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Defining the nuanced nature of redox biology in post-traumatic stress disorder

Post-traumatic stress disorder (PTSD) is a mental health disorder that arises after experiencing or witnessing a traumatic event. Despite affecting around 7% of the population, there are currently no definitive biological signatures or biomarkers used in the diagnosis of PTSD. Thus, the search for c...

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Autores principales: Reed, Emily C., Case, Adam J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060537/
https://www.ncbi.nlm.nih.gov/pubmed/37007993
http://dx.doi.org/10.3389/fphys.2023.1130861
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author Reed, Emily C.
Case, Adam J.
author_facet Reed, Emily C.
Case, Adam J.
author_sort Reed, Emily C.
collection PubMed
description Post-traumatic stress disorder (PTSD) is a mental health disorder that arises after experiencing or witnessing a traumatic event. Despite affecting around 7% of the population, there are currently no definitive biological signatures or biomarkers used in the diagnosis of PTSD. Thus, the search for clinically relevant and reproducible biomarkers has been a major focus of the field. With significant advances of large-scale multi-omic studies that include genomic, proteomic, and metabolomic data, promising findings have been made, but the field still has fallen short. Amongst the possible biomarkers examined, one area is often overlooked, understudied, or inappropriately investigated: the field of redox biology. Redox molecules are free radical and/or reactive species that are generated as a consequence of the necessity of electron movement for life. These reactive molecules, too, are essential for life, but in excess are denoted as “oxidative stress” and often associated with many diseases. The few studies that have examined redox biology parameters have often utilized outdated and nonspecific methods, as well as have reported confounding results, which has made it difficult to conclude the role for redox in PTSD. Herein, we provide a foundation of how redox biology may underlie diseases like PTSD, critically examine redox studies of PTSD, and provide future directions the field can implement to enhance standardization, reproducibility, and accuracy of redox assessments for the use of diagnosis, prognosis, and therapy of this debilitating mental health disorder.
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spelling pubmed-100605372023-03-31 Defining the nuanced nature of redox biology in post-traumatic stress disorder Reed, Emily C. Case, Adam J. Front Physiol Physiology Post-traumatic stress disorder (PTSD) is a mental health disorder that arises after experiencing or witnessing a traumatic event. Despite affecting around 7% of the population, there are currently no definitive biological signatures or biomarkers used in the diagnosis of PTSD. Thus, the search for clinically relevant and reproducible biomarkers has been a major focus of the field. With significant advances of large-scale multi-omic studies that include genomic, proteomic, and metabolomic data, promising findings have been made, but the field still has fallen short. Amongst the possible biomarkers examined, one area is often overlooked, understudied, or inappropriately investigated: the field of redox biology. Redox molecules are free radical and/or reactive species that are generated as a consequence of the necessity of electron movement for life. These reactive molecules, too, are essential for life, but in excess are denoted as “oxidative stress” and often associated with many diseases. The few studies that have examined redox biology parameters have often utilized outdated and nonspecific methods, as well as have reported confounding results, which has made it difficult to conclude the role for redox in PTSD. Herein, we provide a foundation of how redox biology may underlie diseases like PTSD, critically examine redox studies of PTSD, and provide future directions the field can implement to enhance standardization, reproducibility, and accuracy of redox assessments for the use of diagnosis, prognosis, and therapy of this debilitating mental health disorder. Frontiers Media S.A. 2023-03-16 /pmc/articles/PMC10060537/ /pubmed/37007993 http://dx.doi.org/10.3389/fphys.2023.1130861 Text en Copyright © 2023 Reed and Case. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Reed, Emily C.
Case, Adam J.
Defining the nuanced nature of redox biology in post-traumatic stress disorder
title Defining the nuanced nature of redox biology in post-traumatic stress disorder
title_full Defining the nuanced nature of redox biology in post-traumatic stress disorder
title_fullStr Defining the nuanced nature of redox biology in post-traumatic stress disorder
title_full_unstemmed Defining the nuanced nature of redox biology in post-traumatic stress disorder
title_short Defining the nuanced nature of redox biology in post-traumatic stress disorder
title_sort defining the nuanced nature of redox biology in post-traumatic stress disorder
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060537/
https://www.ncbi.nlm.nih.gov/pubmed/37007993
http://dx.doi.org/10.3389/fphys.2023.1130861
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