Circulating monocytes associated with anti-PD-1 resistance in human biliary cancer induce T cell paralysis

Suppressive myeloid cells can contribute to immunotherapy resistance, but their role in response to checkpoint inhibition (CPI) in anti-PD-1 refractory cancers, such as biliary tract cancer (BTC), remains elusive. We use multiplexed single-cell transcriptomic and epitope sequencing to profile greate...

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Detalles Bibliográficos
Autores principales: Keenan, Bridget P., McCarthy, Elizabeth E., Ilano, Arielle, Yang, Hai, Zhang, Li, Allaire, Kathryn, Fan, Zenghua, Li, Tony, Lee, David S., Sun, Yang, Cheung, Alexander, Luong, Diamond, Chang, Hewitt, Chen, Brandon, Marquez, Jaqueline, Sheldon, Brenna, Kelley, Robin K., Ye, Chun Jimmie, Fong, Lawrence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060099/
https://www.ncbi.nlm.nih.gov/pubmed/36130508
http://dx.doi.org/10.1016/j.celrep.2022.111384

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