B cell M-CLL clones retain selection against replacement mutations in their immunoglobulin gene framework regions

INTRODUCTION: Chronic lymphocytic leukemia (CLL) is the most common adult leukemia, accounting for 30–40% of all adult leukemias. The dynamics of B-lymphocyte CLL clones with mutated immunoglobulin heavy chain variable region (IgHV) genes in their tumor (M-CLL) can be studied using mutational lineag...

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Detalles Bibliográficos
Autores principales: Neuman, Hadas, Arrouasse, Jessica, Benjamini, Ohad, Mehr, Ramit, Kedmi, Meirav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060519/
https://www.ncbi.nlm.nih.gov/pubmed/37007112
http://dx.doi.org/10.3389/fonc.2023.1115361

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060519/
https://www.ncbi.nlm.nih.gov/pubmed/37007112
http://dx.doi.org/10.3389/fonc.2023.1115361

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