Discovery of a small molecule ligand of FRS2 that inhibits invasion and tumor growth

PURPOSE: Aberrant activation of the fibroblast growth factor receptor (FGFR) family of receptor tyrosine kinases drives oncogenic signaling through its proximal adaptor protein FRS2. Precise disruption of this disease-causing signal transmission in metastatic cancers could stall tumor growth and pro...

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Detalles Bibliográficos
Autores principales: Santhana Kumar, Karthiga, Brunner, Cyrill, Schuster, Matthias, Kopp, Levi Luca, Gries, Alexandre, Yan, Shen, Jurt, Simon, Moehle, Kerstin, Bruns, Dominique, Grotzer, Michael, Zerbe, Oliver, Schneider, Gisbert, Baumgartner, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060354/
https://www.ncbi.nlm.nih.gov/pubmed/36495366
http://dx.doi.org/10.1007/s13402-022-00753-x

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