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White matter disconnection of left multiple demand network is associated with post-lesion deficits in cognitive control

Cognitive control modulates other cognitive functions to achieve internal goals and is important for adaptive behavior. Cognitive control is enabled by the neural computations distributed over cortical and subcortical areas. However, due to technical challenges in recording neural activity from the...

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Autores principales: Jiang, Jiefeng, Bruss, Joel, Lee, Woo-Tek, Tranel, Daniel, Boes, Aaron D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060223/
https://www.ncbi.nlm.nih.gov/pubmed/36990985
http://dx.doi.org/10.1038/s41467-023-37330-1
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author Jiang, Jiefeng
Bruss, Joel
Lee, Woo-Tek
Tranel, Daniel
Boes, Aaron D.
author_facet Jiang, Jiefeng
Bruss, Joel
Lee, Woo-Tek
Tranel, Daniel
Boes, Aaron D.
author_sort Jiang, Jiefeng
collection PubMed
description Cognitive control modulates other cognitive functions to achieve internal goals and is important for adaptive behavior. Cognitive control is enabled by the neural computations distributed over cortical and subcortical areas. However, due to technical challenges in recording neural activity from the white matter, little is known about the anatomy of white matter tracts that coordinate the distributed neural computations that support cognitive control. Here, we leverage a large sample of human patients with focal brain lesions (n = 643) and investigate how lesion location and connectivity profiles account for variance in cognitive control performance. We find that lesions in white matter connecting left frontoparietal regions of the multiple demand network reliably predict deficits in cognitive control performance. These findings advance our understanding of the white matter correlates of cognitive control and provide an approach for incorporating network disconnection to predict deficits following lesions.
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spelling pubmed-100602232023-03-31 White matter disconnection of left multiple demand network is associated with post-lesion deficits in cognitive control Jiang, Jiefeng Bruss, Joel Lee, Woo-Tek Tranel, Daniel Boes, Aaron D. Nat Commun Article Cognitive control modulates other cognitive functions to achieve internal goals and is important for adaptive behavior. Cognitive control is enabled by the neural computations distributed over cortical and subcortical areas. However, due to technical challenges in recording neural activity from the white matter, little is known about the anatomy of white matter tracts that coordinate the distributed neural computations that support cognitive control. Here, we leverage a large sample of human patients with focal brain lesions (n = 643) and investigate how lesion location and connectivity profiles account for variance in cognitive control performance. We find that lesions in white matter connecting left frontoparietal regions of the multiple demand network reliably predict deficits in cognitive control performance. These findings advance our understanding of the white matter correlates of cognitive control and provide an approach for incorporating network disconnection to predict deficits following lesions. Nature Publishing Group UK 2023-03-29 /pmc/articles/PMC10060223/ /pubmed/36990985 http://dx.doi.org/10.1038/s41467-023-37330-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Jiang, Jiefeng
Bruss, Joel
Lee, Woo-Tek
Tranel, Daniel
Boes, Aaron D.
White matter disconnection of left multiple demand network is associated with post-lesion deficits in cognitive control
title White matter disconnection of left multiple demand network is associated with post-lesion deficits in cognitive control
title_full White matter disconnection of left multiple demand network is associated with post-lesion deficits in cognitive control
title_fullStr White matter disconnection of left multiple demand network is associated with post-lesion deficits in cognitive control
title_full_unstemmed White matter disconnection of left multiple demand network is associated with post-lesion deficits in cognitive control
title_short White matter disconnection of left multiple demand network is associated with post-lesion deficits in cognitive control
title_sort white matter disconnection of left multiple demand network is associated with post-lesion deficits in cognitive control
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060223/
https://www.ncbi.nlm.nih.gov/pubmed/36990985
http://dx.doi.org/10.1038/s41467-023-37330-1
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