (13.6% vs. 17.9%, adjusted HR (95% CI) = 1.55 [1.24–1.93], p < 0.001) as compared to younger patients (4.8% vs. 5.7%; adjusted HR (95% CI) = 1.25 [1.05–1.49], p = 0.013), as a potential consequence of the significantly longer ischemia time observed during the pandemic. Conclusions: The COVID-19 pandemic had a significant impact on the treatment of patients with STEMI, with a 16% reduction in PPCI procedures, with a larger reduction and a longer delay to treatment among elderly patients, which may have contributed to increase in-hospital and 30-day mortality during the pandemic. |
format | Online Article Text |
id | pubmed-10059932 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100599322023-03-30 Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry De Luca, Giuseppe Algowhary, Magdy Uguz, Berat Oliveira, Dinaldo C. Ganyukov, Vladimir Busljetik, Oliver Cercek, Miha Jensen, Lisette Okkels Loh, Poay Huan Calmac, Lucian Ferrer, Gerard Roura i Quadros, Alexandre Milewski, Marek Scotto D’Uccio, Fortunato von Birgelen, Clemens Versaci, Francesco Ten Berg, Jurrien Casella, Gianni Wong Sung Lung, Aaron Kala, Petr Díez Gil, José Luis Carrillo, Xavier Dirksen, Maurits Becerra Munoz, Victor Lee, Michael Kang-yin Juzar, Dafsah Arifa de Moura Joaquim, Rodrigo Paladino, Roberto Milicic, Davor Davlouros, Periklis Bakraceski, Nikola Zilio, Filippo Donazzan, Luca Kraaijeveld, Adriaan Galasso, Gennaro Arpad, Lux Marinucci, Lucia Guiducci, Vincenzo Menichelli, Maurizio Scoccia, Alessandra Yamac, Aylin Hatice Ugur Mert, Kadir Flores Rios, Xacobe Kovarnik, Tomas Kidawa, Michal Moreu, Josè Flavien, Vincent Fabris, Enrico Martínez-Luengas, Iñigo Lozano Boccalatte, Marco Bosa Ojeda, Francisco Arellano-Serrano, Carlos Caiazzo, Gianluca Cirrincione, Giuseppe Kao, Hsien-Li Sanchis Forés, Juan Vignali, Luigi Pereira, Helder Manzo-Silberman, Stephane Ordoñez, Santiago Arat Özkan, Alev Scheller, Bruno Lehitola, Heidi Teles, Rui Mantis, Christos Antti, Ylitalo Brum Silveira, João António Zoni, Cesar Rodrigo Bessonov, Ivan Uccello, Giuseppe Kochiadakis, George Alexopulos, Dimitrios Uribe, Carlos E. Kanakakis, John Faurie, Benjamin Gabrielli, Gabriele Gutierrez Barrios, Alejandro Bachini, Juan Pablo Rocha, Alex Tam, Frankie C. C. Rodriguez, Alfredo Lukito, Antonia Anna Saint-Joy, Veauthyelau Pessah, Gustavo Tuccillo, Andrea Ielasi, Alfonso Cortese, Giuliana Parodi, Guido Burgadha, Mohammed Abed Kedhi, Elvin Lamelas, Pablo Suryapranata, Harry Nardin, Matteo Verdoia, Monica J Clin Med Article Background: The constraints in the management of patients with ST-segment elevation myocardial infarction (STEMI) during the COVID-19 pandemic have been suggested to have severely impacted mortality levels. The aim of the current analysis is to evaluate the age-related effects of the COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI within the registry ISACS-STEMI COVID-19. Methods: This retrospective multicenter registry was performed in high-volume PPCI centers on four continents and included STEMI patients undergoing PPCI in March–June 2019 and 2020. Patients were divided according to age (< or ≥75 years). The main outcomes were the incidence and timing of PPCI, (ischemia time longer than 12 h and door-to-balloon longer than 30 min), and in-hospital or 30-day mortality. Results: We included 16,683 patients undergoing PPCI in 109 centers. In 2020, during the pandemic, there was a significant reduction in PPCI as compared to 2019 (IRR 0.843 (95%-CI: 0.825–0.861, p < 0.0001). We found a significant age-related reduction (7%, p = 0.015), with a larger effect on elderly than on younger patients. Furthermore, we observed significantly higher 30-day mortality during the pandemic period, especially among the elderly (13.6% vs. 17.9%, adjusted HR (95% CI) = 1.55 [1.24–1.93], p < 0.001) as compared to younger patients (4.8% vs. 5.7%; adjusted HR (95% CI) = 1.25 [1.05–1.49], p = 0.013), as a potential consequence of the significantly longer ischemia time observed during the pandemic. Conclusions: The COVID-19 pandemic had a significant impact on the treatment of patients with STEMI, with a 16% reduction in PPCI procedures, with a larger reduction and a longer delay to treatment among elderly patients, which may have contributed to increase in-hospital and 30-day mortality during the pandemic. MDPI 2023-03-08 /pmc/articles/PMC10059932/ /pubmed/36983119 http://dx.doi.org/10.3390/jcm12062116 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article De Luca, Giuseppe Algowhary, Magdy Uguz, Berat Oliveira, Dinaldo C. Ganyukov, Vladimir Busljetik, Oliver Cercek, Miha Jensen, Lisette Okkels Loh, Poay Huan Calmac, Lucian Ferrer, Gerard Roura i Quadros, Alexandre Milewski, Marek Scotto D’Uccio, Fortunato von Birgelen, Clemens Versaci, Francesco Ten Berg, Jurrien Casella, Gianni Wong Sung Lung, Aaron Kala, Petr Díez Gil, José Luis Carrillo, Xavier Dirksen, Maurits Becerra Munoz, Victor Lee, Michael Kang-yin Juzar, Dafsah Arifa de Moura Joaquim, Rodrigo Paladino, Roberto Milicic, Davor Davlouros, Periklis Bakraceski, Nikola Zilio, Filippo Donazzan, Luca Kraaijeveld, Adriaan Galasso, Gennaro Arpad, Lux Marinucci, Lucia Guiducci, Vincenzo Menichelli, Maurizio Scoccia, Alessandra Yamac, Aylin Hatice Ugur Mert, Kadir Flores Rios, Xacobe Kovarnik, Tomas Kidawa, Michal Moreu, Josè Flavien, Vincent Fabris, Enrico Martínez-Luengas, Iñigo Lozano Boccalatte, Marco Bosa Ojeda, Francisco Arellano-Serrano, Carlos Caiazzo, Gianluca Cirrincione, Giuseppe Kao, Hsien-Li Sanchis Forés, Juan Vignali, Luigi Pereira, Helder Manzo-Silberman, Stephane Ordoñez, Santiago Arat Özkan, Alev Scheller, Bruno Lehitola, Heidi Teles, Rui Mantis, Christos Antti, Ylitalo Brum Silveira, João António Zoni, Cesar Rodrigo Bessonov, Ivan Uccello, Giuseppe Kochiadakis, George Alexopulos, Dimitrios Uribe, Carlos E. Kanakakis, John Faurie, Benjamin Gabrielli, Gabriele Gutierrez Barrios, Alejandro Bachini, Juan Pablo Rocha, Alex Tam, Frankie C. C. Rodriguez, Alfredo Lukito, Antonia Anna Saint-Joy, Veauthyelau Pessah, Gustavo Tuccillo, Andrea Ielasi, Alfonso Cortese, Giuliana Parodi, Guido Burgadha, Mohammed Abed Kedhi, Elvin Lamelas, Pablo Suryapranata, Harry Nardin, Matteo Verdoia, Monica Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry |
title | Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry |
title_full | Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry |
title_fullStr | Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry |
title_full_unstemmed | Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry |
title_short | Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry |
title_sort | age-related effects of covid-19 pandemic on mechanical reperfusion and 30-day mortality for stemi: results of the isacs-stemi covid-19 registry |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10059932/ https://www.ncbi.nlm.nih.gov/pubmed/36983119 http://dx.doi.org/10.3390/jcm12062116 |
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