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Monkeypox-Associated Disciform Keratitis

The purpose of this study was to describe a case of monkeypox (MPX)-associated disciform keratitis. METHODS: This is a case report. RESULTS: A 36-year-old male patient presented to the infectious diseases clinic with a 1-week history of disseminated pustular skin lesions, a 4-day history of constitu...

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Autores principales: Alsarhani, Waleed K., Chan, Clara C., Boyd, Shelley R., Hasso, Maan, Almeer, Ahmed, Tan, Darrell H. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cornea 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060039/
https://www.ncbi.nlm.nih.gov/pubmed/36729600
http://dx.doi.org/10.1097/ICO.0000000000003171
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author Alsarhani, Waleed K.
Chan, Clara C.
Boyd, Shelley R.
Hasso, Maan
Almeer, Ahmed
Tan, Darrell H. S.
author_facet Alsarhani, Waleed K.
Chan, Clara C.
Boyd, Shelley R.
Hasso, Maan
Almeer, Ahmed
Tan, Darrell H. S.
author_sort Alsarhani, Waleed K.
collection PubMed
description The purpose of this study was to describe a case of monkeypox (MPX)-associated disciform keratitis. METHODS: This is a case report. RESULTS: A 36-year-old male patient presented to the infectious diseases clinic with a 1-week history of disseminated pustular skin lesions, a 4-day history of constitutional symptoms, and redness in the left eye. Testing of blood, 2 skin lesions, and a conjunctival swab confirmed the presence of MPX virus by polymerase chain reaction. On ophthalmologic examination on the 17th day of illness, there was a corneal epithelial ridge that stained with fluorescein with disciform corneal edema and underlying keratic precipitates. The patient was treated with oral tecovirimat 600 mg twice a day for 14 days and topical prednisolone acetate 1% 4 times daily, starting 2 days later. On completion of oral treatment, his corneal findings had resolved except for a small subepithelial scar at which time topical steroids were tapered. CONCLUSIONS: MPX may cause disciform keratitis and scarring that closely resembles other ocular viral infections. Clinical trials are urgently needed to define the optimal management of human MPX infections and reduce vision loss.
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spelling pubmed-100600392023-03-30 Monkeypox-Associated Disciform Keratitis Alsarhani, Waleed K. Chan, Clara C. Boyd, Shelley R. Hasso, Maan Almeer, Ahmed Tan, Darrell H. S. Cornea Case Report The purpose of this study was to describe a case of monkeypox (MPX)-associated disciform keratitis. METHODS: This is a case report. RESULTS: A 36-year-old male patient presented to the infectious diseases clinic with a 1-week history of disseminated pustular skin lesions, a 4-day history of constitutional symptoms, and redness in the left eye. Testing of blood, 2 skin lesions, and a conjunctival swab confirmed the presence of MPX virus by polymerase chain reaction. On ophthalmologic examination on the 17th day of illness, there was a corneal epithelial ridge that stained with fluorescein with disciform corneal edema and underlying keratic precipitates. The patient was treated with oral tecovirimat 600 mg twice a day for 14 days and topical prednisolone acetate 1% 4 times daily, starting 2 days later. On completion of oral treatment, his corneal findings had resolved except for a small subepithelial scar at which time topical steroids were tapered. CONCLUSIONS: MPX may cause disciform keratitis and scarring that closely resembles other ocular viral infections. Clinical trials are urgently needed to define the optimal management of human MPX infections and reduce vision loss. Cornea 2023-05 2022-12-09 /pmc/articles/PMC10060039/ /pubmed/36729600 http://dx.doi.org/10.1097/ICO.0000000000003171 Text en Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Alsarhani, Waleed K.
Chan, Clara C.
Boyd, Shelley R.
Hasso, Maan
Almeer, Ahmed
Tan, Darrell H. S.
Monkeypox-Associated Disciform Keratitis
title Monkeypox-Associated Disciform Keratitis
title_full Monkeypox-Associated Disciform Keratitis
title_fullStr Monkeypox-Associated Disciform Keratitis
title_full_unstemmed Monkeypox-Associated Disciform Keratitis
title_short Monkeypox-Associated Disciform Keratitis
title_sort monkeypox-associated disciform keratitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060039/
https://www.ncbi.nlm.nih.gov/pubmed/36729600
http://dx.doi.org/10.1097/ICO.0000000000003171
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