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Emerging mechanistic insights of selective autophagy in hepatic diseases

Macroautophagy (hereafter referred to as autophagy), a highly conserved metabolic process, regulates cellular homeostasis by degrading dysfunctional cytosolic constituents and invading pathogens via the lysosomal system. In addition, autophagy selectively recycles specific organelles such as damaged...

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Autores principales: Alim Al-Bari, Abdul, Ito, Yuko, Thomes, Paul G., Menon, Manoj B., García-Macia, Marina, Fadel, Raouf, Stadlin, Alfreda, Peake, Nicholas, Faris, MoezAlIslam Ezzat, Eid, Nabil, Klionsky, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060854/
https://www.ncbi.nlm.nih.gov/pubmed/37007026
http://dx.doi.org/10.3389/fphar.2023.1149809
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author Alim Al-Bari, Abdul
Ito, Yuko
Thomes, Paul G.
Menon, Manoj B.
García-Macia, Marina
Fadel, Raouf
Stadlin, Alfreda
Peake, Nicholas
Faris, MoezAlIslam Ezzat
Eid, Nabil
Klionsky, Daniel J.
author_facet Alim Al-Bari, Abdul
Ito, Yuko
Thomes, Paul G.
Menon, Manoj B.
García-Macia, Marina
Fadel, Raouf
Stadlin, Alfreda
Peake, Nicholas
Faris, MoezAlIslam Ezzat
Eid, Nabil
Klionsky, Daniel J.
author_sort Alim Al-Bari, Abdul
collection PubMed
description Macroautophagy (hereafter referred to as autophagy), a highly conserved metabolic process, regulates cellular homeostasis by degrading dysfunctional cytosolic constituents and invading pathogens via the lysosomal system. In addition, autophagy selectively recycles specific organelles such as damaged mitochondria (via mitophagy), and lipid droplets (LDs; via lipophagy) or eliminates specialized intracellular pathogenic microorganisms such as hepatitis B virus (HBV) and coronaviruses (via virophagy). Selective autophagy, particularly mitophagy, plays a key role in the preservation of healthy liver physiology, and its dysfunction is connected to the pathogenesis of a wide variety of liver diseases. For example, lipophagy has emerged as a defensive mechanism against chronic liver diseases. There is a prominent role for mitophagy and lipophagy in hepatic pathologies including non-alcoholic fatty liver disease (NAFLD), hepatocellular carcinoma (HCC), and drug-induced liver injury. Moreover, these selective autophagy pathways including virophagy are being investigated in the context of viral hepatitis and, more recently, the coronavirus disease 2019 (COVID-19)-associated hepatic pathologies. The interplay between diverse types of selective autophagy and its impact on liver diseases is briefly addressed. Thus, modulating selective autophagy (e.g., mitophagy) would seem to be effective in improving liver diseases. Considering the prominence of selective autophagy in liver physiology, this review summarizes the current understanding of the molecular mechanisms and functions of selective autophagy (mainly mitophagy and lipophagy) in liver physiology and pathophysiology. This may help in finding therapeutic interventions targeting hepatic diseases via manipulation of selective autophagy.
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spelling pubmed-100608542023-03-31 Emerging mechanistic insights of selective autophagy in hepatic diseases Alim Al-Bari, Abdul Ito, Yuko Thomes, Paul G. Menon, Manoj B. García-Macia, Marina Fadel, Raouf Stadlin, Alfreda Peake, Nicholas Faris, MoezAlIslam Ezzat Eid, Nabil Klionsky, Daniel J. Front Pharmacol Pharmacology Macroautophagy (hereafter referred to as autophagy), a highly conserved metabolic process, regulates cellular homeostasis by degrading dysfunctional cytosolic constituents and invading pathogens via the lysosomal system. In addition, autophagy selectively recycles specific organelles such as damaged mitochondria (via mitophagy), and lipid droplets (LDs; via lipophagy) or eliminates specialized intracellular pathogenic microorganisms such as hepatitis B virus (HBV) and coronaviruses (via virophagy). Selective autophagy, particularly mitophagy, plays a key role in the preservation of healthy liver physiology, and its dysfunction is connected to the pathogenesis of a wide variety of liver diseases. For example, lipophagy has emerged as a defensive mechanism against chronic liver diseases. There is a prominent role for mitophagy and lipophagy in hepatic pathologies including non-alcoholic fatty liver disease (NAFLD), hepatocellular carcinoma (HCC), and drug-induced liver injury. Moreover, these selective autophagy pathways including virophagy are being investigated in the context of viral hepatitis and, more recently, the coronavirus disease 2019 (COVID-19)-associated hepatic pathologies. The interplay between diverse types of selective autophagy and its impact on liver diseases is briefly addressed. Thus, modulating selective autophagy (e.g., mitophagy) would seem to be effective in improving liver diseases. Considering the prominence of selective autophagy in liver physiology, this review summarizes the current understanding of the molecular mechanisms and functions of selective autophagy (mainly mitophagy and lipophagy) in liver physiology and pathophysiology. This may help in finding therapeutic interventions targeting hepatic diseases via manipulation of selective autophagy. Frontiers Media S.A. 2023-03-16 /pmc/articles/PMC10060854/ /pubmed/37007026 http://dx.doi.org/10.3389/fphar.2023.1149809 Text en Copyright © 2023 Alim Al-Bari, Ito, Thomes, Menon, García-Macia, Fadel, Stadlin, Peake, Faris, Eid and Klionsky. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Alim Al-Bari, Abdul
Ito, Yuko
Thomes, Paul G.
Menon, Manoj B.
García-Macia, Marina
Fadel, Raouf
Stadlin, Alfreda
Peake, Nicholas
Faris, MoezAlIslam Ezzat
Eid, Nabil
Klionsky, Daniel J.
Emerging mechanistic insights of selective autophagy in hepatic diseases
title Emerging mechanistic insights of selective autophagy in hepatic diseases
title_full Emerging mechanistic insights of selective autophagy in hepatic diseases
title_fullStr Emerging mechanistic insights of selective autophagy in hepatic diseases
title_full_unstemmed Emerging mechanistic insights of selective autophagy in hepatic diseases
title_short Emerging mechanistic insights of selective autophagy in hepatic diseases
title_sort emerging mechanistic insights of selective autophagy in hepatic diseases
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060854/
https://www.ncbi.nlm.nih.gov/pubmed/37007026
http://dx.doi.org/10.3389/fphar.2023.1149809
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