The impact of hepatocyte-specific deletion of hypoxia-inducible factors on the development of polymicrobial sepsis with focus on GR and PPARα function

INTRODUCTION: Polymicrobial sepsis causes acute anorexia (loss of appetite), leading to lipolysis in white adipose tissue and proteolysis in muscle, and thus release of free fatty acids (FFAs), glycerol and gluconeogenic amino acids. Since hepatic peroxisome proliferator-activated receptor alpha (PP...

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Detalles Bibliográficos
Autores principales: Vanderhaeghen, Tineke, Timmermans, Steven, Eggermont, Melanie, Watts, Deepika, Vandewalle, Jolien, Wallaeys, Charlotte, Nuyttens, Louise, De Temmerman, Joyca, Hochepied, Tino, Dewaele, Sylviane, Berghe, Joke Vanden, Sanders, Niek, Wielockx, Ben, Beyaert, Rudi, Libert, Claude
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060827/
https://www.ncbi.nlm.nih.gov/pubmed/37006237
http://dx.doi.org/10.3389/fimmu.2023.1124011

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