Molecular determinants of μ-conotoxin KIIIA interaction with the human voltage-gated sodium channel Na(V)1.7

The voltage-gated sodium (Na(V)) channel subtype Na(V)1.7 plays a critical role in pain signaling, making it an important drug target. Here we studied the molecular interactions between μ-Conotoxin KIIIA (KIIIA) and the human Na(V)1.7 channel (hNa(V)1.7). We developed a structural model of hNa(V)1.7...

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Detalles Bibliográficos
Autores principales: Kimball, Ian H., Nguyen, Phuong T., Olivera, Baldomero M., Sack, Jon T., Yarov-Yarovoy, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060530/
https://www.ncbi.nlm.nih.gov/pubmed/37007002
http://dx.doi.org/10.3389/fphar.2023.1156855

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060530/
https://www.ncbi.nlm.nih.gov/pubmed/37007002
http://dx.doi.org/10.3389/fphar.2023.1156855

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