Cargando…

Serum creatinine levels, traditional cardiovascular risk factors and 10-year cardiovascular risk in Chinese patients with hypertension

BACKGROUND: Serum creatinine is associated with cardiovascular risk and cardiovascular events, however, the relationship between serum creatinine levels and cardiovascular risk is not well established in hypertensive population in Jiangsu Province. We aimed to evaluate the association of serum creat...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Xin, Jin, Hang, Wang, Dan, Liu, Jiali, Qin, Yu, Zhang, Yongqing, Zhang, Yuqing, Xiang, Quanyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060819/
https://www.ncbi.nlm.nih.gov/pubmed/37008918
http://dx.doi.org/10.3389/fendo.2023.1140093
_version_ 1785017159031717888
author Chen, Xin
Jin, Hang
Wang, Dan
Liu, Jiali
Qin, Yu
Zhang, Yongqing
Zhang, Yuqing
Xiang, Quanyong
author_facet Chen, Xin
Jin, Hang
Wang, Dan
Liu, Jiali
Qin, Yu
Zhang, Yongqing
Zhang, Yuqing
Xiang, Quanyong
author_sort Chen, Xin
collection PubMed
description BACKGROUND: Serum creatinine is associated with cardiovascular risk and cardiovascular events, however, the relationship between serum creatinine levels and cardiovascular risk is not well established in hypertensive population in Jiangsu Province. We aimed to evaluate the association of serum creatinine levels with traditional cardiovascular risk factors and 10-year cardiovascular risk in a Chinese hypertensive population. METHODS: Participants were patients with hypertension registered and enrolled in health service centers in 5 counties or districts from January 2019 to May 2020 in Jiangsu Province of China followed strict inclusion and exclusion criteria, demographics as well as clinical indicators and disease history and lifestyle were collected. Participants were divided into four groups according to quartiles of serum creatinine levels, then the China-PAR model was used to calculate 10-year cardiovascular risk for each individual. RESULTS: A total of 9978 participants were enrolled in this study, 4173(41.82%) were males. The blood pressure level and prevalence of dyslipidemia, elderly, current smokers and drinking as well as obesity were higher in the Q4 group than the Q1 group (all P < 0.05). Multivariable logistic regression showed that serum creatinine in the Q4 group compared with that in the Q1 group was positively associated with overweight and obesity (OR=1.432, 95% CI 1.237-1.658, P<0.001), while negatively associated with physical activity (OR=0.189, 95%CI 0.165-0.217, P<0.001), and so on. Multiple linear regression showed 10-year cardiovascular risk is positively associated with serum creatinine levels after adjusting for multiple risk factors (β=0.432, P< 0.001). CONCLUSION: Serum creatinine was associated with several traditional cardiovascular risk factors and the 10-year cardiovascular risk in hypertensive patients. Creatinine-reduction and kidney-sparing therapy are essential for patients with hypertension to optimize control of cardiovascular risk.
format Online
Article
Text
id pubmed-10060819
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-100608192023-03-31 Serum creatinine levels, traditional cardiovascular risk factors and 10-year cardiovascular risk in Chinese patients with hypertension Chen, Xin Jin, Hang Wang, Dan Liu, Jiali Qin, Yu Zhang, Yongqing Zhang, Yuqing Xiang, Quanyong Front Endocrinol (Lausanne) Endocrinology BACKGROUND: Serum creatinine is associated with cardiovascular risk and cardiovascular events, however, the relationship between serum creatinine levels and cardiovascular risk is not well established in hypertensive population in Jiangsu Province. We aimed to evaluate the association of serum creatinine levels with traditional cardiovascular risk factors and 10-year cardiovascular risk in a Chinese hypertensive population. METHODS: Participants were patients with hypertension registered and enrolled in health service centers in 5 counties or districts from January 2019 to May 2020 in Jiangsu Province of China followed strict inclusion and exclusion criteria, demographics as well as clinical indicators and disease history and lifestyle were collected. Participants were divided into four groups according to quartiles of serum creatinine levels, then the China-PAR model was used to calculate 10-year cardiovascular risk for each individual. RESULTS: A total of 9978 participants were enrolled in this study, 4173(41.82%) were males. The blood pressure level and prevalence of dyslipidemia, elderly, current smokers and drinking as well as obesity were higher in the Q4 group than the Q1 group (all P < 0.05). Multivariable logistic regression showed that serum creatinine in the Q4 group compared with that in the Q1 group was positively associated with overweight and obesity (OR=1.432, 95% CI 1.237-1.658, P<0.001), while negatively associated with physical activity (OR=0.189, 95%CI 0.165-0.217, P<0.001), and so on. Multiple linear regression showed 10-year cardiovascular risk is positively associated with serum creatinine levels after adjusting for multiple risk factors (β=0.432, P< 0.001). CONCLUSION: Serum creatinine was associated with several traditional cardiovascular risk factors and the 10-year cardiovascular risk in hypertensive patients. Creatinine-reduction and kidney-sparing therapy are essential for patients with hypertension to optimize control of cardiovascular risk. Frontiers Media S.A. 2023-03-16 /pmc/articles/PMC10060819/ /pubmed/37008918 http://dx.doi.org/10.3389/fendo.2023.1140093 Text en Copyright © 2023 Chen, Jin, Wang, Liu, Qin, Zhang, Zhang and Xiang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Chen, Xin
Jin, Hang
Wang, Dan
Liu, Jiali
Qin, Yu
Zhang, Yongqing
Zhang, Yuqing
Xiang, Quanyong
Serum creatinine levels, traditional cardiovascular risk factors and 10-year cardiovascular risk in Chinese patients with hypertension
title Serum creatinine levels, traditional cardiovascular risk factors and 10-year cardiovascular risk in Chinese patients with hypertension
title_full Serum creatinine levels, traditional cardiovascular risk factors and 10-year cardiovascular risk in Chinese patients with hypertension
title_fullStr Serum creatinine levels, traditional cardiovascular risk factors and 10-year cardiovascular risk in Chinese patients with hypertension
title_full_unstemmed Serum creatinine levels, traditional cardiovascular risk factors and 10-year cardiovascular risk in Chinese patients with hypertension
title_short Serum creatinine levels, traditional cardiovascular risk factors and 10-year cardiovascular risk in Chinese patients with hypertension
title_sort serum creatinine levels, traditional cardiovascular risk factors and 10-year cardiovascular risk in chinese patients with hypertension
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060819/
https://www.ncbi.nlm.nih.gov/pubmed/37008918
http://dx.doi.org/10.3389/fendo.2023.1140093
work_keys_str_mv AT chenxin serumcreatininelevelstraditionalcardiovascularriskfactorsand10yearcardiovascularriskinchinesepatientswithhypertension
AT jinhang serumcreatininelevelstraditionalcardiovascularriskfactorsand10yearcardiovascularriskinchinesepatientswithhypertension
AT wangdan serumcreatininelevelstraditionalcardiovascularriskfactorsand10yearcardiovascularriskinchinesepatientswithhypertension
AT liujiali serumcreatininelevelstraditionalcardiovascularriskfactorsand10yearcardiovascularriskinchinesepatientswithhypertension
AT qinyu serumcreatininelevelstraditionalcardiovascularriskfactorsand10yearcardiovascularriskinchinesepatientswithhypertension
AT zhangyongqing serumcreatininelevelstraditionalcardiovascularriskfactorsand10yearcardiovascularriskinchinesepatientswithhypertension
AT zhangyuqing serumcreatininelevelstraditionalcardiovascularriskfactorsand10yearcardiovascularriskinchinesepatientswithhypertension
AT xiangquanyong serumcreatininelevelstraditionalcardiovascularriskfactorsand10yearcardiovascularriskinchinesepatientswithhypertension