VMP1 prevents Ca(2+) overload in endoplasmic reticulum and maintains naive T cell survival

Ca(2+) in endoplasmic reticulum (ER) dictates T cell activation, proliferation, and function via store-operated Ca(2+) entry. How naive T cells maintain an appropriate level of Ca(2+) in ER remains poorly understood. Here, we show that the ER transmembrane protein VMP1 is essential for maintaining E...

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Detalles Bibliográficos
Autores principales: Liu, Ying, Ma, Yuying, Xu, Jing, Zhang, Guangyue, Zhao, Xiaocui, He, Zihao, Wang, Lixia, Yin, Na, Peng, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060355/
https://www.ncbi.nlm.nih.gov/pubmed/36971758
http://dx.doi.org/10.1084/jem.20221068

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