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COVID-19 vaccine uptake trends in SARS-CoV-2 previously infected cancer patients
PURPOSE: Cancer patients are at high risk of developing severe illness from SARS-CoV-2 infection, but risk is lowered with receipt of COVID-19 vaccine. COVID-19 vaccination uptake among previously infected cancer patients may be influenced by an assumption of natural immunity, predicted weak immune...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060025/ https://www.ncbi.nlm.nih.gov/pubmed/37020982 http://dx.doi.org/10.1016/j.jvacx.2023.100289 |
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author | Shahid, Zainab Patrick, Alicia L. Wallander, Michelle L. Donahue, Erin E. Trufan, Sally J. Tan, Antoinette R. Hwang, Jimmy J. Burgess, Earle F. Ragon, Brittany Ghosh, Nilanjan Grunwald, Michael R. Voorhees, Peter M. Copelan, Edward A. Raghavan, Derek |
author_facet | Shahid, Zainab Patrick, Alicia L. Wallander, Michelle L. Donahue, Erin E. Trufan, Sally J. Tan, Antoinette R. Hwang, Jimmy J. Burgess, Earle F. Ragon, Brittany Ghosh, Nilanjan Grunwald, Michael R. Voorhees, Peter M. Copelan, Edward A. Raghavan, Derek |
author_sort | Shahid, Zainab |
collection | PubMed |
description | PURPOSE: Cancer patients are at high risk of developing severe illness from SARS-CoV-2 infection, but risk is lowered with receipt of COVID-19 vaccine. COVID-19 vaccination uptake among previously infected cancer patients may be influenced by an assumption of natural immunity, predicted weak immune response, or concerns about vaccine safety. The objective of this study was to evaluate COVID-19 vaccine uptake trends in cancer patients previously infected with SARS-CoV-2. MATERIALS AND METHODS: Medical records of 579 sequential cancer patients undergoing active treatment at Levine Cancer Institute who tested positive for COVID-19 between January 2020 and January 2021 were evaluated. Patients who died prior to vaccine eligibility were excluded from the analysis. Demographic, clinical, and COVID-19 related characteristics were analyzed to identify prognostic factors for COVID-19 vaccine uptake as this information could be important for health policy design for future pandemics. RESULTS: Eighty-one patients died prior to the availability of COVID-19 vaccines. The acceptance rate of COVID-19 vaccination among 498 previously infected cancer patients was 54.6%. Of the patients with known vaccination dates, 76.8% received their first vaccine by April 17th, 2021. As of November 30, 2021, 23.7.% of eligible patients were boosted. In univariate models, older age, female sex, higher income, solid tumor cancer type, and hormone therapy were significantly associated with higher vaccine uptake, while Hispanic/Latino ethnicity was significantly associated with lower vaccine uptake. In a multivariable model, age (OR 1.18, 95% CI 1.10–1.28; p < 0.001), female sex (OR 1.80, 95% CI 1.22–2.66; p = 0.003), and higher income (OR 1.11, 95% CI 1.01–1.22; p = 0.032), were predictive of COVID-19 vaccine uptake. CONCLUSIONS: Overall, vaccine uptake was low among our cohort of previously infected cancer patients. Older age, female sex, and higher income were the only variables associated with COVID-19 vaccine uptake within this vulnerable patient population. |
format | Online Article Text |
id | pubmed-10060025 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-100600252023-03-30 COVID-19 vaccine uptake trends in SARS-CoV-2 previously infected cancer patients Shahid, Zainab Patrick, Alicia L. Wallander, Michelle L. Donahue, Erin E. Trufan, Sally J. Tan, Antoinette R. Hwang, Jimmy J. Burgess, Earle F. Ragon, Brittany Ghosh, Nilanjan Grunwald, Michael R. Voorhees, Peter M. Copelan, Edward A. Raghavan, Derek Vaccine X Regular paper PURPOSE: Cancer patients are at high risk of developing severe illness from SARS-CoV-2 infection, but risk is lowered with receipt of COVID-19 vaccine. COVID-19 vaccination uptake among previously infected cancer patients may be influenced by an assumption of natural immunity, predicted weak immune response, or concerns about vaccine safety. The objective of this study was to evaluate COVID-19 vaccine uptake trends in cancer patients previously infected with SARS-CoV-2. MATERIALS AND METHODS: Medical records of 579 sequential cancer patients undergoing active treatment at Levine Cancer Institute who tested positive for COVID-19 between January 2020 and January 2021 were evaluated. Patients who died prior to vaccine eligibility were excluded from the analysis. Demographic, clinical, and COVID-19 related characteristics were analyzed to identify prognostic factors for COVID-19 vaccine uptake as this information could be important for health policy design for future pandemics. RESULTS: Eighty-one patients died prior to the availability of COVID-19 vaccines. The acceptance rate of COVID-19 vaccination among 498 previously infected cancer patients was 54.6%. Of the patients with known vaccination dates, 76.8% received their first vaccine by April 17th, 2021. As of November 30, 2021, 23.7.% of eligible patients were boosted. In univariate models, older age, female sex, higher income, solid tumor cancer type, and hormone therapy were significantly associated with higher vaccine uptake, while Hispanic/Latino ethnicity was significantly associated with lower vaccine uptake. In a multivariable model, age (OR 1.18, 95% CI 1.10–1.28; p < 0.001), female sex (OR 1.80, 95% CI 1.22–2.66; p = 0.003), and higher income (OR 1.11, 95% CI 1.01–1.22; p = 0.032), were predictive of COVID-19 vaccine uptake. CONCLUSIONS: Overall, vaccine uptake was low among our cohort of previously infected cancer patients. Older age, female sex, and higher income were the only variables associated with COVID-19 vaccine uptake within this vulnerable patient population. Elsevier 2023-03-30 /pmc/articles/PMC10060025/ /pubmed/37020982 http://dx.doi.org/10.1016/j.jvacx.2023.100289 Text en © 2023 Published by Elsevier Ltd. |
spellingShingle | Regular paper Shahid, Zainab Patrick, Alicia L. Wallander, Michelle L. Donahue, Erin E. Trufan, Sally J. Tan, Antoinette R. Hwang, Jimmy J. Burgess, Earle F. Ragon, Brittany Ghosh, Nilanjan Grunwald, Michael R. Voorhees, Peter M. Copelan, Edward A. Raghavan, Derek COVID-19 vaccine uptake trends in SARS-CoV-2 previously infected cancer patients |
title | COVID-19 vaccine uptake trends in SARS-CoV-2 previously infected cancer patients |
title_full | COVID-19 vaccine uptake trends in SARS-CoV-2 previously infected cancer patients |
title_fullStr | COVID-19 vaccine uptake trends in SARS-CoV-2 previously infected cancer patients |
title_full_unstemmed | COVID-19 vaccine uptake trends in SARS-CoV-2 previously infected cancer patients |
title_short | COVID-19 vaccine uptake trends in SARS-CoV-2 previously infected cancer patients |
title_sort | covid-19 vaccine uptake trends in sars-cov-2 previously infected cancer patients |
topic | Regular paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060025/ https://www.ncbi.nlm.nih.gov/pubmed/37020982 http://dx.doi.org/10.1016/j.jvacx.2023.100289 |
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