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B cell M-CLL clones retain selection against replacement mutations in their immunoglobulin gene framework regions
INTRODUCTION: Chronic lymphocytic leukemia (CLL) is the most common adult leukemia, accounting for 30–40% of all adult leukemias. The dynamics of B-lymphocyte CLL clones with mutated immunoglobulin heavy chain variable region (IgHV) genes in their tumor (M-CLL) can be studied using mutational lineag...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060519/ https://www.ncbi.nlm.nih.gov/pubmed/37007112 http://dx.doi.org/10.3389/fonc.2023.1115361 |