Sex-related differences in the efficacy of Baclofen enantiomers on self-administered alcohol in a binge drinking pattern and dopamine release in the core of the nucleus accumbens

Introduction: Clinical studies on the effectiveness of Baclofen in alcohol use disorder (AUD) yielded mixed results possibly because of differential effects of the enantiomers and sex-related differences. Here we examined the effect of the different Baclofen enantiomers on alcohol intake and on evok...

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Detalles Bibliográficos
Autores principales: Jeanblanc, Jérôme, Sauton, Pierre, Houdant, Charles, Fernandez Rodriguez, Sandra, de Sousa, Sofia Vilelas, Jeanblanc, Virginie, Bodeau, Sandra, Labat, Laurence, Soichot, Marion, Vorspan, Florence, Naassila, Mickael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060511/
https://www.ncbi.nlm.nih.gov/pubmed/37007041
http://dx.doi.org/10.3389/fphar.2023.1146848

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