Combined Dopamine and Grape Seed Extract-Loaded Solid Lipid Nanoparticles: Nasal Mucosa Permeation, and Uptake by Olfactory Ensheathing Cells and Neuronal SH-SY5Y Cells †

We have already formulated solid lipid nanoparticles (SLNs) in which the combination of the neurotransmitter dopamine (DA) and the antioxidant grape-seed-derived proanthocyanidins (grape seed extract, GSE) was supposed to be favorable for Parkinson’s disease (PD) treatment. In fact, GSE supply would...

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Detalles Bibliográficos
Autores principales: Trapani, Adriana, Castellani, Stefano, Guerra, Lorenzo, De Giglio, Elvira, Fracchiolla, Giuseppe, Corbo, Filomena, Cioffi, Nicola, Passantino, Giuseppe, Poeta, Maria Luana, Montemurro, Pasqualina, Mallamaci, Rosanna, Cardone, Rosa Angela, Conese, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10059967/
https://www.ncbi.nlm.nih.gov/pubmed/36986742
http://dx.doi.org/10.3390/pharmaceutics15030881

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