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Relationship between Muscle Mass, Bone Density and Vascular Calcifications in Elderly People with SARS-CoV-2 Pneumonia

Background: Little is known about the changes in organs and tissues that may make elder patients more vulnerable to acute stressors such as SARS-CoV-2 infection. Methods: In 80 consecutive elderly patients with SARS-CoV-2 infection, we evaluated the association between the descending thoracic aorta...

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Autores principales: Del Toro, Rossella, Palmese, Francesco, Feletti, Francesco, Zani, Gianluca, Minguzzi, Maria Teresa, Maddaloni, Ernesto, Napoli, Nicola, Bedogni, Giorgio, Domenicali, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10059976/
https://www.ncbi.nlm.nih.gov/pubmed/36983372
http://dx.doi.org/10.3390/jcm12062372
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author Del Toro, Rossella
Palmese, Francesco
Feletti, Francesco
Zani, Gianluca
Minguzzi, Maria Teresa
Maddaloni, Ernesto
Napoli, Nicola
Bedogni, Giorgio
Domenicali, Marco
author_facet Del Toro, Rossella
Palmese, Francesco
Feletti, Francesco
Zani, Gianluca
Minguzzi, Maria Teresa
Maddaloni, Ernesto
Napoli, Nicola
Bedogni, Giorgio
Domenicali, Marco
author_sort Del Toro, Rossella
collection PubMed
description Background: Little is known about the changes in organs and tissues that may make elder patients more vulnerable to acute stressors such as SARS-CoV-2 infection. Methods: In 80 consecutive elderly patients with SARS-CoV-2 infection, we evaluated the association between the descending thoracic aorta calcium score, L1 bone density and T12 skeletal muscle density measured on the same scan by high-resolution computed tomography. Results: At median regression, the ln-transformed DTA calcium score was inversely associated with L1 bone density (−0.02, 95%CI −0.04 to −0.01 ln-Agatston units for an increase of 1 HU) and with T12 muscle density (−0.03, −0.06 to −0.001 ln-Agatston units for an increase of 1 HU). At penalized logistic regression, an increase of 1 ln-Agatston unit of DTA calcium score was associated with an OR of death of 1.480 (1.022 to 2.145), one of 1 HU of bone density with an OR of 0.981 (0.966 to 0.996) and one of 1 HU of muscle density with an OR of 0.973 (0.948 to 0.999). These relationships disappeared after correction for age and age was the stronger predictor of body composition and death. Conclusions: Age has a big effect on the relationship between vascular calcifications, L1 bone density and T12 muscle density and on their relationship with the odds of dying.
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spelling pubmed-100599762023-03-30 Relationship between Muscle Mass, Bone Density and Vascular Calcifications in Elderly People with SARS-CoV-2 Pneumonia Del Toro, Rossella Palmese, Francesco Feletti, Francesco Zani, Gianluca Minguzzi, Maria Teresa Maddaloni, Ernesto Napoli, Nicola Bedogni, Giorgio Domenicali, Marco J Clin Med Article Background: Little is known about the changes in organs and tissues that may make elder patients more vulnerable to acute stressors such as SARS-CoV-2 infection. Methods: In 80 consecutive elderly patients with SARS-CoV-2 infection, we evaluated the association between the descending thoracic aorta calcium score, L1 bone density and T12 skeletal muscle density measured on the same scan by high-resolution computed tomography. Results: At median regression, the ln-transformed DTA calcium score was inversely associated with L1 bone density (−0.02, 95%CI −0.04 to −0.01 ln-Agatston units for an increase of 1 HU) and with T12 muscle density (−0.03, −0.06 to −0.001 ln-Agatston units for an increase of 1 HU). At penalized logistic regression, an increase of 1 ln-Agatston unit of DTA calcium score was associated with an OR of death of 1.480 (1.022 to 2.145), one of 1 HU of bone density with an OR of 0.981 (0.966 to 0.996) and one of 1 HU of muscle density with an OR of 0.973 (0.948 to 0.999). These relationships disappeared after correction for age and age was the stronger predictor of body composition and death. Conclusions: Age has a big effect on the relationship between vascular calcifications, L1 bone density and T12 muscle density and on their relationship with the odds of dying. MDPI 2023-03-19 /pmc/articles/PMC10059976/ /pubmed/36983372 http://dx.doi.org/10.3390/jcm12062372 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Del Toro, Rossella
Palmese, Francesco
Feletti, Francesco
Zani, Gianluca
Minguzzi, Maria Teresa
Maddaloni, Ernesto
Napoli, Nicola
Bedogni, Giorgio
Domenicali, Marco
Relationship between Muscle Mass, Bone Density and Vascular Calcifications in Elderly People with SARS-CoV-2 Pneumonia
title Relationship between Muscle Mass, Bone Density and Vascular Calcifications in Elderly People with SARS-CoV-2 Pneumonia
title_full Relationship between Muscle Mass, Bone Density and Vascular Calcifications in Elderly People with SARS-CoV-2 Pneumonia
title_fullStr Relationship between Muscle Mass, Bone Density and Vascular Calcifications in Elderly People with SARS-CoV-2 Pneumonia
title_full_unstemmed Relationship between Muscle Mass, Bone Density and Vascular Calcifications in Elderly People with SARS-CoV-2 Pneumonia
title_short Relationship between Muscle Mass, Bone Density and Vascular Calcifications in Elderly People with SARS-CoV-2 Pneumonia
title_sort relationship between muscle mass, bone density and vascular calcifications in elderly people with sars-cov-2 pneumonia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10059976/
https://www.ncbi.nlm.nih.gov/pubmed/36983372
http://dx.doi.org/10.3390/jcm12062372
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