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Physical performance capacity after pediatric kidney transplant and clinical parameters associated with physical performance capacity

BACKGROUND: History of chronic kidney disease and kidney transplantation is known to influence physical performance capacity. The aim of this study was to compare the physical performance of pediatric kidney transplant recipients to healthy controls and to find possible correlations between clinical...

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Autores principales: Mäenpää, Heidi, Tainio, Juuso, Arokoski, Jari, Jahnukainen, Timo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060344/
https://www.ncbi.nlm.nih.gov/pubmed/36315277
http://dx.doi.org/10.1007/s00467-022-05758-0
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author Mäenpää, Heidi
Tainio, Juuso
Arokoski, Jari
Jahnukainen, Timo
author_facet Mäenpää, Heidi
Tainio, Juuso
Arokoski, Jari
Jahnukainen, Timo
author_sort Mäenpää, Heidi
collection PubMed
description BACKGROUND: History of chronic kidney disease and kidney transplantation is known to influence physical performance capacity. The aim of this study was to compare the physical performance of pediatric kidney transplant recipients to healthy controls and to find possible correlations between clinical parameters and physical performance capacity. METHODS: Twenty-four pediatric kidney transplant recipients (62.5% boys) were tested at a median age of 10.8 years. Physical performance capacity was tested with a test set including six different components assessing muscle endurance, strength, speed, and flexibility. The control group consisted of 273 healthy age-matched schoolchildren. Clinical parameters were collected as part of routine follow-up protocol. The majority of patients (62.5%) had congenital nephrotic syndrome of Finnish type (CNS) as primary diagnosis, and therefore, the results of CNS recipients were compared to the other disease groups. RESULTS: The physical performance capacity in pediatric kidney transplant recipients was lower compared to healthy controls. Surprisingly, no statistically significant correlation was found between graft function and physical performance capacity. The CNS patients scored worse than patients with other diagnoses in all test domains except for sit-and-reach and shuttle run, but the differences did not reach statistical significance. CONCLUSION: The physical performance of pediatric kidney transplant recipients is reduced, especially in those with congenital nephrotic syndrome. Clinical parameters, including graft function, did not predict physical performance capacity, suggesting that the reduced physical performance seems to be of multivariable cause. GRAPHICAL ABSTRACT: [Figure: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00467-022-05758-0.
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spelling pubmed-100603442023-03-31 Physical performance capacity after pediatric kidney transplant and clinical parameters associated with physical performance capacity Mäenpää, Heidi Tainio, Juuso Arokoski, Jari Jahnukainen, Timo Pediatr Nephrol Original Article BACKGROUND: History of chronic kidney disease and kidney transplantation is known to influence physical performance capacity. The aim of this study was to compare the physical performance of pediatric kidney transplant recipients to healthy controls and to find possible correlations between clinical parameters and physical performance capacity. METHODS: Twenty-four pediatric kidney transplant recipients (62.5% boys) were tested at a median age of 10.8 years. Physical performance capacity was tested with a test set including six different components assessing muscle endurance, strength, speed, and flexibility. The control group consisted of 273 healthy age-matched schoolchildren. Clinical parameters were collected as part of routine follow-up protocol. The majority of patients (62.5%) had congenital nephrotic syndrome of Finnish type (CNS) as primary diagnosis, and therefore, the results of CNS recipients were compared to the other disease groups. RESULTS: The physical performance capacity in pediatric kidney transplant recipients was lower compared to healthy controls. Surprisingly, no statistically significant correlation was found between graft function and physical performance capacity. The CNS patients scored worse than patients with other diagnoses in all test domains except for sit-and-reach and shuttle run, but the differences did not reach statistical significance. CONCLUSION: The physical performance of pediatric kidney transplant recipients is reduced, especially in those with congenital nephrotic syndrome. Clinical parameters, including graft function, did not predict physical performance capacity, suggesting that the reduced physical performance seems to be of multivariable cause. GRAPHICAL ABSTRACT: [Figure: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00467-022-05758-0. Springer Berlin Heidelberg 2022-10-31 2023 /pmc/articles/PMC10060344/ /pubmed/36315277 http://dx.doi.org/10.1007/s00467-022-05758-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Mäenpää, Heidi
Tainio, Juuso
Arokoski, Jari
Jahnukainen, Timo
Physical performance capacity after pediatric kidney transplant and clinical parameters associated with physical performance capacity
title Physical performance capacity after pediatric kidney transplant and clinical parameters associated with physical performance capacity
title_full Physical performance capacity after pediatric kidney transplant and clinical parameters associated with physical performance capacity
title_fullStr Physical performance capacity after pediatric kidney transplant and clinical parameters associated with physical performance capacity
title_full_unstemmed Physical performance capacity after pediatric kidney transplant and clinical parameters associated with physical performance capacity
title_short Physical performance capacity after pediatric kidney transplant and clinical parameters associated with physical performance capacity
title_sort physical performance capacity after pediatric kidney transplant and clinical parameters associated with physical performance capacity
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060344/
https://www.ncbi.nlm.nih.gov/pubmed/36315277
http://dx.doi.org/10.1007/s00467-022-05758-0
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