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Minimal Morphoelastic Models of Solid Tumour Spheroids: A Tutorial

Tumour spheroids have been the focus of a variety of mathematical models, ranging from Greenspan’s classical study of the 1970 s through to contemporary agent-based models. Of the many factors that regulate spheroid growth, mechanical effects are perhaps some of the least studied, both theoretically...

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Autores principales: Walker, Benjamin J., Celora, Giulia L., Goriely, Alain, Moulton, Derek E., Byrne, Helen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060352/
https://www.ncbi.nlm.nih.gov/pubmed/36991173
http://dx.doi.org/10.1007/s11538-023-01141-8
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author Walker, Benjamin J.
Celora, Giulia L.
Goriely, Alain
Moulton, Derek E.
Byrne, Helen M.
author_facet Walker, Benjamin J.
Celora, Giulia L.
Goriely, Alain
Moulton, Derek E.
Byrne, Helen M.
author_sort Walker, Benjamin J.
collection PubMed
description Tumour spheroids have been the focus of a variety of mathematical models, ranging from Greenspan’s classical study of the 1970 s through to contemporary agent-based models. Of the many factors that regulate spheroid growth, mechanical effects are perhaps some of the least studied, both theoretically and experimentally, though experimental enquiry has established their significance to tumour growth dynamics. In this tutorial, we formulate a hierarchy of mathematical models of increasing complexity to explore the role of mechanics in spheroid growth, all the while seeking to retain desirable simplicity and analytical tractability. Beginning with the theory of morphoelasticity, which combines solid mechanics and growth, we successively refine our assumptions to develop a somewhat minimal model of mechanically regulated spheroid growth that is free from many unphysical and undesirable behaviours. In doing so, we will see how iterating upon simple models can provide rigorous guarantees of emergent behaviour, which are often precluded by existing, more complex modelling approaches. Perhaps surprisingly, we also demonstrate that the final model considered in this tutorial agrees favourably with classical experimental results, highlighting the potential for simple models to provide mechanistic insight whilst also serving as mathematical examples.
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spelling pubmed-100603522023-03-31 Minimal Morphoelastic Models of Solid Tumour Spheroids: A Tutorial Walker, Benjamin J. Celora, Giulia L. Goriely, Alain Moulton, Derek E. Byrne, Helen M. Bull Math Biol Education Tumour spheroids have been the focus of a variety of mathematical models, ranging from Greenspan’s classical study of the 1970 s through to contemporary agent-based models. Of the many factors that regulate spheroid growth, mechanical effects are perhaps some of the least studied, both theoretically and experimentally, though experimental enquiry has established their significance to tumour growth dynamics. In this tutorial, we formulate a hierarchy of mathematical models of increasing complexity to explore the role of mechanics in spheroid growth, all the while seeking to retain desirable simplicity and analytical tractability. Beginning with the theory of morphoelasticity, which combines solid mechanics and growth, we successively refine our assumptions to develop a somewhat minimal model of mechanically regulated spheroid growth that is free from many unphysical and undesirable behaviours. In doing so, we will see how iterating upon simple models can provide rigorous guarantees of emergent behaviour, which are often precluded by existing, more complex modelling approaches. Perhaps surprisingly, we also demonstrate that the final model considered in this tutorial agrees favourably with classical experimental results, highlighting the potential for simple models to provide mechanistic insight whilst also serving as mathematical examples. Springer US 2023-03-29 2023 /pmc/articles/PMC10060352/ /pubmed/36991173 http://dx.doi.org/10.1007/s11538-023-01141-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Education
Walker, Benjamin J.
Celora, Giulia L.
Goriely, Alain
Moulton, Derek E.
Byrne, Helen M.
Minimal Morphoelastic Models of Solid Tumour Spheroids: A Tutorial
title Minimal Morphoelastic Models of Solid Tumour Spheroids: A Tutorial
title_full Minimal Morphoelastic Models of Solid Tumour Spheroids: A Tutorial
title_fullStr Minimal Morphoelastic Models of Solid Tumour Spheroids: A Tutorial
title_full_unstemmed Minimal Morphoelastic Models of Solid Tumour Spheroids: A Tutorial
title_short Minimal Morphoelastic Models of Solid Tumour Spheroids: A Tutorial
title_sort minimal morphoelastic models of solid tumour spheroids: a tutorial
topic Education
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060352/
https://www.ncbi.nlm.nih.gov/pubmed/36991173
http://dx.doi.org/10.1007/s11538-023-01141-8
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