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Methylation of BDNF gene in association with episodic memory in women

Brain-derived neurotrophic factor (BDNF) gene regulation plays an important role in long-term memory formation, and the DNA methylation (DNAm) level of BDNF promoters has been associated with episodic memory deficits. Our aim was to explore the association between DNAm levels in BDNF promoter IV wit...

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Detalles Bibliográficos
Autores principales: Alece Arantes Moreno, Ivana, Rodrigues de Oliveira, Daniela, Ribeiro Borçoi, Aline, Fungaro Rissatti, Luciana, Vitorino Freitas, Flávia, Arantes, Lidia Maria Rebolho Batista, Oliveira Mendes, Suzanny, dos Santos Vieira, Tamires, Risse Quaioto, Bárbara, Cerbino Doblas, Paola, Sgrancio Olinda, Amanda, Ribeiro Cunha, Ester, Gasparini dos Santos, Joaquim, Assis Pinheiro, Júlia, Pereira Sorroche, Bruna, Madeira Alvares da Silva, Adriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060857/
https://www.ncbi.nlm.nih.gov/pubmed/37008217
http://dx.doi.org/10.3389/fnins.2023.1092406
Descripción
Sumario:Brain-derived neurotrophic factor (BDNF) gene regulation plays an important role in long-term memory formation, and the DNA methylation (DNAm) level of BDNF promoters has been associated with episodic memory deficits. Our aim was to explore the association between DNAm levels in BDNF promoter IV with verbal learning and memory performance in healthy women. We conducted a cross-sectional study by recruiting 53 individuals. Episodic memory was assessed by using the Rey Auditory Verbal Learning Test (RAVLT). Clinical interviews, RAVLT, and blood sample collection were assessed in all participants. DNAm was measured on DNA from whole peripheral blood using pyrosequencing. According to generalized linear model (GzLM) analyses, cytosine guanine dinucleotide (CpG) site 5 showed significant associations between learning capacity (LC, p < 0.035), that is, every 1% of DNA methylation at CpG site 5 results in a 0.068 reduction in verbal learning performance. To the best of our knowledge, the current study is the first to show that BDNF DNAm plays an important role in episodic memory.