Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance

Telomere length maintenance is essential for cellular immortalization and tumorigenesis. 5% − 10% of human cancers rely on a recombination-based mechanism termed alternative lengthening of telomeres (ALT) to sustain their replicative immortality, yet there are currently no targeted therapies. Throug...

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Detalles Bibliográficos
Autores principales: Li, Fei, Wang, Yizhe, Hwang, Inah, Jang, Ja-Young, Xu, Libo, Deng, Zhong, Yu, Eun Young, Cai, Yiming, Wu, Caizhi, Han, Zhenbo, Huang, Yu-Han, Huang, Xiangao, Zhang, Ling, Yao, Jun, Lue, Neal F., Lieberman, Paul M., Ying, Haoqiang, Paik, Jihye, Zheng, Hongwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060224/
https://www.ncbi.nlm.nih.gov/pubmed/36991019
http://dx.doi.org/10.1038/s41467-023-37480-2

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